Forsyth scientists gain new understanding of adult stem cell regulation
... Institute scientists have discovered an important mechanism for controlling the behavior of adult stem cells. Research with the flatworm, planaria, found a novel role for the proteins involved in cell-to-cell communication. This work has the potential to help scientists understand the nature of the messages ...Molecule blocks gene, sheds light on liver cancer
...rology. Our findings essentially describe a new mechanism used by cells to regulate PTEN, says principal investigator Tushar Patel, professor of internal medicine, director of hepatology and a liver-cancer specialist at Ohio State University Medical Center. They show that high levels of miR-21 block the ...Discovery in plant virus may help prevent HIV and similar viruses
...n," he said. "This must also reflect a fundamental mechanism for transcription inherited by these viruses." Humans and organisms used for research, such as fruit flies and the tiny wormlike organism Caenorhabditis elegans, have only one gene in the protein complex that retroviruses use to activate transcript...Fish eyes could hold clue to repairing damaged retinas in humans
...egeneration," says Dr Limb. "Once we know how this mechanism works, we will be much closer to developing a treatment." The UCL researchers hope that the research may lead to a treatment within five to ten years, for cells isolated from a person's own eye. However, the need to overcome the immune response fo...Huntington's disease study shows animal models on target
...ctivity of genes in affected neurons. This disease mechanism is a promising new avenue for research into the causes of neuronal death and a novel potential approach for treatment. Led by EPFL professor Ruth Luthi-Carter, and involving collaborators from six countries, the current study found a marked resembl......s to resolve the current conflict over the precise mechanism of miRNA action. Dr. Yokoyama and colleagues developed a cell-free system using extracts from human epithelial cells that were engineered to over-express specific miRNA pathway components. They introduced exogenous let-7 miRNAs and monitored its e...Nottingham biosciences million pound injection
...ourages new tissues to form. The unique scaffold mechanism also assists the delivery of stem cells and drugs without compromising their effectiveness. This offers a substantial opportunity to deliver a cure to patients with bone, liver, heart or nerve tissue defects. Professor Kevin Shakesheff, Chief Scien...New target for HIV/AIDS drugs and vaccine discovered
...AIDS treatment: the understanding of Nef function, mechanism of action, and cellular partners might aid the discovery of suitable drugs able to block the activity of this smart protein. Quaranta added, An exciting possibility is the design of a vaccine including a mutated Nef protein unable to assist the virus...A friendly foe -- Bacteria residing in the gut boost immune response to tumors
...ion. This surprising result indicated that another mechanism for the efficacy of TBI also exists. They found th...e resulting transient bacterial infection is a key mechanism driving the increased reactivity of tumor-specific CD8+ T cells and subsequent tumor regression in m...JCI table of contents -- July 26, 2007
...ion. This surprising result indicated that another mechanism for the efficacy of TBI also exists. They found th...e resulting transient bacterial infection is a key mechanism driving the increased reactivity of tumor-specific CD8+ T cells and subsequent tumor regression in m......g binding probabilities increases. This simple mechanism is coined 'conformational proofreading' and may explain the observed deformations in many biological recognition systems. Furthermore, conformational proofreading may turn out be a crucial factor affecting the evolution of bio-logical systems, and it...Scientists find stem cell switch
...environmental cues. We predict that this is the mechanism plants use to detect how tough or soft the soil is around them, said Professor Dolan. As in humans, plant stem cells are the source of all growth. The defining characteristics of stem cells are that they are able to either regenerate themselves or ...Gene-transcription machinery seen poised for action, held in check until needed
...own the linear DNA molecule. The data outline a mechanism by which sets of critical genes could be prepared for nearly instantaneous activation in response to stress or other vital needs. Embryonic stem cells, for example, are known to have numbers of genes held in this state of readiness. In their invest...Study points to new way to predict death risk from torn aorta
...ortic dissection patients, and a new model for the mechanism behind that risk. Their model focuses on a phenomenon that can easily be seen on modern medical-imaging scans: the presence of blood clots in the channel created when the layers of the aorta separate like two layers of an onion. This channel, call...How to structure a complex body plan
...ptive plasticity, or regeneration, is an efficient mechanism by which isolated fragments of branching coral species cope with external environmental forces....Fruit fly gene from 'out of nowhere' is discovered
...uences generated by transposons may be part of the mechanism for creating new genes, as the duplications provide more chances for a gene to evolve....A novel molecular dictator 'with a conscience' discovered
...rs have uncovered an important naturally occurring mechanism in the body where "bad" cells that cause blockages...ar assassin" drug technology, describes this novel mechanism he discovered as a molecular dictatorship with a conscience. "The dictator is a specific gene su...New clue into how diet and exercise enhance longevity
...hemicals called free radicals. Our findings put a mechanism behind what your mother told when you were growing upeat a good diet and exercise, and it will keep you healthy, said White. Diet, exercise and lower weight keep your peripheral tissues sensitive to insulin. That reduces the amount and duration of in...Scientists a step closer to understanding how anaesthetics work in the brain
... a clearer picture than ever before of the precise mechanism by which anaesthetics work. This kind of research, explains Professor Franks, is important because understanding exactly how anaesthetics work may pave the way for the development of a new generation of anaesthetics which solely affect specific an......er proteins are involved in the activation. The mechanism underlying this control has yet to be fully characterized, said White. Our data shows that as EGFRvIII is activated, c-Met is activated as well. Whether its direct, or indirect, is something that we are currently deciphering. The new knowledge of c...