St. Jude study solves mystery of mammalian ears
... the team developed a line of genetically modified mice that carried only mutant prestin in their outer hair cells. The researchers then tested the animals responses to sound. Results of the studies showed no alteration in hearing, which suggested that it did not matter whether the outer hair cells con...A friendly foe -- Bacteria residing in the gut boost immune response to tumors
... causing disease. Restifo and colleagues subjected mice genetically deficient in lymphocytes to TBI and found that, like TBI-treated mice with intact lymphocytes, TBI was still able to positively augment the function of adoptively transfe...JCI table of contents -- July 26, 2007
... causing disease. Restifo and colleagues subjected mice genetically deficient in lymphocytes to TBI and found that, like TBI-treated mice with intact lymphocytes, TBI was still able to positively augment the function of adoptively transfe......olleagues, have now developed genetically modified mice that carry a promising candidate reporter named ferritin, which could circumvent these problems. Ferritin works by sequestering iron from cells. When it is overexpressed, iron uptake increases, causing signal changes in the surrounding environment t...U-M researchers identify gene involved in breast cancer
...earchers found in studying mice, 90 percent of the mice spontaneously developed cancerous tumors. The rese... autoimmune disease, when they noticed that female mice with one copy of the mutated form of the gene were developing breast cancer. Moreover, the tumors ex...U-M team identifies gene that regulates blood-forming fetal stem cells
...atopoietic stem cells. In follow-up experiments, mice were irradiated to destroy their blood-forming ste...ntaining the Sox17 gene and others lacking it. The mice that received Sox17-bearing cells were able to regenerate their blood systems. Those that received c...MicroRNA works with Ago2 protein to regulate blood cell development
...ment of blood cells. In the bone marrow of adult mice where their blood stem cells reside OCarroll con... anemia and the enlarged spleen in both groups of mice were cured, suggesting that this feature of Ago2 makes only a minor contribution to its biological f...Air pollution link to clogged arteries
...hways. To confirm these findings, the team exposed mice with high cholesterol levels to the pollutant diesel particles, and saw some of the same gene modules upregulated. The American Cancer Society has reported a six percent increase in cardiopulmonary deaths for every 10 g/m3 rise in particulates. Exa...UCLA study links air pollution to clogged arteries
...se findings in living cells, the UCLA team exposed mice with high cholesterol to the diesel particles and saw activation of some of the same gene groups in the animals tissue. Exactly how air pollutants cause cardiovascular injury is poorly understood, Nel said. But we do know that these particles are ...Females more prone to brain damage from alcohol abuse
...ologist, PVAMC Research Service, found that female mice are more susceptible to neurotoxic effects of alco...ntify gene expression differences between lines of mice that are genetically selected for severe alcohol withdrawal compared with mice that are resistant to...Scratch no more: Gene for itch sensation discovered
...ed by Zhou-Feng Chen, Ph.D., found that laboratory mice that lacked this gene scratched much less than the... signals to the brain. So they began to study some mice that were missing the GRPR gene to find out how they were different from normal mice. "The research...Discoverer of Sly Syndrome finds way of delivering medicine to fight rare genetic disorder
...ions of the missing enzyme into the brains of baby mice reached their target, but similar injections into mature mice did not. As the mice grew older, the transporter that brought the enzyme past the protective blood-b...News tips from the Journal of Neuroscience
...l, axonal injury. The authors generated transgenic mice that expressed ATF3 constitutively in DRG neurons. After sciatic nerve crush, ATF3 transgenic mice displayed early nerve regeneration similar to wild-type (WT) mice after a preconditioning lesion. Pr...Drug protects brain cells in Huntington's disease model, researchers find
...ntingtons disease prevents death of brain cells in mice genetically engineered to mimic the hereditary con...urrent study, the UT Southwestern researchers used mice that were genetically engineered to carry the mutant human gene for Huntingtons, causing symptoms an...Faster-acting antidepressants closer to becoming a reality
...MH study in humans had shown, but the new study in mice shows that this is an intermediate step. It turns...epression-like behaviors in mice; for example, the mice gave up after being forced to engage in hopeless tasks, such as prolonged swimming. A dose of ketam...Effects of aging in stem cells
...rom young (aged 2 months) and old (aged 21 months) mice and then transplanted either young or old cells into mice whose bone marrow cells had been destroyed by radiation. The young and old HSCs gave rise to new mar......actating mammary gland. They generated a strain of mice that, as adults, lacked PPAR only in hematopoietic and endothelial cells. When these PPAR-deficient animals became mothers, they appeared normal, but the milk they produced most certainly was not. "We were delighted and surprised by the discovery ...'Preconditioning' helps protect brain's blood vessels from stroke
...hanisms involved in this process, our new study in mice demonstrates that preconditioning also shields the...rain whenever a more toxic event occurs." Normal mice given an inflammatory toxin called lipopolysaccharide (LPS) 24 hours before an induced stroke -- the...New clue into how diet and exercise enhance longevity
...hat knocking out both copies of the Irs2 gene in mice reduces brain growth and produces diabetes due to ...cked out only one copy of the gene, they found the mice lived 18 percent longer than normal mice. Because reducing insulin-like signaling in the neurons of......cterial infection. These authors orally infected mice with the bacterial pathogen Campylobacter jejuni (... be detected in the organs of the vast majority of mice lacking Muc1, but never in mice with intact Muc1. Although this organism was able to enter the gastr...