Tag: "metabolism" at biology news

Researchers find new clues to biochemistry of 'anti-aging'

...ve been damaged, and the enzymes affect aspects of metabolism responsible for controlling insulin secretion." De...urce." Denu says it's not clear what role acetate metabolism may play in the little-understood sirtuin molecular system that seems to confer so many advantages, ...

Rare disease's gene may illuminate major disorders

... and other toxins. When the gene is mutated, lipid metabolism is altered and iron builds up, triggering disease....rs say, which is significant because similar lipid metabolism changes are seen in neurodegeneration associated with ischemia from stroke, spinal cord trauma, head...

Calorie restriction may prevent Alzheimer's through promotion of longevity program in the brain

...s which influence a variety of functions including metabolism and aging. Dr. Pasinetti and colleagues used an experimental mouse model to demonstrate that beta-amyloid peptides in the brain can be reduced by subjecting the mice to dietary caloric restriction, primarily based on low carbohydrate food. Conversely...

Adult stem cell research at UB targets damaged hearts

...eries adapt to this deprivation by down-regulating metabolism while remaining functionally viable. Previous work in UB's Center for Cardiovascular Research employing the center's novel swine model of hibernating myocardium has shown that restoring normal blood flow to these "hibernating" regions improves funct...

Researchers attack tumor cells by exploiting dependency on sugar metabolism

...st that inhibition of a specific aspect of glucose metabolism may represent an attractive and potentially well-t...ls. These data suggest that alterations in glucose metabolism in cancer cells are linked with changes in mitochondrial physiology and that LDH-A plays a critical ...

Scientists take 'snapshots' of enzyme action

...iminated and what goes wrong in cases where normal metabolism fails. The research will be published online the week of June 12, 2006, by the Proceedings of the National Academy of Sciences. According to Brookhaven biologists Eswaramoorthy Subramaniam, the lead author, and Subramanyam Swaminathan, who led the re...

Gazelles shrink liver and heart to reduce oxygen consumption during drought

...zelles may store fats in the brain to secure brain metabolism during prolonged food and water deprivation. Since 1928, Physiological and Biochemical Zoology has presented original, current research in environmental, adaptational, and comparative physiology and biochemistry....

Diabetes research takes wing thanks to long-lived fruit fly

...ulin, preparing the body for stress by slowing its metabolism and limiting its energy output. It might also offer a new way to control insulin production. Like JNK, the insulin receptor is also involved in determining life span. Caloric restriction limiting the calories an organism ingests generally increases...

Getting ahead of cancer: SPECT/Spiral CT technology enhances bone scanning, earlier diagnosis

...dings. Bone scintigraphy reveals changes in bone metabolism rather than changes in bone structure. The tracer ...ministration of the tracer, information about bone metabolism and blood flow versus soft tissue (muscle, ligament, tendon) can be obtained. Spiral CT scanning is ...

SNM recognizes contributions of Walter Wolf with 2006 Georg Charles de Hevesy Nuclear Pioneer Award

...ive studies of drug biodistribution, targeting and metabolism using both nuclear medicine imaging (including pos... work in determining the absorption, distribution, metabolism and elimination of radioactive compounds in the human body. His work led to the foundation of nuclea...

Study finds racial differences in response to treatments for advanced colon cancer

...e results also suggest that genetic differences in metabolism of chemotherapy drugs may play a role. "The aim of...oding for key enzymes involved in drug activation, metabolism and disposition," Goldberg said. The findings were presented as an abstract Sunday (June 4) at the A...

UB scientist publishes first human microbiome analysis

...otential to carry out necessary functions of human metabolism showed that both had ample concentrations of essen...transport and metabolism, amino acid transport and metabolism and several other functions. "This metagenomics analysis begins to define the gene content and enco...

Gut reaction: Researchers define the colon's genome

...nce of beneficial microbes, can trigger defects in metabolism and development of diseases such as inflammatory bowel disease." As in studies of other animals, the scientists began by collecting droppings. They collected fecal samples from two anonymous, healthy adults who'd gone without antibiotics or other me...

DOE JGI finishes 100th microbial genome

...ance, and many other aspects of the physiology and metabolism of the green sulfur bacteria." The search for microorganisms that can inform solutions to energy and environmental challenges can go to the extremes--the boiling hot pools in Yellowstone National Park, for instance--and lead to new biotechnology prod...

Ready, set, mutate and may the best microbe win

...y protein that the bacteria needed to regulate its metabolism at high temperatures. They grew the bacteria for one month in fermentor, raising the temperature a half degree Celsius each day. Over a span of 1,500 generations, the percentage of mutant strains inside the fermentor ebbed and flowed as the single-ce...

Joslin-led study reveals new findings on insulin signaling in the liver

...two distinct mechanisms to control glucose and the metabolism of blood fats (lipids) in the liver, a new Joslin ... serious health problems: the breakdown of glucose metabolism that can lead to type 2 diabetes, and the malfunction of lipid metabolism contributing to metabolic ...

Methane-belching bugs inspire a new theory of the origin of life on Earth

...istry may harbor the molecular fossil of the first metabolism on Earth. While other microbes make methane from c... have evolved into a free-living cell, and how the metabolism of acetate to methane could have evolved based on the pathways they discovered. The genomic and prot...

Gladstone scientists prove neurons produce Alzheimer's-linked apolipoprotein E

...te that those fragments may interfere with glucose metabolism in the mitochondria (small intracellular organelles responsible for energy production, among other functions), leading to mitochondrial dysfunction and neuronal cell death. The paper, "Profile and Regulation of Apolipoprotein (Apo) E Expression in C...

Gene linked to rare disease activates fat breakdown

...ngs elucidate the mechanism underlying healthy fat metabolism and explain why people with the genetic condition ...how CGI-58 activation of the lipase affects energy metabolism in various tissues. As disruption of the equilibrium of lipid synthesis and degradation can result i...

Eat less, weigh more? Enzyme makes lean mice 'susceptible' to dietary fat

...bly in the region that controls hunger, thirst and metabolism - the hypothalamus. Proteins similar to CPT1c are known to help break down fat to release energy to feed cells. Mice lacking the CPT1c gene are the same length as their littermates who carry normal copies of the gene but on average weigh 15 percent...

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(Date:8/27/2014)... manipulating neural circuits in the brain of mice, ... memories. The research, led by Howard Hughes Medical ... of Technology (MIT), reveals that the connections between ... information about an experience and the part of ... that experience are malleable. , Altering those ...
(Date:8/27/2014)... greatest risk to Europe based upon a proxy for ... using a ,big data, approach to scientific research. , ... Global Health ranked the top 100 pathogens affecting humans ... system which, they believe, will help governments across the ... infectious diseases, including as a result of climate change, ...
(Date:8/27/2014)... is available in German . ... the most common inherited disease affecting the peripheral nervous ... Max Planck Institute of Experimental Medicine and University Medical ... cells is impaired in rats with the disease. These ... known as myelin, which facilitates the rapid transfer of ...
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