JCI table of contents: June 21, 2007
...er, Yong Chen and colleagues studied Pten-knockout mice (which are predisposed to develop prostate tumors) and the effects on these mice of diets with defined levels of specific polyunsaturated fatty acids. The authors found that a nutri...Researchers pit novel version of common virus against cancer
...m said. Investigators are testing the concept in mice and in the laboratory with human pancreatic cancer cells. Pancreatic cancer was selected because of its poor prognosis and current lack of effective therapies. Although it accounts for only about two percent of new cancer cases diagnosed annually in ...A faster way to recover from chemotherapy and marrow transplant
... lab, production of blood stem cells increased. In mice that underwent bone marrow transplant, treatment with dmPGE2 led to enhanced blood-stem-cell formation, and the stem cells remained present in the marrow more than six months after transplantation, indicating long-term engraftment. The fact that we ...Tips from the Journals of the American Society for Microbiology
... through a patch applied to the skin that protects mice from C. difficile infection. They report their fi... responses to both toxins and blood from immunized mice was capable of neutralizing C. difficile toxin A in a cell culture test. Our results suggest that...News tips from the Journal of Neuroscience
...ining GLT-1 encoded green fluorescent protein. The mice expressed endogenous transporters, and the fluores...tions were altered in the ophthalmic projection of mice lacking Slit2/Slit3 or Robo1/Robo2. Although branches below the eye appeared normal, the arbor above...Fever after smallpox vaccination tied to individual genetic variations
...so reduced fever risk. Interestingly, studies in mice have shown that immune system molecules produced by the IL-1 and IL-18 genes are linked to tissue damage in viral myocarditis, raising the question of whether a more severe complication of smallpox vaccination might be associated with variations in t...Promising protein may prevent eye damage in premature babies
...g, eye and other body tissues. But in studies of mice and of human cells in cultures, scientists from th...chers infused IGFBP-3 into one eye of each of nine mice before placing the animals into a high-oxygen chamber for five days. When scientists compared vascul...American Chemical Society's Weekly PressPac -- June 13, 2007
... The researchers genetically engineered laboratory mice to produce milk enriched in pig LF, and studied the growth of 10 generations of mice pups fed on the milk. Mice fed LF-enriched milk grew 10-15 per cent faster than those fed on ordinar......st amount of the total genome, he adds. Because mice are used to study human disease, we want to know t...eces of two chromosomes, making it easier to breed mice with human cancers. Such mice are needed to develop new treatments. Vast, Non-Gene Stretches of...Hot on the TRAIL of controlling inflammation in bacterial meningitis
...ospinal fluid bathing the brain and spinal cord of mice lacking TRAIL. They found that these animals suffe...rTRAIL). Importantly, the application of rTRAIL to mice with intact TRAIL and meningitis also decreased inflammation and neuronal cell death. Finally, the a...Research finds that circadian rhythms dominate all life functions
.... For example, while gene expression oscillates in mice exposed to a constant state of dim light or darkness, the groups of genes that typically oscillate together -- such as genes responsible for the function of an organ or a specific tissue -- are chaotic under this state and don't function as a group. ...Pre-cancerous blood diseases can be products of their environment
...aid. Purtons team found in an earlier study that mice lacking the retinoic acid receptor RAR one of thre...e bone marrow deficiency. Bone marrow from healthy mice transplanted into mice with the RAR-deficient microenvironment rapidly developed the blood disease, ...Cytokine resistance contributes to pathology of type 2 diabetes
...n that macrophages in diabetic and obese (diabese) mice secrete more pro-inflammatory and less anti-inflam...o showed that the loss of IL-4 function in diabese mice caused chronic over-expression of an important suppressor of cytokine signaling (SOCS) protein. This...JCI table of contents: June 14, 2007
...ospinal fluid bathing the brain and spinal cord of mice lacking TRAIL. They found that these animals suffe...rTRAIL). Importantly, the application of rTRAIL to mice with intact TRAIL and meningitis also decreased inflammation and neuronal cell death. Finally, the a...A possible mechanistic link between stress and the development of Alzheimer tangles
La Jolla, CA -- Subjecting mice to repeated emotional stress, the kind we experien...hat extreme physiological stress, such as plunging mice into ice water or starving them for three days, can induce tau phosphorylation. But what we wanted t...LIAI researchers identify a potential role for retinoic acid in autoimmune and inflammatory diseases
...th retinoic acid. In one model, they injected the mice with retinoic acid, essentially giving them more of the substance than they would have through normal body processes. This suppressed the formation of pro-inflammatory T cells in the intestines of the mice, demonstrating that increases in retinoic a...Bacteria ferry nanoparticles into cells for early diagnosis, treatment
.... The researchers also tested their method on live mice and showed how the technique could be used to deliver specific genes to various organs, including the liver and kidneys. "The cells in the organs receiving the bacteria with nanoparticles made the intended therapeutic proteins and emitted a light s...Herpes virus hijacks DNA repair process
...ctions with other molecules, researchers turned to mice lacking the genes for ATM and H2AX, the damage res... by infection. When they infected cells from these mice with murine herpes virus, its ability to reproduce was again curtailed. How DNA damage response bene...5.9 million award gives UK aging research a new lease on life
...d Gems, a co-recipient of the award. "For example, mice remain youthful for longer and have glossy fur with slowed appearance of grey hair. Their eyes are unclouded by cataracts, and they are more active, both physically and sexually." The researchers hope to explore how their findings in the animal mod......e. Help for premature infants Interestingly, mice and humans also have a single "Wurst" gene. "We as... "We will then try out any promising candidates on mice with RDS as well as on human lung cell cultures." Another area that interests the researchers is a...