Global heartbeat control suggests therapy for beating heart failure
...of well-defined energy pathways." Further study of mice lacking ERR provided evidence that the receptor plays an important role in the cardiac energy-sensing machinery. Among the genes targeted by the receptors, the researchers uncovered several that had been linked previously to cardiomyopathies, a fin...Molecule that destroys bone also protects it, new research shows
... Gaffen and colleagues conducted the research in mice bred to have no receptors for IL-17. Other researchers had shown previously, using rats and mice as animal models, that blocking the receptor for IL-17 could be an effective therapy for RA and poss...Fat screen delivers plant-derived chemical with antidiabetic effects
...ingredient found in some plants fights diabetes in mice without some of the side effects attributed to oth.... Further study of harmine's effects in diabetic mice found that the chemical increases insulin sensitivity in a manner similar to, though more roundabout...Newborn neurons like to hang with the 'in' crowd
...o the existing network of brain cells, at least in mice living in bare standard cages. Providing the mice with a stimulating, enriched environmentlarge cages filled with running wheels, colored tunnels and ...2 UCSD physician-scientists named to Association of American Physicians
...shaw-Boris focus is on the genetic manipulation of mice to generate a number of mouse models which replicate human diseases. He has used the insights obtained from these animals to define novel pathways for disease pathogenesis and therapeutics. ...Nitric oxide: Key to cardiovascular and pulmonary function and drug effectiveness
...found that when SNO compounds were administered to mice they could prevent the receptors from being "turned off" by the drugs. The researchers said these findings, if confirmed in humans, open up new avenues for the development of non-desensitizing drugs not only for heart failure and asthma but also fo...Story ideas from the Journal of Lipid Research
...tabolism of fatty acids. The scientists found that mice fed diets high in saturated and monounsaturated fa... showed an increase in acyl-coenzyme A compared to mice fed a diet enriched in polyunsaturated fat. These results suggest that polyunsaturated fat is a more...Vaccine prevents prion disease in mice
BOSTON An oral vaccine can prevent mice from developing a brain disease similar to mad cow...dified strain of Salmonella. For the study, the mice were orally vaccinated with a safe, attenuated Salmonella strain, which expressed the prion protein....Scientists identify new strategy for preventing acute and chronic brain disease
...Science, demonstrate that when tau is removed from mice genetically engineered to simulate Alzheimer's dis...e a normal lifespan. Reducing tau levels also made mice more resistant to epileptic seizures. "This is the most striking therapeutic effect I have ever se...Vitamin extends life in yeast, Dartmouth Medical School researchers find
...rie reduction can extend life. Dieting or fasting mice live longer and lowering the glucose that yeast gr...tor is the red wine compound resveratrol. Overfed mice on high dose resveratrol have healthier livers, better endurance and possibly longer lifespan. Whil...Keeping the immune system from starting a 'food fight'
...urrounding the internal organs of STAMP2-deficient mice became inflamed, and the animals developed spontan...ss of STAMP2 exacerbated the metabolic symptoms of mice with a genetic predisposition to obesity due to other factors. When food enters the system, STAMP2...Master regulatory gene of epithelial stem cells identified
...wn tumor-suppressing p53 gene. Without p63, mutant mice run out of the regenerative epithelial stem cells....e cells in these tissues. "With the p63-lacking mice you get normal commitment and differentiation," says McKeon. "The defect is simply running out of st...Study of damaged gene gives insight into causes of mental illness
...their findings, experts looked at the behaviour of mice with two types of damage in the gene. The results suggest that one responded better to antipsychotics, used to treat schizophrenia while the other responded better to anti-depressants, used to treat mood disorders. Prof David Porteous, Chair of Hum...J&JPRD discovery may lead to new treatments for chronic sensitivity, pain caused by cold
...lying cold sensitivity. Scientists used a line of mice that lacked a critical ion channel receptor called...d menthol receptor 1. Then, they tested how these mice reacted to cold stimuli, and found that not having these receptors reduced their adverse reactions t...Gene malfunctions cause schizophrenia, depression symptoms in mice
...ms of those disorders. They said their findings in mice offer a possible animal model for developing treat...ionally, these symptoms could be alleviated in the mice by antipsychotic drugs. Similarly, the other mutant mouse strain showed behaviors that reflected d...'Insulator' helps silence genes in dormant herpes virus
...searchers now plan to study the HSV-1 insulator in mice to see how the mechanism works to block the communication of gene-activating elements such as enhancers and promoters. The group is also working to identify any additional proteins that may play a role in establishing the insulator. Knowing what ge...Salk researchers discover first gene that specifically links calorie restriction to longevity
La Jolla, CA In studies going back to the 1930s, mice and many other species subsisting on a severely ca...lated neurodegeneration in laboratory animals from mice to monkeys. Although some people are already imposing this strict regimen upon themselves, it is too...Scripps research team sheds light on long-sought cold sensation gene
...the hypothesis, the group observed the behavior of mice genetically altered to lack the gene in response t... where they could choose between two temperatures, mice without TRPM8 showed essentially no preference in the temperature range of 18 to 31C, suggesting the...Peramivir protects mice from lethal H5N1 infection
... studied different approaches to treating infected mice according to duration of administration (one day v...cases, the investigators administered peramivir to mice one hour after nasally administering a lethal Vietnam strain of H5N1 influenza virus. The research...... turnover of light subunits (NF-L). They generated mice that conditionally expressed a transgene encoding human NF-L under the control of doxycycline in mice that were either heterozygous (tTA;hNF-L;NF-L +/- ) or deficient (tTA;hNF-L;NF-L +/- ) for endogenou...