Obese women with early-stage breast cancer more likely to die than women of normal weight
... groups, respectively. Five-year rates of distant metastasis were 7 percent for women of normal weight, 6 percent for overweight women and 10 percent for the obese group. "Because the prevalence of obesity increases with age, as does the risk of breast cancer, interventions that enhance weight control may have...S1P1 essential for tumor growth and is blocked by RNA interference
Tumor growth and metastasis require new blood ves-sel growth, a process called angiogenesis. There are many factors involved in the nor-mal growth and stabilization of new blood vessels. One of these, sphingosine 1-phosphate receptor 1 (S1P1), is required during embryonic devel...Sandbagging cancer in the bloodstream
...he possible new treatment strategy for cancer cell metastasis stems from several years of basic research conduct...s also acquired a high degree of resistance to the metastasis of tumor cells. This suggests a possible new avenue to explore therapeutically in humans. Src kinase...JCI table of contents November 1, 2004
...rins could play a role in the development of tumor metastasis as they have been shown to block the migration of ...data indicate that SEMA3F is a strong inhibitor of metastasis that affects both tumor and stromal cells, which suggests that it may have therapeutic potential. TI...Mayo researchers define celecoxib pathways and mechanisms for tumor reduction
... of mice, celecoxib appeared to completely inhibit metastasis of the breast tumor. The study employed a m...esembles spontaneous breast cancer progression and metastasis in humans. "The MTag mouse model for human metastatic breast cancer is a helpful and importan...Encouraging results from validation study of trial of personalized treatment in breast cancer
...and Adjuvant Online) in predicting time to distant metastasis (the development of tumors in other parts of the body) and overall survival. The statistical analysis was carried out independently of Amsterdam by a statistical team in Belgium, in collaboration with a bioinformatics group in Switzerland. Dr.Picca...MIT team engineers new approaches to understanding malaria, more
...in naturally occurring biomolecules may affect the metastasis of that disease. Ultimately, the work could lead to better treatments for these and other diseases. Suresh's coauthors are graduate student John P. Mills and research scientist Ming Dao of MIT's Department of Materials Science and Engineering, Profes...JCI table of contents, December 15 2004
... describe two additional roles of platelets in the metastasis of breast and ovarian cancer cells to the bone. Th...mation. Treatment of these mice after initial bone metastasis with Intergrilin, an inhibitor of platelet aggregation, resulted in decreased circulating LPA levels...JCI table of contents, 3 January 2005
...predicts likelihood and location of spread Cancer metastasis the transfer of disease from one organ to another...ecific organs. Furthermore, they identified a bone metastasis gene expression signature that was able to distinguish between primary breast carcinomas that prefer...Other highlights in the January 5 JNCI
.... Specifically targeting VEGFR-3 may inhibit tumor metastasis by preventing lymphatic vessel growth by the tumor... inhibit lymphangiogenesis in tumors and to reduce metastasis to lymph nodes. These observations suggested that antagonists of VEGFR-3 activation could inhibit l......ut also the proliferation of tumorous cells. Thus, metastasis extends even further and the patient does not bene...therefore, in cancerous cells. And this is why the metastasis regenerates. Thus, in order to obtain beneficial effects using IL-2, the glutation in tumorous cells...A more accurate screening test for prostate cancer?
...rotein that stimulates cell migration and promotes metastasis in prostate cancer. Unlike PSA, it is produced almost exclusively by cancer cells, and is detectable in urine. In this study, Zetter and colleagues compared thymosin 15 levels in urine samples from 121 men with prostate cancer, 15 men with other ...Study of genomic DNA leads to new advances in cancer diagnostics
...ions must be aberrant for abnormal cell growth and metastasis to occur. Indeed, Dr. Maniotis and his colleagues found that the extracellular matrix (ECM), or the microenvironment surrounding the cell, influenced whether the cell's chromatin was sensitive or resistant to Alu I. The group also implicated the ce...Scientists announce world's most sensitive cancer test
...e first time that anyone has been able to diagnose metastasis without locating the secondary tumours. Secondary tumours can be difficult to find, and women with breast cancer often undergo precautionary mastectomy or whole-body chemotherapy. The optical stretcher will allow many women to avoid the emotional and...New approach to cancer treatment shown to be highly effective
... that lysolipids (like S1P) play in the growth and metastasis of cancer cells. According to Dr. Mills, the most deadly, multi-resistant cancers--including lung, breast, melanoma, and ovarian cancers--responded well to the SphingomabTM approach of targeting S1P. The SphingomabTM treatment not only blocked the...Method holds promise in identifying markers of non-metastatic vs. metastatic breast cancer
...es was injected into the mammary pads of mice, and metastasis was monitored by examining migration of cells to t...lds great promise in identifying genes involved in metastasis of other cancers and may lead to better prognostics and therapeutics. "Metastatic spread of cancer...The Molecular Profiling Institute, Inc. launches MammaPrint for breast cancer patients
...have a poor tumor signature - with a high risk for metastasis if untreated.(6) "This new test enables the oncologist and breast surgeon to more accurately determine who should be treated, helping us to maximize survival and decrease morbidity" said Dr. David Loesch, Physician Director for Clinical Research...Other highlights in the June 1 JNCI
...e mouse equivalent of the human gene NM23 promotes metastasis in a mouse model of liver cancer, according to a n...onclude that a lack of NM23-M1 expression promotes metastasis in this animal model of liver carcinogenesis. Contact: INSERM Press Office, 33-1-44 23 60 98, press...Eleven gene 'signature' reliably predicts cancer prognosis
...an cancers predicts a marked predisposition toward metastasis and a high probability of poor therapy outcome. In an accompanying commentary, Gordon Mills and others write, "such a "magic marker" [will] have a major impact on patient care."......an cancers predicts a marked predisposition toward metastasis and a high probability of poor therapy outcome. In an accompanying commentary, Gordon Mills and others write, "such a "magic marker" [will] have a major impact on patient care." TITLE: Microarray analysis identifies a death from cancer signature pre...