UCI researchers discover key factor for survival of human embryonic stem cells
...herapy, and has limited our ability to genetically manipulate the cells, which we must do before they can be transplanted into patients. It appears that if we treat hES cells with neurotrophins, we can produce more of them faster and, hopefully, at much lower cost." Understanding the role that neurotrophins pl...Gene design program from Johns Hopkins simplifies, automates and speeds design of 'artificial' genes
...eries to automate the tasks required to design and manipulate synthetic DNA sequences. The program allows the user to start with either the sequence of the amino acid making up the protein or the bases making up the gene that codes for that protein. Then the user moves through a series of steps that guide the d...Wisconsin scientists find a way to make human collagen in the lab
... -- because it gives scientists a way to precisely manipulate the lengthy molecules and add elements to collagen...d these molecules up one atom at a time and we can manipulate them in very precise ways." The new Wisconsin study, which was supported by grants from the National...New brain hormone puts brakes on reproduction
...and also provide animal breeders with a new way to manipulate the productivity of livestock. The findings by Kriegsfeld and colleagues are reported this week in the online early edition of Proceedings of the National Academy of Sciences. The human reproductive system is regulated like a thermostat, with a numbe...DNA end caps may lead to cancer treatments, UT Southwestern researchers report
...portant for our ultimate ability to understand and manipulate these things for a variety of purposes," Dr. Wrigh...ze is regulated, since we would like to be able to manipulate it for therapeutic purposes," he said. Dr. Wright and his collaborator, Dr. Jerry Shay, professor of...Global effort needed to anticipate and prevent potential misuse of advances in life sciences
...cal advances have made it possible to identify and manipulate features of living organisms in useful ways -- leading to improvements in public health, agriculture, and other areas. The globalization of scientific and technical expertise also means that many scientists and other individuals around the world are...Argonne researchers contribute 1000th structure
...aped body of TraR. This information may be used to manipulate this communication to aid helpful bacteria or thwart harmful bacteria. The SBC at Argonne has been home to the world's most productive structural biology beamline since 1998. Joachimiak credits the high productivity, quality and efficiency to the po...Insects and mammals share common fat-building pathway, study suggests
...dded. The findings "suggest that drugs designed to manipulate Hh signaling might have utility in human metabolic disease of altered adiposity, such as obesity and lipodystrophy," agreed Evan Rosen of Beth Israel Deaconess Medical Center in a commentary. But, not so fast, he added. "Though seemingly obvious--any...Tumor cells that border normal tissue are told to leave
...s, the research team has begun to look for ways to manipulate boundary cells to prevent their metastatic behavior. They have seen that disabling some of the genes in the pathway activated in boundary cells stops the cells from leaving the tumor. Cagan's laboratory also has developed a robotic system for screen...OHSU discovery sheds light into how stem cells become brain cells
... neurons at the wrong time. However, since we can manipulate Brg1 expression in stem cells in culture, we now have a powerful way to generate neurons that could be used to replace cells lost in a variety of diseases and conditions that affect the brain and spinal cord. That is our next step." said Sherman. "...Genetic clues to Sodalis deepens knowledge of bacterial diseases
...ic bacteria and put it back into the tsetse fly to manipulate host traits or functions. Information on the blueprint of this organism now gives us a better handle on this applied strategy." When the team sequenced the bacterial genome, they found the hallmarks of an organism transitioning from a free-living st...UCSF study finds nerve regeneration is possible in spinal cord injuries
...roach in efforts to enhance CNS regeneration is to manipulate the biochemical environment of the cells at the site of the spinal cord injury, according to Basbaum. Instead of this type of investigation, Basbaum's team used nervous system manipulation techniques to apply the principles of PNS cell growth capabil...Poison + water = hydrogen. New microbial genome shows how
...ed carbon monoxide deyhydrogenase, that is able to manipulate the poisonous gas. Each form of the machine appears to allow the organism to use carbon monoxide in a different way. Most other organisms that live on carbon monoxide have only one form of this machine. In other words, while other organisms may ha...American Physical Society honors outstanding achievements of two Brandeis scientists
...o computers and TVs, began as research into how to manipulate liquid crystals with electric fields to change their optical properties. Meyer pioneered the ferroelectric properties of chiral liquid crystals, whose molecules are not identical to their mirror image, leading to several new applications. One is a...Biotechnology's newest chemical tool
... new approach provided an unprecedented ability to manipulate DNA experimentally. To demonstrate the technique's potential to alter DNA function, the researchers modified DNA in a position that blocked another enzyme's ability to snip the molecule at its target site. "No one has really thought about possible a...Student scientists create living bacterial photographs
...trol. "If we can hit the cell with a laser, we can manipulate their biology without needles or syringes," says Tabor. "We just turn it on or off with light." Other students and researchers who participated in the project were Laura Lavery, Zachary Booth Simpson, Matthew Levy, Eric Davidson and Alexander Scouras...Bacteria which sense the Earth's magnetic field
...rystals. Although it is difficult to cultivate and manipulate Magnetospirillum gryphiswaldense in the laboratory, as part of his doctoral work Andr Scheffel succeeded in removing the relevant gene from the genome. In this way, mutant bacteria were created which were lacking the MamJ protein. The mutants, surpri...Scientists observe how a close bond activates the immune system
...d because scientists had no suitable techniques to manipulate it. Now that problem has been solved. In a new stu...first time that anyone has been able to physically manipulate the immunological synapse and measure the effect on T cell signaling," says Michael L. Dustin, Ph.D....Scientists map one of biology's critical light-sensing structures
...he lab and their proteins are easier to purify and manipulate than plant proteins. Once isolated, the phytochrome was crystallized and its molecular structure was mapped using a beam of X-rays to develop a three-dimensional picture of the protein. That three-dimensional portrait, which reveals the atom-by-atom......terial can be passed to offspring. "The ability to manipulate male germ-line stem cells and get them to grow and... at UT Southwestern are now working to genetically manipulate those cells. For example, the scientists want to delete specific genes from the sperm stem cells and...