Commandeering cellular machinery: recognition mechanism to detect small molecules
...ied RXR.) Though the goal was 32,768 variants, the method actually produced approximately 380,000 samples which would have been impossible to test using conventional screening methods. However, Doyle and his research team used a new protein engineering technique known as chemical complementation that allo...Stanford cooling tool may improve performance of athletes, soldiers
...formance. Two Stanford biologists have developed a method for cooling that maximizes heat transfer through the palms of the hands. The idea is to engorge confluences of arteries and veins located there by mechanically drawing blood into them. The technology was used by some athletes during training for the ...Protein energy profiles offer clues about amyloids
...colleagues believe they are creating a statistical method that will help scientists predict which proteins are prone to misfold. "In designing a computer model for protein folding, you can't take everything into account because there are too many variables," said Vijay Pande, assistant professor chemistry a...New method identifies chromosome changes in malignant cells
...ceton scientists have invented a fast and reliable method for identifying alterations to chromosomes that oc...student Chad Myers and other colleagues invented a method for quickly analyzing an entire genome -- all the genes contained in a cell -- and producing a relia...UF scientists have bionanotechnology recipe to find elusive bacteria
...aid. The secret to the UF team's super-sensitive method is in the sauce: The silica structure they use to bind the antibody-and-dye amalgam together allows each particle to hold thousands of dye molecules, rather than just one, making the fluorescent signal hundreds to thousands of times brighter. Enhanc...Acoustics meeting in San Diego
... ( asutin@artannlabs.com ) will demonstrate a new method for detecting subtle damage in composite materials by using time-reversed acoustics. In this approach, a device sends a short pulse of ultrasound to a material and detects the long echo caused by the initial pulse as it spreads out, as well as multi...... of 32 post-mortem brain samples -- the microarray method can simultaneously measure the level of activity of tens of thousands of genes that are functional in a given tissue. The researchers found that levels of molecules called fibroblast growth factors (FGFs), and two of the receptors that bind to them, ...NHGRI seeks next generation of sequencing technologies
...a exists. In order to reduce labor and costs, this method emphasizes the miniaturization of each step, from sample preparation to DNA sequencing. The platform enables one person to fragment, amplify, sequence and assemble an entire genome, regardless of the genome's size. John Williams, Ph.D., LI-COR Inc.,...Study identifies target for preventing sexual transmission of HIV
... be done before we have an affordable, easy to use method of blocking transmission of HIV through the vaginal membranes," Dr. Lederman said. "But we have taken an important step. Now that we have shown that it is possible to block SHIV transmission through the vagina in macaques and have identified the targ...Purdue chemists give an old laboratory 'bloodhound' a sharper nose
...ray ionization (DESI) - a mouthful of a name for a method that is relatively simple to conceive. "Our device sprays a sample with a stream of high-velocity gas that contains some reactive chemicals," Gologan said. "Just like a strong wind kicks up dust, the gas breaks off a few small particles of the ...Sniffing out the culprits of dust allergies
...ovel combined-library approach for this purpose--a method that enabled simultaneous identification of proteases from complex samples and isolation of protease-specific inhibitors. In this way, Der 1 p was identified as an active cysteine protease in dust mite extracts, and a Der 1 p-specific small-molecule ...S1P1 essential for tumor growth and is blocked by RNA interference
...rs then developed an RNA interference technique, a method that specifically blocks S1P1 expression. They showed that using RNA interference they successfully blocked S1P1 expression in cell culture and that when they injec-tion of the S1P1-specific interfering RNA into tumors in mice, these also showed rep...Babies born after surgery on eggs
...e they contain their own DNA, and Tzeng thinks the method works by replacing those with damaged DNA. In eggs...anulosa cells have around five copies. Because the method involves adding a woman's own mitochondria to her eggs, it is likely to be less controversial than u...For inferring the biological tree of life, simple is better
...e Oct. 21 Nature shows that the most widely used method for constructing the tree of life from DNA sequenc...e simulated data. They found that a simple logical method known as maximum parsimony is far more accurate under a wide range of conditions than the state-of-t...New genomic method can identify disease-causing genes
PALO ALTO, Calif. -- A novel computational method to detect disease-causing genes accurately and rap...ay accomplish the task in a single afternoon. The method takes advantage of the block-like patterns of genomic variation in selected mouse strains, as illust...GENEPI: a tool to refine and fine-tune radiotherapy treatment for cancer
... project aims to provide a scientifically rigorous method of predicting both radiotherapy efficacy and side effects based on a wide range of genetic, physical and other patient-related factors. It will lead to the establishment of the only pan-European database on radiation-related morbidity and will be ope...Stimulating nerve cells with laser precision
... by the brain considerably closer by discovering a method that uses laser light, rather than electricity, to...er precision, accuracy and effectiveness." The method was developed by Mahadevan-Jansen; her husband Duco Jansen, associate professor of biomedical engine...Munching microbes could cleanse arsenic-contaminated groundwater
...inated groundwater might be a simple but effective method to sequester the arsenic, Kirk said. "The bacteria are already present, so all you have to do is stimulate them." Sulfate salts, he said, are inexpensive, readily soluble and easily obtained. In addition to Bethke and Kirk, the team included UI geo...Research to explore revolutionary gene sequencing: Threading the molecular needle
...lems of individual patients. A radical new method of DNA sequencing currently being explored by Stua...g. If Lindsay's proposed sequencing method can be made towork, it would be remarkably faster and more accurate than current sequencing technolo...Economics and ecology combine at UGA in NSF-funded study of evolutionary game theory
... "For instance, it would be the preferred economic method for studying how two firms might compete with one another in the marketplace," said Keenan. "There is, however, a newer branch, called evolutionary game theory, which is useful in biology." "Our work will apply game theory to the conflict between th...