JCI table of contents September 1, 2005
... production of mutant mice in which the Dido gene, mapped to the long arm of human chromosome 20, has been deleted. The authors also examined human MDS/MPD patients and find 100% of them have Dido expression abnormalities. Furthermore, a substantial number of patients with other hematological myeloid diso...Found! First gene associated with myeloproliferative diseases
... production of mutant mice in which the Dido gene, mapped to the long arm of human chromosome 20, has been deleted. The authors also examined human MDS/MPD patients and find 100% of them have Dido expression abnormalities. Furthermore, a substantial number of patients with other hematological myeloid diso...A new view of human-chimpanzee genome differences
...human species." In their analysis, the researchers mapped the draft chimpanzee sequence data onto the human genome sequence as a reference. With their comparative map, they used sophisticated computational analysis to distinguish three categories of segmental duplications -- those found in humans but not in...Neurologix announces positive results of gene therapy clinical trial in Parkinson's disease
...ic nucleus (STN) region of the brain. The STN was mapped using microelectrodes by recording from single neurons as the electrode was slowly moved towards the STN. Once a signature firing pattern was obtained confirming that the electrode was in the STN, the fine-wire electrode was removed, leaving only th...Health of coral reefs detected from orbit
...at 300 m resolution. "Coral bleaching needs to be mapped at the global scale," Dekker adds. "High-spatial resolution satellites can only do it on a few reefs due to cost and coverage constraints. We need a system that has appropriate coverage and revisit frequency, with a sufficient amount of spectral band...Coastal retreat in face of rising sea levels found to be influenced by wildfires
...NASA. In analyses for his doctoral degree, Poulter mapped how plant life is responding to one of the world's highest rates of sea-level rise -- about 30 to 40 centimeters per century -- along the western shoreline of two interconnected North Carolina estuaries, the Pamlico and Albemarle Sounds. As a startin...Stimulating the brain makes the fingers more sensitive
...gion--in this case, the right index finger--can be mapped to allow precise targeting of the rTMS. The authors adjusted the strength of the magnetic field to just below that which triggered a sensory response in the finger, and then applied intermittent pulses of stimulation over the course of about ten minu...RIT partners with leader in remote sensing to enhance homeland security
...of crews on the ground. The wildfire team recently mapped a series of forest fires for the U.S. Forest Service in Western Montana. "RIT is very proud to be chosen as a Leica Center of Excellence," added Stefi Baum, director of the Center for Imaging Science. "We plan to use this software donation to enhance...New imaging method shows early in treatment if brain cancer therapy is effective
...usion, or movement, of water through the brain and mapped the changes in diffusion from the start of therapy to three weeks later. The tumor cells restrict the movement of water, so as those cells die, water diffusion changes. In the study of 34 people with a type of brain tumor called high grade glioma, th...Scientists crack code for motor neuron wiring
... define spinal motor neurons, Dasen and colleagues mapped the timing and location of each of the Hox proteins expressed by motor neurons that project to the wing in chick embryos. "It became clear that these proteins weren't randomly expressed, but were expressed in highly precise patterns that corresponded...Changes to embryos can elicit change in adult fish
...ced by genetic integration." But, when the team mapped the regions of the genome controlling the jaw-opening system, they found that these levers are controlled by different chromosomes. In another part of the study, researchers showed that the gene bmp4 is a major factor in controlling the jaw-closin...Scientists map one of biology's critical light-sensing structures
...e was crystallized and its molecular structure was mapped using a beam of X-rays to develop a three-dimensional picture of the protein. That three-dimensional portrait, which reveals the atom-by-atom configuration of the molecule, is the key to understanding the "nuts and bolts" of how the photoreceptor sen...Loss of fear factor makes timid mouse bold
...t stathmin might contribute to fear came when they mapped the parts of the brain where the gene was most active. They found that stathmin was highly expressed not only in the amygdala, but also in other parts of the brain's fear circuitry. "It was localized not only in the pathway of the learning process, b...Woolly mammoth genome comes to life
...of evolution," says Poinar. "The nuclear DNA we've mapped gives us our first glimpse at both sides of evolution. We can sequence Neanderthals, animals, plants. Basically, if we find a well-preserved specimen, we can sequence its genome." The discovery occurred when Poinar extracted DNA from a well-preserved...Evolutionary shifts in olfactory sensitivities in fruit flies
...pheral and the central olfactory systems have been mapped in detail in D. melanogaster, an important model organism for research. However, nine sibling species of D. melanogaster are less well characterized. One of these species, D. sechellia--as its name suggests, it is endemic to the Seychelles islands--r...Scientist honored with second-most cited research paper of the decade
...d over the years. Minor and his collaborators have mapped over 350 proteins in the last five years in 3-D using the technology. "Out of ten papers most widely cited by The Scientist, nine of them are biomedical and five of those are structural biology, which shows how important this field is," Minor said. ...Life leaves subtle signature in the lay of the land
...oted that limited areas of Mars' surface have been mapped at two-meter resolution, which is better than most maps of the Earth. He is one of the leaders of a National Science Foundation (NSF)-supported project to map in high resolution the surface of the Earth using LIDAR (LIght Detection And Ranging) techn...Genes involved in cell growth and cell division identified
...ch are potential contributors to cancer, have been mapped in a single systematic study. The group led by Professor Jussi Taipale (University of Helsinki and National Public Health Institute of Finland) has identified genes contributing to cell growth and cell division by systematic silencing of most of the ...A new tree of life allows a closer look at the origin of species
In 1870 the German scientist Ernst Haeckel mapped the evolutionary relationships of plants and animals in the first 'tree of life'. Since then scientists have continuously redrawn and expanded the tree adding microorganisms and using modern molecular data, yet, many parts of the tree have remained u...New cell imaging method identifies aggressive cancer cells early
...n the protein's distribution in each cell type and mapped it. This enabled the researchers to verify the changes exhibited by non-differentiated cells that were still multiplying, normal mammary cells and multiplying malignant cells. The ability to see the protein patterns in the nucleus gives scientists on...