Amgen investigational therapy, AMG 162, increased bone mineral density with twice yearly injection
...steoporosis is a disease characterized by low bone mass and structural deterioration that causes bones, most commonly of the hip, wrist and spine, to become brittle and susceptible to fracture. Approximately 200 million women worldwide suffer from osteoporosis, according to the International Osteoporosis......osed the bottleneck may have occurred because of a mass die-off of early humans due to a globally catastrophic volcanic eruption. Others believe the population bottleneck seen in human genes happened because only a small group of human ancestors left Africa in the second wave 150,000 to 50,000 years ago, ...Endangered frogs coexist with fungus once thought fatal
...ndings do not exonerate the fungus as the agent of mass declines, they can rule out the possibility that the fungus caused the decline, then vanished from the area, allowing frog populations to recover. Although it's possible that B. dendrobatidis did not cause the initial T. eungellensis declines, su...Protein energy profiles offer clues about amyloids
...ns of misfolded proteins stick together and form a mass that the body can't get rid of on its own. Doctors don't yet understand whether amyloids cause disease or result from it, but the fact that they are present in very different diseases affecting millions of people points to the need for improved under...Scientific organizations unite to influence science policy and promote the ERC
...-signed by 52 European scientific organizations. A mass petition of this kind on science policy is almost unheard of in Europe. The conference will also feature the Founding Meeting of ISE, the first independent body established to provide a common voice and an action mechanism for European science organi...New risks for bladder cancer identified by MIT team
...fic products that can be detected and measured via mass spectrometry. "So what popped out of this was actually pretty startling," Tannenbaum said. "Three of the nine compounds were indeed found to be significant risk factors for bladder cancer in nonsmokers. And except for one, none of those nin...Acoustics meeting in San Diego
...known as QRT 2000, used ultrasound to measure bone mass in the women's heels. The researchers hope the low-cost, handheld device could be used by primary care physicians globally, including in the developing world, to routinely test the bone health of patients. (1pBB11). Monitoring the healing of a bone ...New study on smallpox in monkeys reveals tactics of a killer
...s. The findings shed light on how the virus caused mass death and suffering, and will help point the way to new diagnostics, vaccines and drugs that would be needed in the event of a smallpox bioterror incident. The study, led by David Relman, M.D., of Stanford University, is now online in the Proceedings...Muscling in on a deadly cancer
...made a second way: Muscles made earlier gain added mass because of satellite cells, which are stem cells destined to make muscle. Rhabdomyosarcomas long were thought to arise in satellite stem cells. Yet when the researchers activated the cancer-causing Pax3:Fkhr gene in mouse muscle sat...Mechanism discovered for muscle wasting seen in diabetes, AIDS and other diseases
...r six months of therapy, their body weight, muscle mass and muscle fiber size were nearly normal. In a pr...on. In these latter mice, body weights and muscle mass were essentially normal throughout life. The researchers also studied the effects of blocking NF...Purdue chemists give an old laboratory 'bloodhound' a sharper nose
... team, including R. Graham Cooks, has improved the mass spectrometer, a device well known to chemists for ...xplosives or drugs inside packages. But while most mass spectrometers are unwieldy, cabinet-sized machines that require samples to undergo hours of intensiv...Scientists identify new cause of obesity
... in the body at concentrations proportional to the mass of body fat. It initiates the signaling pathway that determines whether or not MC4R will trigger the body's urge to eat. MC4R is known as a G-protein coupled receptor (GPCR), about 350 of which are present in the human genome. These receptor's sense ...Diabetes hikes risk for liver, pancreatic cancers
...d that these findings were independent of the body mass index of the individuals. In this study, diabetics did not have increased risks for other cancer types, including melanoma, non-Hodgkin's lymphoma, cancers of the esophagus, stomach, colon, rectum, lung, prostate, bladder, and kidney. Rousseau,...Discovery might improve design, effectiveness of anti-cancer drugs
...roduced as a fine spray into a vacuum created in a mass spectrometer in the laboratory, normal solvent mol...cted a water molecule inside a protein molecule by mass spectrometry, he said. A report on the research appears in the latest issue of the Proceedings of th...Globetrotting pollutants turn up on Toronto street
...esearchers used a device known as a laser ablation mass spectrometer (LAMS), which pulls in air from College Street and accelerates the pollutants to close to the speed of a bullet. As a particle passes by two lasers, sensors calculate its exact speed and tell the LAMS when to fire a third, high-powered l...Other highlights in the November 3 JNCI
...cancer, and there has been some evidence that body mass at younger ages, weight change, height, and physic... cm (5 feet 3 inches) in height. Women with a body mass index (BMI) of 30 or greater had a higher risk compared with women with a BMI between 20 and 22.9. B...ORNL project earns top honor from Southeast tech transfer group
...transfer were the MicroTrap MS microscale ion-trap mass spectrometer and the miniature californium-252 neu...urce for cancer therapy. The microtrap mass spectrometer is a microscale ion trap device that can analyze the composition of a substance through...Tiny paddle oscillator senses the mass of a virus
...k in which similar devices were used to detect the mass of a single bacterium, is reported in a paper, "Vi...researchers calculated that the minimum detectable mass for a six-micrometer paddle would be .41 attograms (an attogram is 1/1000th of a femtogram.) This o...Mayo researchers define celecoxib pathways and mechanisms for tumor reduction
...mmatory drug Celebrex, or celecoxib, reduces tumor mass by encouraging cell death and discouraging both ce... celecoxib caused reduction in mammary gland tumor mass that was associated with increased programmed cell death, or apoptosis, in the breast tissue of the ...Young adults who maintain their weight have lower risk factor levels for heart disease
...ctors. Investigators found that on average as body mass index, an indicator of obesity, increased, adverse changes in these cardiovascular disease risk factors occurred. Over the 15 years of the study, these changes produced substantial differences in risk factor levels. Normal-weight men who maintained...