New therapy for specific form of leukemia
...mation of white blood cells. The cells in the bone marrow that should develop into white blood cells multiply out of control without fully reaching maturity. These blood cells function inadequately, disrupting the production of normal blood cells. Among other effects, this makes patients more susceptible to...Technique for genetically modifying blood stem cells brings cure for blood diseases closer
... red blood cell. HSCs are parent cells in the bone marrow that give rise to blood cells. The St. Jude team successfully treated beta-thalassemia in mice by using a newly developed vector--or biological ferry composed of DNA housed within a harmless virus--to shuttle a therapeutic gene into th...Gene-altered mouse is model for rare autoimmune syndrome
...f the syndrome in normal mice by transferring bone marrow cells from the genetically altered mice. Bone marrow is the source of immune cells that could cause the disorder. The researchers' experiments with the I...Immune system in a bottle could help prevent flu vaccine shortage
...l be replication of the function of the human bone marrow and thymus. Besides University of Texas Medical Br...tchinson Cancer Center. Later, the artificial bone marrow and thymus will be integrated with other elements of the human immune system being developed in the ...NIH funds rare childhood disease to provide insights into the origins of adult cancer
...an inherited blood disorder that prevents the bone marrow from producing sufficient red blood cells, which carry oxygen to all tissues in the body. Those red blood cells that are produced are often large in size and do not function properly. All other blood cells -- white blood cells and platelets -- are us...Human embryonic stem cells promising for replacement of blood supply
... any viruses. They might also be a source for bone marrow transplants, especially for those patients who do not otherwise have an appropriately matched donor." This process is also significant because the blood cells were developed without the use of animal serum, which was previously thought to be essentia...Other highlights in the November 3 JNCI
...esenchymal stem cells, which are derived from bone marrow cells, could be used to deliver interferon beta to tumors. They suggest that mesenchymal stem cells could be an effective platform for delivering therapeutic proteins to specific cancer sites. Contact: Laura Sussman, M. D. Anderson Cancer Center, 71...New program examines stem cells' potential to repair, replace damaged tissue
...will isolate cells from umbilical cord blood, bone marrow and fat and study them in vitro, Dr. Isales says. They also will examine the cells in tissue of different ages to see how they change and what responses generate new cells. "Maybe as cells age, they lose their ability to respond to vibration," he say...Joslin and Stanford researchers find key clues to muscle regeneration
...ary to previous studies, precursor cells from bone marrow or other blood-forming tissues did not change thei...ps have reported that stem cells found in the bone marrow could repair damaged muscle cells. This had raised hopes that the well-characterized blood-forming s...New studies regarding the efficacy of antioxidants and their impact on standard cancer treatment
...hat examines oxidative damage directly in the bone marrow of children with ALL (acute lymphoblastic leukemia) using (8-oxo-dG) as a biomarker for oxidative stress. One important result is the discovery that the levels of individual antioxidants vary according to disease status. (Deborah D. Kennedy, Regina ...JCI table of contents, November 15 2004
...thereafter, definitive therapy in the form of bone marrow stem cell transplantation can result in a survival...cell transplantation (involving transplanting bone marrow from a healthy sibling or other donor whose tissue type closely matches that of the patient's) is no...Army-funded effort examines androgen's role in bone loss
...y for asthma, alcoholism, chronic smoking and bone marrow malignancies are believed to cause androgen defici...nes, such as the femur, decreased formation on the marrow surface inside the bone, reduced bone loss and low bone "turnover." Biomechanical analysis showed th...University of South Florida designated Center of Excellence by Huntington's Disease Society
... is planning to study whether stem-like adult bone marrow cells administered intravenously may delay the onset of Huntington's disease in mice genetically engineered to have symptoms of the disease. Such cells have already shown promise in animal models for brain injuries caused by stroke and trauma. ...JCI table of contents, December 1 2004
... or not? The use of stem cells obtained from bone marrow for the treatment of some skeletal or heart diseas...tissue in order to effect repair. A subset of bone marrow cells, called bone marrowderived side population (BM-SP) cells, make up only 0.01-0.05% of whole bon...New drug sidesteps Gleevec resistance in human trials
...f mice with CML. In tests with cultured human bone marrow cells, the researchers showed that the drug inhibits the proliferation of bone marrow progenitor cells that are positive for BCR-ABL in patients who are resistant to Gleevec. "The bottom...JCI table of contents, December 15 2004
...bits caspase-3 activity, in addition to human bone marrow stromal stem cells (BMSSCs) treated with a caspase...of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells AUTHOR CONTACT: Songtao Shi National Institute of Dental and Craniofacial Researc...Combined stem cell-gene therapy approach seen as potential treatment for cystic fibrosis
...proof of principle that a cell-based therapy using marrow stromal stem cells is both a feasible and promisin...some studies have suggested the potential for bone marrow derived stem cells to differentiate into airway epithelial cells, Dr. Kolls and his co-authors have ...JCI table of contents, 3 January 2005
...sly enter the blood and then rapidly return to the marrow but the molecular events that regulate the movement of these primitive cells are largely unknown. In the January 3 issue of the Journal of Clinical Investigation, Tsvee Lapidot and colleagues from The Weizmann Institute of Science in Israel describe ...Stem cell therapy for ailing hearts
...marily on immature cells harvested from adult bone marrow and skeletal muscle with mixed results. "Althoug...d are less mature than those taken from adult bone marrow and skeletal muscle," Dr. Henning said. "Cord blood stem cells may be more amenable to repairing he......od, the spleen is turned on to supplement the bone marrow in replenishing your blood supply. We may find that the spleen kicks in to help with many more biological emergencies. What has been considered a practically unnecessary organ may actually provide critical healing cells," says Faustman, an associat...