Army-funded effort examines androgen's role in bone loss
...sthma, alcoholism, chronic smoking and bone marrow malignancies are believed to cause androgen deficiency. All in addition to reduced hormone secretion from the testes, a condition called hypogonadism are associated with osteoporosis development in men. The disease also is a side effect of androgen depriv...Growth of common skin cancer blocked in gene-switch mice
...ncogene is frequently followed by the emergence of malignancies that have activated alternative cancer-causing pathways. The fact that this does not happen in regressed mouse BCCs suggests that any residual human BCC cells, if present, should also remain in check as long as the Hh pathway is effectively inhibite...COX-2 levels are elevated in smokers
...pproaches for reducing the risk of tobacco-related malignancies of the mouth and throat," Dannenberg said. Dannenberg investigated the mechanism of tobacco smoke effects on oral mucosa with team of scientists including Dimitrios Moraitis, M.D., Jay O. Boyle, M.D., and Erik G. Cohen, M.D., Memorial Sloan-Kettering...Anti cancer virotherapy well tolerated in first human administration, research finds
...as potential therapies for different hard to treat malignancies including melanoma and ovarian cancer. These viruses occur naturally and routinely in the community causing mild infections in adult humans. Previously the Shafren group has published research on CVA21 that showed success in specifically targeting an...Novel ultrafast laser detection of cancer cells also may improve understanding of stem cells
...r cells from solid tumors as well as hematological malignancies like leukemia." Naviaux looks forward to examining a wider population of cancer cells to validate the method, combining the resources of his Center with Sandia's laser expertise. A project proposal has been filed with Sandia to support collaborative...New tumor suppressor gene linked to cancer predisposition
...wn as a rich source of mutations linked to various malignancies might be the location of other genes important in carcinogenesis. Multiple tests with a portion of that DNA yielded ARLTS1 as a specific new gene. ARLTS1 belongs to the Ras superfamily of genes that regulates cell growth. Most of the genes in that ...Patients undergoing PET/CT may want to pass on that cup of coffee, according to SNMTS study
...procedure to evaluate potential known or suspected malignancies should forgo coffee before the test, according to the results of study released at the Society of Nuclear Medicine's 52nd Annual Meeting June 1822 in Toronto. "It is advisable for patients to stop caffeine intake for a 24-hour period prior to imaging...High-powered gene profiles provide clues to genes involved in common form of lung cancer
...pe of lung cancer and one of the deadliest of all malignancies and a range of possible targets for future therapies. The study will be reported in the Proceedings of the National Academy of Sciences' Online Early Edition ( www.pnas.org/papbyrecent.shtml ) the week of June 27. "Previous studies have identified...Interim data suggest major response with Aranesp(R) in anemic patients with MDS
...include all adult cancer patients with non-myeloid malignancies receiving chemotherapy. In 2004, Aranesp was approved by the EMEA for every-three-week dosing in patients with chemotherapy-induced anemia and up to once-per-month dosing in the treatment of anemia in chronic kidney disease patients not on dialysis. ...Other highlights in the August 3 JNCI
...on was associated with risk of lymphohematopoietic malignancies (cancers of the blood and lymph systems), Graham G... participant. They also gathered information about malignancies from the population cancer registry. The authors found that risk of myeloid leukemia was positively ...JCI table of contents September 1, 2005
...em. A common anomaly associated with these myeloid malignancies is a chromosomal deletion, suggesting the presence of one or more tumor suppressor genes in the long arm of chromosome 20. In a paper appearing online on August 25 in advance of print publication of the September 1 issue of the Journal of Clinical I...Found! First gene associated with myeloproliferative diseases
...em. A common anomaly associated with these myeloid malignancies is a chromosomal deletion, suggesting the presence of one or more tumor suppressor genes in the long arm of chromosome 20. In a paper appearing online on August 25 in advance of print publication of the September 1 issue of the Journal of Clinical I...Other highlights in the September 21 JNCI
...ple cases of these two types of melanoma and other malignancies to identify melanoma susceptibility genes. Linkage to chromosome 9q21.32 was observed in three of the families studied. The authors also examined tumor tissue from 10 sporadic cutaneous malignant melanoma lesions for expression of RASEF, a known gen...JCI table of contents November, 2005
... pathways contributing to the development of human malignancies and, perhaps working in parallel with well-documented p53- and Rb-driven oncogenic pathways in human tumors. Using E1A, an early gene product of tumorigenic adenovirus, which transforms cells in culture and forces terminally differentiated cells to...Mice provide insight into therapy-induced cancers in humans
...cers. "These animals develop a similar spectrum of malignancies as human patients who are treated with radiation and alkylating agents, and provide a tractable system for performing mechanistic studies, for comparing the mutagenic potential of different regimens, and for testing preventive strategies," offers Dr....Expression Project for Oncology (expO) collects 1,000th malignant tumor specimen
...0 tumor specimens representing a broad spectrum of malignancies and 500-1,000 normal tissues. The project is well on its way to meeting this goal. So far, IGC has collected a total of 5,083 biospecimens including frozen biosamples and paraffin tissue blocks containing normal, paranormal and malignant tissue and p...U-M scientists say fused genes trigger the development of prostate cancer
...w gene rearrangements were involved in hematologic malignancies and sarcomas. But finding this recurrent chromosomal rearrangement in prostate cancer suggests that other common epithelial cancers have their own recurrent chromosomal rearrangements. We just haven't found them yet." A bioinformatics analysis method...New ECCO 13 studies probe impact of haematological cancer therapy on future fertility
...f chemotherapy and radiotherapy for haematological malignancies on subsequent patient fertility. The first such study looked at 276 males and 221 females treated for Hodgkin's lymphoma at the Norwegian Radium Hospital between 1971 and 1999. An average of 16 years after their cancer therapy these patients were que...UF, Columbia scientists closer to new cancer detection method
...ms of cancer, and have been found in patients with malignancies of the ovaries, kidneys, lung, pancreas and brain. After the probe physically conforms to the PDGF, the molecule can be snapped on like a light switch to flash a fluorescent signal. Tan, the associate director of UF's Center for Research at the Bio/N......f the United States population, but second primary malignancies among this group account for 16% of all cancer incidence. In a commentary, Lois B. Travis, M.D., of the National Cancer Institute (NCI) in Bethesda, and colleagues highlight research priorities identified at a 2004 NCI workshop called "Cancer Survivo...