Interaction of just 2 genes governs coloration patterns in mice
...nes the patterns of fur coloration that camouflage mice against their background, protecting them from man...hat display lighter bellies and darker backs, from mice to tuxedo cats to German Shepherds." Hoekstra and co-authors Cynthia C. Steiner at UCSD and Jesse ...Newly created cancer stem cells could aid breast cancer research
...injected with just 100 of these transformed cells, mice developed tumors that metastasized (spread to dist... the same tumor-initiating genes, injected them in mice and watched the result. The cells that were grown in the new culture medium were 10,000 times more p...High blood pressure, low energy -- a recipe for heart failure
...l Metabolism, Kelly and his colleagues report that mice born without any ERR alpha developed symptoms of h...o pump against high pressure. The hearts of normal mice took that pressure overload in stride and stayed healthy. Those contrasting outcomes suggest that he...Abnormal fat metabolism underlies heart problems in diabetic patients
...lipid) composition of heart tissue from laboratory mice with diabetes. They have found that heart cells of diabetic mice lose an important lipid from cellular components that generate energy for the heart, and their lates...OHSU turns mouse into factory for human liver cells
...n the last decade, scientists have studied whether mice could be genetically engineered and bred to grow h...esults since 2004 showed it could be done, but the mice were difficult to breed, the time window for transplanting human liver cells into the mice was narro...Gilbert Foundation and American Fed for Aging Research award grants on Alzheimer's disease
... Aviv University: "Hippocampus characterization of mice over-expressing APP and APOE3/4 using multi-dimensional MRI" Dr. Assaf will study the role that the biochemical substances APP a precursor protein to amyloid-, the gene apoE4, and environmental factors play in brain plasticity, degeneration and cogn...Antioxidant overload may underlie a heritable human disease
... fact, balance is the key. The researchers show in mice that an overload of natural antioxidants can actua.... In the current study, the researchers examined mice carrying a human mutation earlier linked to so-called protein aggregation skeletal myopathies and ca...Research shows skeleton to be endocrine organ
...ported by the Columbia research, which showed that mice with high levels of osteocalcin activity were prev...ic even when they ate a high fat diet. Analysis of mice lacking the osteocalcin protein showed that they had type 2 diabetes, increased fat mass, a decrease...New molecular regulators of hyperthyroidism and goiter
...urnal of Clinical Investigation, indicates that in mice Gq/G11-mediated signaling has an essential role in...m the University of Heidelberg, Germany, generated mice lacking the alpha-subunits of both Gq and G11 only in cells of the thyroid gland. These mice had red...JCI table of contents: Aug. 9, 2007
...urnal of Clinical Investigation, indicates that in mice Gq/G11-mediated signaling has an essential role in...m the University of Heidelberg, Germany, generated mice lacking the alpha-subunits of both Gq and G11 only in cells of the thyroid gland. These mice had red...Cardio exercise benefits in male vs. female hearts
...tudy examining chronic exercise in male and female mice finds that moderate long-term exercise provokes a ...se (using a running wheel) of both male and female mice during the course of 5 weeks. They also held a control group of mice under the same conditions, but ...Inflammation may cause preterm labor and fetal deaths
...nce of dead or living bacteria in the placentas of mice can be blocked, the number of preterm deaths will ... In the present study, the researchers found that mice deficient in TLR4 lacked the necro-inflammatory response to bacteria and produced healthy pups. Thi...News tips from the Journal of Neuroscience
...tant variants in chromaffin cells from Munc18 null mice and used uncaging of calcium to trigger release of primed vesicles. Expression of the NV mutation that prevents binding to closed syntaxin1 reduced vesicle docking. However, Munc18-1 NV rescued release, albeit to a lesser extent than wild type. Thus,...Preclinical study links gene to brain aneurysm formation
...ar Research. The UC-led team analyzed 30 female mice bred to suppress (knock out) one of three genes and molecular pathways associated with vascular disease: inducible nitric oxide synthase (NOS-2), endothelial nitric oxide synthase (NOS-3) or the plasminogen activator inhibitor (PAI-1). To determin...High-intensity ultrasound may launch attack on cancer, wherever it lurks
...ighting white blood cells. If the effect seen in mice holds true in human patients, such a treatment cou... called danger signals. The researchers found in mice with colon cancer that mechanical HIFU delivered to the animals tumors sparked an immune response tw...UCF research links proteins, stem cells and potential Alzheimer's treatment
...ts very exciting, Sugaya said. If our success with mice can translate into the human brain, it could give ...ons. The research team treated Alzheimers-model mice producing human APP with phenserine, which is known to reduce the amount of APP in the brain. The AP...Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
...that the embryos therefore are anemic, compared to mice missing KLF2 or EKLF alone. This likely means that EKLF and KLF2, which are related transcription factors, regulate overlapping groups of genes in developing red blood cells. In the absence of both factors, they cannot compensate for each other, c...UF, French scientists seek test to detect gene doping in athletes
... the first reports of muscle-boosting therapies in mice were published by University of Pennsylvania researchers. Since then, several potential targets of gene doping have emerged, including the gene for erythropoietin, or EPO. A bioengineered version of the hormone, currently on the market, increases ...Disabling a sensory organ prompts female mice to act like male mice
...g the sensory organ that detects the chemical cues mice use to attract mates, a team of Howard Hughes Medi...l Institute (HHMI) researchers has prompted female mice to behave like male mice in the throes of courtship. The finding, reported August 5, 2007, in the ...