Attacks of King George III's madness linked to key metabolism molecule
...I suffered from five prolonged, severe episodes of madness during his rule from 1760 to 1820, a period in which he both expanded the British Empire and so stubbornly refused to negotiate with the rebellious American Colonists that they felt only a revolution against England could resolve their grievances. Th...Researchers reveal basis for debilitating hereditary disease
...ease. In July, British researchers connected the madness of King George III to one of the porphyrias. "The atomic image of the enzyme teaches us the inner workings of this molecular machine. Particularly, it helps us understand how mutations cause the enzyme to fail, disrupt the heme biosynthesis pathway...