JCI table of contents October 1, 2005
...n light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo. AUTHO... resorption requires an understanding of how TRAF6 mediates RANK-induced osteoclastogenesis. In a paper appearing online on September 22 in advance of print pu...Greasing interferon's gears may pave way to greater therapeutic benefits, fewer side effects
... 29, 2005 -- Interferon -- a critical protein that mediates the body's defense against a wide variety of infectious agents and tumors -- may soon have greater therapeutic value as the result of a new study by researchers at Washington University School of Medicine in St. Louis. "Essentially, we found a way t...Joslin study sheds light on birth defect cause in pregnant women with diabetes
...goal was to see whether oxygen deprivation is what mediates the effects of high glucose on the embryo in pregnant diabetic mice. Dr. Loeken's lab had previously found that inducing high blood glucose levels in pregnant mice suppressed Pax3 expression in embryos. Pax3 is a gene required for healthy formation o...Gene that helps mosquitoes fight off malaria parasite identified
...ia to humans. "An immune-responsive serpin, SRPN6, mediates mosquito defense against malaria parasites" was written by Eappen G. Abraham, Sofia Pinto, Anil Ghosh, Dana L. Vanlandingham, Aidan Budd, Stephen Higgs, Fotis C. Kafatos, Marcelo Jacobs-Lorena and Kristin Michel. Abraham, Ghosh and Jacobs-Lorena are ...JCI table of contents December, 2005
...physema. However, the mechanism whereby IFN-gamma mediates these tissue changes has not been clear. In a paper appearing online on November 10 in advance of print publication of the December issue of the Journal of Clinical Investigation, Jack Elias and colleagues from Yale University show that that a recept...JCI table of contents: December 2005
...gets for inflammatory bone erosion. TITLE: M-CSF mediates TNF-induced inflammatory osteolysis AUTHOR CONTACT: Steven L. Teitelbaum Washington University School of Medicine, St. Louis, MO Phone: 314-454-8463 Fax: 314-454-5505 E-mail: teitelbs@wustl.edu View the PDF of this article at: https://www.t...New technique helps researchers determine amino-acid charge
...ic acetylcholine receptor, a membrane protein that mediates voluntary muscle contraction. "Our paper has implications that are specific to this receptor, but many of the findings can be extended to several other membrane proteins," said Claudio Grosman, a professor of molecular and integrative physiology at I...Learning about sex from an elegant worm
...HIM-8 binds to the X chromosome Pairing Center and mediates chromosome-specific meiotic synapsis," by Carolyn M. Phillips, Chihunt Wong, Needhi Bhalla, Peter M. Carlton, Pinky Weiser, Philip M. Meneely, and Abby F. Dernburg, appears in the 16 December, 2005 issue of Cell. "A conserved checkpoint monitors mei...Sea slug mixes chemical defense before firing at predators
...ous research, Derby's team determined that escapin mediates the chemical reaction with L-lysine and L-arginine that results in the defensive secretion. Using a variety of chemical and molecular techniques, the scientists identified L-lysine and L-arginine in the opaline gland, which produces the sticky white ...Gladstone researchers hone in on differentiation of heart stem cells
...ts receptor, Notch. The binding of Delta and Notch mediates development of many kinds of tissues and is involved in differentiation of cardiac stem cells into muscle cells. "Given the importance of understanding cardiac progenitor determination and differentiation in current cardiac regenerative medicine, our...Algal protein in worm neurons allows remote control of behavior by light
...at lacked the C. elegans ion channel that normally mediates backing behavior in response to touch. The researchers performed electrophysiological experiments to show that the effects they observed were indeed due to the inward flow of ions caused by activation of the ChR2 protein by light; this inward ion flo...JCI table of contents: December 22, 2005
...s such as asthma. It is widely believed that IL-13 mediates its proinflammatory effects via the STAT6 signalin...RK1/2 mitogen-activated protein kinase selectively mediates IL-13induced lung inflammation and remodeling in vivo AUTHOR CONTACT: Jack A. Elias Yale University ...Protein found to control tumor growth in certain breast cancers
...ptor in vitro, further indication that the protein mediates the sensitivity of hormone-dependent breast cancer cells to tumorigenesis. "While still preliminary, our data adds another critical function to Nod1," Ulevitch said, "namely its ability to regulate the growth of estrogen-sensitive tumors formed by sp...Mice lacking social memory molecule take bullying in stride
...ain (ventral tegmental area), the relevant circuit mediates responses to emotionally important environmental stimuli via release of dopamine. Activity of this neurotransmitter is regulated in the circuit by brain derived neurotrophic factor (BDNF), which is known to play a key role in memory ( http://www.nim......velopment, as well as a key downstream target that mediates the tumorigenic roles of these three cathepsins. Dr. Joyce and colleagues found that E-cadherin (a known inhibitor of tumor invasion) is a target substrate of cathepsins B, L and S but not cathepsin C. Their evidence suggests that cathepsins B, L an...JCI table of contents, February 16, 2006
...wall cells (as opposed to immune cells themselves) mediates the influx of white blood cells, called neutrophils, into the lung during acute bacterial infection. The researchers stimulated neutrophil influx to the lungs of mice by having the mice breathe in a bacterial sugar called lipopolysaccharide (LPS). As...Drawing a crowd: Understanding the signals that bring inflammatory cells into the lung
...wall cells (as opposed to immune cells themselves) mediates the influx of white blood cells, called neutrophils, into the lung during acute bacterial infection. The researchers stimulated neutrophil influx to the lungs of mice by having the mice breathe in a bacterial sugar called lipopolysaccharide (LPS). ...JCI table of contents, February 23, 2006
...dence that this form of the molecule independently mediates any pathological immune response. Now, in a study ...rm of this protein released by activated platelets mediates rejection, providing a link between trauma and acquired immune system activation. TITLE: Platelet-de...JCI table of contents, March 16, 2006
...t only alters expression of interleukins, but also mediates a transition in the development of immune T cell types. TITLE: The neutrophil-activating protein of Helicobacter pylori promotes Th1 immune responses AUTHOR CONTACT: Marina de Bernard Venetian Institute of Molecular Medicine, Padua, Italy Phone......ound evidence in mice that the gene STAT3 in liver mediates the effects of brain insulin. The STAT3 response depends upon interleukin-6, a chemical involved in the body's reaction to stresses, they reported. Earlier evidence by the researchers showed that the gene STAT3 controls glucose balance by limiting th...