Protein prevents detrimental immune effects of bacterial sepsis
...returning to normal by 24 hours. Higher levels of markers of inflammation, and of organ injury, were measured in annexin 1 deficient animals. Altogether, these findings implied that the protective effects of the annexin 1 pathway were activated in the first few hours following toxin administration. In fac...Workers exposed to Libby Vermiculite Ore have high rate of chest wall abnormalities
...f exposure. Pleural plaques are usually considered markers of previous exposure to asbestos fibers. Because of the previous exposure to asbestos, there is a potential increased risk for other asbestos-related lung changes, including scar tissue within the lungs and certain types of cancer such as mesotheliom...Double triumph in stem cell quest
...s derived via therapeutic cloning have the surface markers that make them compatible with the donor's immune system. The biggest question, though, is whether the stembrids really are true ESCs. Verlinsky says the cells express a number of ESC markers. His team has also shown the cells can differentiate int...Study in Royal Society journal on heritability of female orgasm
...n the western North Atlantic. Here we use genetic markers to identify patterns of gene flow for a contiguous distribution of dolphins from the Black Sea to the North Sea. We find genetic populations that are defined by natural habitat boundaries, indicating at least five populations along this geographic r...Digging in the dirt for life's biochemical foundations
...adelphia, tagged nitrogen with easy-to-spot atomic markers and then watched as it traveled from soil to fungus to plant roots. Many had assumed that the fungus would play a modest role. The team found, however, that the fungus acts more like a four-lane highway than a two-track country road in shuttling the...Discovery offers promising lead in prostate cancer diagnosis
...w diagnostic and prognostic cellular and molecular markers for prostate cancer. Dr. Vessella is one of the primary leaders of a research effort at the University of Washington that is defining mechanisms of prostate cancer metastasis. This discovery was the result of a highly coordinated effort by urologists...Diabetes drug ACTOS (pioglitazone HCl) showed anti-inflammatory effects
...s of CRP and interleukin (IL-6), both of which are markers of inflammation in patients with type 2 diabetes. ...gnificantly greater decreases in levels of the two markers in the ACTOS arm. CRP decreased by 6.98 mg/L compared to 1.55 mg/L for placebo (p= 0.001). IL-6 de...Phase I study examines biomarkers for response to erlotinib in glioma
...further prospective studies to identify predictive markers for EGFR-TKI sensitivity in gliomas before their use in clinical decisions."...Marshfield Clinic researchers launch study of environmental causes of Alzheimer's disease
...sease as a first step toward developing diagnostic markers to identify people at risk before they develop the disease. Researchers will study the DNA of Alzheimer's patients from its database of more than 18,000 voluntarily-donated DNA samples. The Marshfield Clinic Research Foundation (MCRF) created the dat...Other highlights in the June 15 JNCI
...ing in the Nurses' Health Study. None of the three markers of iron status--genetic, biochemical, or dietary--was associated with the risk of colorectal adenoma, the polyps that are precursors to most colorectal cancers. The authors conclude that their findings do not support a substantial role for iron in t...Most common lung cancers may begin in newly discovered cells
... of the resulting cancer cells carry the molecular markers of both of the two kinds of cells found in non-small lung cell cancers. In mice, the tumors start deep in the lung, past the trachea and the branches to the lobes. Ciliated cells that catch debris give way to the bronchiolar cells called Clara cells....Runyon award goes to third Vanderbilt-Ingram scientist since 2002
...n Award in 2003 to support his search for specific markers in blood and in the airways that would detect lung cancer early and identify those at risk for developing the disease. Massion works closely with Carbone, Ingram Professor of Cancer Research and professor of Medicine, as an investigator in Vanderbilt...Whole genome promoter mapping - Human Genome Project v2.0?
...easingly turning towards the idea of using genetic markers for diagnosis and prognosis, or determining personalized therapies, so-called pharmacogenetics, but we don't know how these genes are regulated or even related to each other. The identification of such a large number of promoters means that we can be...U-M scientists discover identifying markers for primitive blood-forming stem cells
...rrently, scientists must search for many different markers and use complex procedures to separate rare hemato...Cs, from other cells in a blood sample. Using SLAM markers will streamline the process considerably, says Mark J. Kiel, a student in the U-M Medical School's M...Identifying blood stem cells is a SLAM dunk
...rming, stem cells based on a set of characteristic markers that the cells display on their surface. The eluci...identify specific stem cells by looking at surface markers drawn from a single family of genes. Stem cells are immature cells that can develop into a variety o...JCI table of contents July 1, 2005
...from Harvard study kidney repair in mice harboring markers in their bone marrow. The researchers show that bone marrow-derived cells do not contribute to kidney repair after ARF. The marked cells were not incorporated into the injured kidney. The authors hypothesize that endogenous kidney cells instead ar...Genetic link confirmed between Polynesians and indigenous Taiwanese
...today's Polynesians, and looked for unique genetic markers that occurred in the aboriginal people. They then compared these markers to those found in mainland Chinese, Taiwanese, and other Southeast Asian peoples. Trejaut et al. f......er and if so, whether these species may be used as markers for oral cancer. In order to determine if the salivary microbiota in patients with OSCC would differ from that found in oral cancer-free individuals, Donna Mager and colleagues, from the Forsyth Institute and the Dana Farber Cancer Institute in Bos...... problem might be overcome by developing molecular markers which can identify self-incompatibility genotypes to improve breeding strategies. In collaboration with the Ugandan Kawanda Agricultural Research Institute (KARI), Tumusiime and colleagues have investigated the possible involvement of a group of prot......prove evaluation of anti-cancer drugs, to identify markers for early detection of cancer, and to illuminate the path to novel, targeted treatments," said Lynn M. Matrisian, Ph.D., AACR past president and Ingram Distinguished Professor of Cancer Research at Vanderbilt University in Nashville, Tenn. "Our belie...