VCU Massey Cancer Center researchers find new agent inhibits Leukemia cell survival
A team of researchers at Virginia Commonwealth University Massey Cancer Center has discovered an entirely new mechanism of action for a novel pharmacological agent currently in clinical trials in patients the kinase inhibitor BAY 43-9006 which was designed to disrupt the survival pathways of tumor cells. ... ..."This agent was originally designed to inhibit the Raf-1 pathway, which is frequentl...Massey researchers induce cell death in leukemia
... In this study, led by Steven Grant, M.D., Massey's associate director of translational research, interactions between bortezomib and romidepsin (Gloucester Pharmaceuticals) and bortezomib with belinostat (aka PXD101 from CuraGen Corporation and TopoTarget A/S), were examined in h...VCU Massey Cancer Center researchers identify a new class of anti-cancer drugs based on platinum
Researchers at Virginia Commonwealth University's Massey Cancer Center have created a new platinum-based, anti-cancer agent able to overcome acquired drug resistance by first modifying the way it is absorbed into cancer cells and then attacking the DNA of those cancer cells. ...... The findings may help researchers design a new generation of anti-cancer drugs that selectively target cancer cells,...VCU Massey Cancer Center study shows enzyme linked to spread of breast cancer cells
RICHMOND, Va. (Aug. 19, 2005) Researchers at the Virginia Commonwealth University Massey Cancer Center have found a new signaling component that influences movement of human breast cancer cells toward epidermal growth factor....... In the August issue of the Journal of Biological Chemistry, researchers showed that epidermal growth factor, which plays a critical role in breast cancer progression,...Massey Cancer Center researcher helps to identify a piece of the cancer puzzle
Richmond, Va. (May 11, 2005) -- A structural biologist from the Virginia Commonwealth University Massey Cancer Center, in collaboration with researchers at Memorial Sloan-Kettering Cancer Center, has identified the crystal structure of a protein that plays a role in supplying nutrients to solid tumors. ......This identification may help researchers gain a greater understanding of the cell signal...