Researchers identify target for cancer drugs
...utated and unable to function, Akt breaks free. It makes its way to the cell membrane where other proteins activate it, thereby enabling Akt to contribute to tumor growth. "When a cell loses PTEN through, say, a mutation, Akt goes gangbusters," says Sabatini. The exact means by which Akt switches on when i...'I had them a moment ago, now where are my glasses?'
... and the decision phase of the behavior. The model makes several predictions about the neurological basis of working memory that can be tested to confirm the likelihood that the model is a significant advance toward understanding fundamental properties of brain structure and function....Brain region learns to anticipate risk, provides early warnings. suggests new study in Science
...ng to be consciously aware of it," Brown said. "It makes sense that this mechanism exists because there are...new discoveries. "In fact, our computer model also makes some other exciting predictions about how the ACC works, but we haven't had an opportunity to test t...Purdue proves concept of using nano-materials for drug discovery
...ontains numerous pores. This "nanoporous" material makes it possible to carry out reactions inside the vessels. The goal is to produce "laboratories-on-a-chip" less than a half-inch square that might contain up to a million test chambers, or "reactors," each capable of screening an individual drug, said Gi...Molecular machine may lead to new drugs to combat human diseases
..., an infection of tissues in the oral cavity. This makes introns a potential target for therapeutics against these diseases by using a strategy called targeted trans-splicing in which introns are manipulated to cut out malfunctioning genes. Introns' unique capability of cutting and pasting apparently has ...Technological revolutions in sensors, robotics, and telecommunications allow new views of ocean
...ompetitive edge of these experienced fishermen and makes it easier for a population to be overfished, but i...can watch recently tagged fish for several days to makes sure they return to normal behavior it's vital to our research." Once the animals are tagged and ac...Coastal dead zones may lead to ecosystem-based fisheries management
..." he said. "But when you pull them all together it makes for a pretty interesting case." His previous publi...spire to trap the fish on the bottom in a way that makes it hard for them to escape the low-oxygen waters, he added. In the Gulf, "to date no one has been ab...Muon opportunists: Detecting the unseen with natural probes
...ounts of rock or metal with ease, yet their charge makes them easy to track. Researchers described several promising uses for muon radiography, as it is called, at the annual meeting of the American Association for the Advancement of Science (AAAS). Arturo Menchaca-Rocha, director of the physics institut...The world's smallest synchrotron, MIRRORCLE-6X, now commercially available
...timately constrains aspirations on its usage. What makes MIRRORCLE-6X so intriguing is that for the first time it may be possible to proliferate synchrotron light with a very low entrance fee. This is the dream of Professor Hironari Yamada, researcher and inventor at Ritsumeikan University in Kusatsu, Japa...Why some lung cancers stop responding to Tarceva and Iressa
... we found is strictly analogous to a mutation that makes other kinds of tumors resistant to another targete...ling enzymes like EGFR. Non-small cell lung cancer makes up about 80 percent of all lung cancers. Mutations in a gene called KRAS (pronounced KAY-rass),which...'Blinding' an insect's sense of smell may be the best repellent
... but from the point of view of vulnerability, this makes them very vulnerable to strategies that would block their sense of smell. If we could use this to chemically interrupt the transport of the odorant receptors, we could make mosquitoes 'blind' to humans. That in turn would be a good way to prevent d...Antibody that neutralizes most HIV strains described by scientists at The Scripps Research Institute
... However, this is easier said than done. The body makes many antibodies against HIV, but they are almost always unable to neutralize the virus. Nonetheless, the immune systems of some patients with HIV have beaten the odds and have produced effective neutralizing antibodies. The structure of one of these,...Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer
...me data will help researchers find more about what makes some people innately resistant to infection by E. histolytica, and what acquired immune responses can protect people from re-infection. Says Petri: "The genome project has spawned rapid discovery of the parasite's mechanisms for replication, gene exp...Neuronal 'traffic jam' marks early Alzheimer's disease
...berrant form of amyloid beta (A-beta) peptide that makes up the plaques that surround the neurons of people...tion and plaque deposition," said Goldstein. "This makes it clear there is some mechanistic connection between the transport deficit and plaque deposition. "...Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
... need to understand that prenatal undernourishment makes a person permanently at higher risk for developing diabetes, so prenatal care is important," Dr. Patti said. "Moreover, if someone was born with low weight, they need to pay special attention to prevention tactics, including exercise and weight contr...New binding target for oncogenic viral protein
...Fbw7 is itself an important tumor suppressor which makes it an attractive choice for inactivation by Large T," explained Dr. Markus Welcker, the study's first author. The research appears as the "Paper of the Week" in the March 4 issue of the Journal of Biological Chemistry , an American Society for Bioch...New dinosaur raptor found; First in Southern Hemisphere
...hat are now Asia and North America. And thats what makes Neuquenraptor so special. According to current geologic theory, the Earth of 90 million years ago featured two giant supercontinents -- one called Laurasia that eventually split into Europe, Asia, and North America, and another called Gondwana that b...Three bacterial genomes found lurking inside recently sequenced fruit fly genomes
... a vocal advocate of open access publishing, which makes the results of all research and research data freely available on the Internet. "The discovery of these three new genomes demonstrates how powerful the public release of raw sequencing data can be," wrote the authors, who have deposited their finding...Virginia Tech patents advance microprocessors, vaccines, vision, vibration control, more
...inexpensive." Lee's invention is unique because it makes it possible to dim a florescent light. "It uses oscillation technology so that the ballast does not have to be turned on and off using an external drive circuit and, thus, is cost effective." The research sponsor was Matsushita Electric Works, the la...Asian interest provides opportunities for US hard white wheat
... of availability of hard white,Rudd said. Korea makes a wide variety of noodles and steamed bread. For this, hardwhite varieties with typical hard red winter wheat quality will work ifthe ash is low, he said, and it has a greater elasticity of the dough. "Strong gluten we have, but the elasticity is ...