Multicenter study nets new lung tumor-suppressor gene
..., the investigators ran a series of experiments in mice with a defective form of a gene called Kras, which drives the formation and growth of lung cancer. They tracked the development of lung cancer in animals with mutated LKB1 and compared it to the experience of animals with abnormalities in either of t...Defects in critical gene lead to accelerated lung tumor growth
...suppressors commonly mutated in lung cancer. These mice develop cancers of not just one lung cancer subtyp...metastasize, or spread to other organs. Clearly mice with lung cancers harboring LKB1 mutations do much worse than those with other types of cancers; how...A sensory organ, not the brain, differentiates male and female behavior in some mammals
...organ, known as the vomeronasal organ, lead female mice to adopt male behaviors such as mounting and pelvi...authors Tali Kimchi and Jennings Xu studied female mice mutant in TRPC2, an ion channel whose absence disables the vomeronasal organ, which works along with...Discovery of new protein could provide new understanding of male fertility
.... They measured the expression levels of UBE1L2 in mice and found that the protein was expressed about five times more in the testis than other organs. Again, this was totally unexpected, Goettrup says. Unlike the first E1, UBE1L2 might have a specialized role in tissues and in particular in the testis....Discredited Korean embryonic stem cells' true origins revealed
...mmune system. The team recently demonstrated in mice a feasible technique for generating parthenogenetic embryonic stem cells that were genetically matched to the egg donor at the genes that control tissue typing, and are attempting to create similar cells from humans. (see http://www.childrenshospita...New strategy for treating allergic disorders
... produce the ovalbumin (OVA) protein. Tested on mice Inge L. Huibregtse (AMC) and Veerle Snoeck (VIB) evaluated the use of OVA-secreting bacteria on mice that were allergic to ovalbumin. By administering OVA-secreting bacteria, which deliver ovalbumin to...Altering a protein makes mice less fearful
...ear behavior in lab animals, making normally timid mice relatively fearless. The findings might provide us...the ASIC1a protein alters innate fear reactions in mice and suggests that this protein may be a critical component of the brain systems that underlie innate...COX-2 inhibitors delay pancreatic cancer precursors in mice
...(stage I or II) begin to appear in the pancreas of mice at one month. Starting at six months, high-grade P... 15 months, Dr. Eibl says the majority of KrasG12D mice will develop pancreatic tumors. The UCLA researchers divided the mice into two groups one set rec......nfect laboratory workers but remains infectious in mice and other animals. The form is also used in animal anthrax vaccines. The scientists were able to profile all the significant genetic activities in the microbe at several points in time as it invaded the macrophage, germinated, killed its host, and...Handicapping tuberculosis may be the way to a better vaccine
...sands of immune cells from the genetically-altered mice into normal mice, which they then infected with th...g a memory response, proliferated much more in the mice that had been infected with the apoptosis-inducing strain. This means that the immune system was abl...Developing a more effective vaccine for tuberculosis
... type, the macrophage. Importantly, vaccination of mice and guinea pigs with M. Tuberculosis lacking SecA2 provided increased protection against infection with M. Tuberculosis than did vaccination with M. bovis BCG. These data led the authors to suggest that this approach, in combination with others curre...JCI table of contents: August 1, 2007
... type, the macrophage. Importantly, vaccination of mice and guinea pigs with M. Tuberculosis lacking SecA2...w that the induction of high levels of oxidants in mice lacking Foxo3 caused them to die rapidly. Red blood cells from these mice expressed fewer proteins a...U-M researchers find family of 'on switches' that cause prostate cancer
...er to develop. By testing these gene fusions in mice and in cell cultures, the researchers showed that the fusions are what cause prostate cancer to develop. But its not just one set of genes that fuse. The researchers found that any one of several in a family of genes can become scrambled and fuse. Re...Cost-effective method for gene silencing is featured in Cold Spring Harbor Protocols
...t describes how to culture thymus cells from fetal mice ( http://www.cshprotocols.org/cgi/content/full/2007/16/pdb.prot4808 ). The thymus is the organ where T-cellsa principal component of the immune system in vertebratesproceed through a strictly coordinated maturation process before being released into ...MGH researchers confirm that bone marrow restores fertility in female mice
...al Hospital (MGH) researchers confirms that female mice that receive bone marrow transplantation after fer... that donor marrow can restore fertility in female mice through an as-yet unidentified mechanism. While donor-derived egg cells or oocytes were observed in...Huntington's disease study shows animal models on target
...low for comparisons between the gene expression in mice and in human patients. Interestingly, results of different testing strategies converged to show that several available models accurately recapitulate the molecular changes observed in human HD, explains Luthi-Carter. It underlines the suitability of...Negative effects of plastic's additive blocked by nutrient supplements
...n of animals known as agouti mice. Normally, these mice tend to be slender and brown. While past epigeneti...rn with a yellow coat. Previous studies with these mice have shown that yellow agouti mice are at a much greater risk for diabetes, obesity and cancer. Th...Insulin grown in plants relieves diabetes in mice; UCF study holds promise for humans
...freeze-dried plant cells to five-week-old diabetic mice as a powder for eight weeks. By the end of the study, the diabetic mice had normal blood and urine sugar levels, and their cells were producing normal levels of insulin. ...Caffeine and exercise can team up to prevent skin cancer
...ontrol, didnt run and didnt caffeinate. All of the mice were exposed to lamps that generated UVB radiation...xercisers showed a 120 percent increase, while the mice that were both drinking and exercising showed a nearly 400 percent increase. The most dramatic an...Strains of laboratory mice more varied than previously thought
...tion in the most widely used strains of laboratory mice is vastly greater than previously thought. Wher... staff scientist. Weve established that laboratory mice are derived almost entirely from a single subspecies, not three as previously believed. The Jacks...