Other highlights in the November 17 JNCI
...he development of EpsteinBarr virus (EBV)-positive lymphomas in patients with autoimmune diseases by reactivati...g mononucleosis and Hodgkin lymphoma. EBV-positive lymphomas occur more frequently in rheumatoid arthritis and polymyositis patients taking the drug methotrexate...TEL2 gene cooperates with MYC gene to provoke B-cell lymphomas
...phoma. It was already known that many human B-cell lymphomas over-express the MYC gene, either because the tumo...ion," Grosveld said. "In fact, all TEL2/MYC B-cell lymphomas had lost their p53 function." Grosveld's team found that this sequence of events modeled in the mou...Columbia University researchers create mouse model that develops a human-like lymphoma
...ommon type of human B cell lymphoma. Human B cell lymphomas cause 85 percent of non-Hodgkin's lymphomas, the sixth leading cause of cancer deaths in the United States. The findings also confirm that a mutation in BCL6, the gene most frequently altered in this type of lymphoma, is the first step in its develop...Other highlights in the June 1 JNCI
...isk of developing childhood lymphoid leukemias and lymphomas in addition to epithelial tumors later in life. Studies have also indicated that individuals who carry one mutated copy of the ATM gene (i.e., heterozygous mutation carriers) may have a higher risk of breast cancer and perhaps other cancers, but the ...Study establishes new class of cancer-causing genes
...-92 microRNAs in human tumor biopsies including 46 lymphomas and 47 colorectal carcinomas. They observed signif...-17-92 microRNA overexpression of 10-fold in those lymphomas (and a high of 82-fold microRNA overexpression). In contrast, 15% of the colorectal carcinomas displ......wed that a specific cluster of microRNAs can cause lymphomas in mice. Hannon and Lowe, who were recently appoin...ormal human cells and tissues to those with B-cell lymphomas in their expression of the genes for a cluster of miRNAs called mir-17-92. Studies by other research...David M. Goldenberg receives Society of Nuclear Medicine's 2005 Paul C. Aebersold Award
...e of new humanized antibodies for the treatment of lymphomas and autoimmune diseases. He has edited two books on radiolabeled antibodies and 10 journal supplements to Cancer, Cancer Research and Clinical Cancer Research of the proceedings of international conferences he has organized on cancer immunoconjugates...Reversal of role for a viral protein associated with the development of lymphoma
...that the vFLIP-expressing transgenic mice had more lymphomas than the control group mice; 11.8 percent compared...s disease since most patients with HHV8-associated lymphomas are highly immune suppressed and are difficult to treat given the toxicity associated with conventio...VCU Massey Cancer Center researchers find new agent inhibits Leukemia cell survival
...ew treatments for blood cancers such as leukemias, lymphomas and multiple myeloma. His work is funded by the National Cancer Institute, the V Foundation for Cancer Research, the Leukemia and Lymphoma Society of America and the Department of Defense. The first author on the published paper with Grant was Mohame...ECCO 13 evidence suggests link between Chlamydia and OAL
...therapy or radiation." OAL belongs to a group of lymphomas known as mucosa-associated lymphoid tissue (MALT) ...ular changes that lead to the development of these lymphomas result from aberrant immune responses. Infectious agents such as C. psittaci can hence function as c...Researchers use 'trickery' to create immune response against melanoma
...d this makes most cancers, including melanomas and lymphomas of the skin, extremely challenging to treat with existing immunotherapies," said Louis D. Falo, M.D., Ph.D., professor and chairman of the department of dermatology at the University of Pittsburgh School of Medicine. "While we know that dendritic cel...PCBs, furans may factor in risk of non-Hodgkin lymphoma
...th the average survival of patients with low-grade lymphomas about six to eight years after diagnosis. Some 30 percent of patients diagnosed with high-grade lymphomas are permanently cured after treatment, which varies by type of lymphoma and response to chemotherapi...AutovaxID-C introduced by Accentia Biopharmaceuticals
...idiotype vaccine to treat follicular non-Hodgkin's lymphomas in a Phase 3 clinical trial." "Our approach is unique in that it uses hybridoma technology to produce complete idiotype proteins identical to those on the tumor B cells. Results from early clinical trials are very encouraging and generating a lot of ...AutovaxID-C introduced by Biovest International
...idiotype vaccine to treat follicular non-Hodgkin's lymphomas in a Phase 3 clinical trial." "Our approach is unique in that it uses hybridoma technology to produce complete idiotype proteins identical to those on the tumor B cells. Results from early clinical trials are very encouraging and generating a lot of ...Other highlights in the January 4 JNCI
...rified (true positive) cases of cancer, especially lymphomas and leukemias, in family members more often than those in the control group, but cancer patients also reported unverified (false positive) cases of family cancer slightly more often than control subjects. The authors write that self-reported data on...JCI table of contents: January 4, 2006
... dysregulated in mucosa-associated lymphoid tissue lymphomas AUTHOR CONTACT: Xiaolu Yang University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA Phone: 215-573-6739; Fax: 215-573-6725 E-mail: xyang@mail.med.upenn.edu . View the PDF of this article at: https://www.the-jci.org/articl...Better model of deadly brain cancer
...he mice live into early adulthood, but then die of lymphomas caused by translocations of antibody genes. The researchers noted that by this time, the mice were also beginning to develop medulloblastomas. After they made that observation, Alt's team wanted to zero in on the possible role of XRCC4 deficiency in...Diagnostic breakthrough for Burkitt lymphoma reported in NEJM
...ell lymphoma that accounts for 30 to 50 percent of lymphomas in children but only 1 to 2 percent of lymphomas in adults. Burkitt lymphoma is rapidly fatal if untreated, but it is curable with intensive therapy....Clue found to Epstein-Barr virus' ability to form and sustain tumors
...s of human cancers, including Hodgkin's lymphomas, lymphomas in AIDS patients and organ transplant recipients as well as nasopharyngeal carcinomas. The SMPH researchers, based at the McArdle Laboratory for Cancer Research, focused on a viral protein they had previously found to be necessary to keeping Burkitt......rs of cancer using RNAi A subset of non-Hodgkin lymphomas are known as anaplastic large cell lymphomas (ALCLs). Many of these lymphomas are characterized by inappropriate constant activation of a protein...