New databases put wings on search for bipolar risk genes
...only marked by alternating bouts of depression and manic or overexcited behavior. Because DNA samples also are available for this group, the database will let researchers correlate specific symptoms with sequences of genetic material. The new database, available at http://www.hopkinsmedicine.org/Psychi...$9M grant awarded to University of Cincinnati for bipolar disorder research
...iods of normal mood in between. Some symptoms of a manic episode include increased energy, activity and restlessness, excessively high or overly euphoric mood, and extreme irritability. In contrast, a depressive episode is characterized by a lasting sad, anxious, or empty mood, feelings of hopelessness or ...Study of damaged gene gives insight into causes of mental illness
...tified this gene as being linked to schizophrenia, manic depression (bipolar affective disorder) and major depression. The gene was also found to be essential for brain signalling and plays a key role in learning, memory and mood. To further their findings, experts looked at the behaviour of mice with tw...Delayed treatment of childhood-onset bipolar disorder results in negative outcome in adults
... other institutions determined the age of onset of manic or depressive symptoms and the age of first treatm... period (ultradian cycling), and greater number of manic and depressive episodes throughout their lives. The patients also had an increased risk of substanc...Gene controlling circadian rhythms may be involved in onset of bipolar disorder
...olar disorder, especially when patients are in the manic state." During the study, lithium was given to the mutant mice. Lithium, a mood-stabilizing medication, is most commonly used in humans to treat bipolar patients. Once treated with the drug on a regular basis, the majority of the study's mice rever...Extreme irritability -- is it childhood bipolar disorder?
...over-excited, elated moods and irritability -- the manic phase of the disorder -- to depression. In contra...ritable and hyperactive, but do not have clear-cut manic episodes. One component of irritability is the tendency to get acutely frustrated when a goal is ...Feinstein Institute and Cold Spring Harbor Lab join forces, seek manic depression genes
...titute in Manhasset, NY. Commonly referred to as manic depression, BPD is a mood disorder that goes beyond the day's ordinary ups and downs, becoming a serious medical condition and an important health concern in the United States. More than 2.3 million American adults are diagnosed with bipolar disorder...Researchers lift a corner of the veil of depression
...n is involved in the development of depression and manic depression. Depression and manic depression Depression is one of the most prevalent disorders in the Western world, and, according t...Link suggested between regions on two chromosomes and bipolar disorder
...nce so far linking bipolar disorder, also known as manic depression, to two chromosomal regions in the human genome. The finding gives scientists refined targets for further gene studies. "Even though bipolar disorder affects millions of people around the world--sometimes throughout their lifetimes--what w...New bipolar survey: Patients' satisfaction influenced
... disorder I need a treatment which can control the manic symptoms but also treat the more disabling depressive symptoms," comments Michael Grinter, SEROQUEL patient and Thinking Ahead Taskforce member. "The treatment that I am currently taking, SEROQUEL, has brought an enormous benefit to my life in terms ......nd take them preventively, as soon as they sense a manic episode coming on." Clinical trials of a PKC inhibitor, the anti-cancer drug tamoxifen, are currently underway in bipolar disorder patients. However, these may be more important for proof-of-concept than therapeutic utility, according to Manji, who s...