Other highlights in JNCI, June 12
...ns. Additionally, deguelin reduced tumor growth in mice without any detectable toxic side effects. Extensive and complete chronic toxicity testing in clinical trials is warranted before the further development of deguelin as an anticancer therapeutic agent, the authors write. Contact: Laura Sussman,...News tips from the Journal of Neuroscience
... Blanz et al. found a quite different phenotype in mice that were either heterozygous or deficient in Clcn2 . This widely expressed chloride channel is activated by cell swelling, lowered pH, and voltage. Mice lacking Clcn2 showed spongiform vacuolation of the central white matter, basically a picture ...NIH awards nearly $21 million to fund cutting-edge research equipment
...ariety of animal sizes and species from transgenic mice to non-human primates, spanning multiple disciplines such as oncology, aging, and neurological and psychiatric disorders. University of Washington (Seattle, Wash.) $1,040,735. A pulsed electron paramagnetic resonance/X-band electron nuclear d......hat with motherhood, the auditory cortex in female mice responds more quickly and robustly to the ultrason...these two groups of female mice: neurons in mother mice respond more quickly and robustly. The authors further establish that this difference in neural r......the researchers used a line of genetically altered mice to pinpoint how the dentate gyrus contributes to t...ved in identifying new and old spaces. Whilst the mice behaved normally in most situations, they became confused when required to discriminate between diff...Menthol receptor also important in detecting cold temperatures
... react to cooling stimuli, but cells cultured from mice lacking TRPM8 do not. Also, mice engineered without TRPM8 are much less sensitive to cold than mice with TRPM8. TRPM8 does not see...Studies to find better ways to preserve human eggs, ovarian tissue under way
...s will put ovarian tissue preserved both ways into mice to see if it survives and starts making proper connections. The reason for using ovaries is when you have cancer, if you need chemotherapy, you often dont have time to go through stimulation cycles to get oocytes, says Dr. Emmi. You are concentrati...University of Pittsburgh scientists find new contributor to aggressive cancers
...uman cancer cells into immune deficient mice. Some mice received tumor cells in which levels of integrin 7... normal integrin 7 were decreased. Six weeks after mice were implanted with cancer cells in which levels of normal integrin 7 were deficient, they had tumor...Blocking beta1-integrin to treat cancer
...gelika Kren and colleagues investigated transgenic mice with insulinomas tumours of pancreatic beta cells, which metastasize in pancreas lymph nodes. When theauthors blocked beta1-integrin function in these mice, tumour cells started disseminating intolymphatic blood vessels because they were not attached...Reprogrammed fibroblasts identical to embryonic stem cells
...ls, and the Kyoto team was unable to generate live mice from these cells. A team of researchers decided...ich eventually gave rise to live mice. While these mice consisted of both the reprogrammed cells and the natural cells from the original embryo, the fluores...Cancer drug enhances long-term memory
...rning and Memory. Wood and his colleagues placed mice in a chamber and gave them mild electric shocks, s...m memory. A day later, the scientists returned the mice to the chamber to see how well they remembered the place in which they received the shock. Mice trea...Finding protection from tumor growth in unexpected places
...eth Bernsteins group at Emory University generated mice (ACE 10/10) that express ACE only in macrophages. ...en injected with aggressive melanoma cells, normal mice developed large melanoma tumors whereas ACE 10/10 mice developed only very small tumors. The resista...News tips from the Journal of Neuroscience
...xin-B1 ( Plxnb1 -/- ) developed normally, whereas mice deficient in Plexin-B2 ( Plxnb2 -/- ) displayed s...cumulate and form active dimers with HIF-1. Mutant mice with conditional deletion of HIF-1 in forebrain neurons fared worse than wild-type (WT) mice after f...Uncovering the molecular basis of obesity
...ones are made with the result that only rarely the mice go looking for food even if they have been starvin...cific hunger signals from the body without it the mice do not feel hunger. Bsx is conserved across species and very likely plays a similar role in contr...Stanford researchers find stem cells in colorectal tumors
...lecular diagnostics and therapeutics, test them in mice that carry the cancer stem cells and, hopefully, in a few years begin to test them in our patients," Weissman said. The colorectal cancer stem cells highlight the importance of a protein that is a familiar face to this group of cancer researchers. ...New insights into the neural basis of anxiety
...eat while other times nothing might happen. Normal mice show less fear towards such ambiguous cues than to...e wiring of the brain that affect the behaviour of mice later on in life. "In humans serotonin signalling has been implicated in disorders including depre...Gene therapy delivery of nerve growth factors reverses erectile dysfunction in animal model
...rve growth factor closely related to GDNF. Control mice received only the virus without the GDNF or neurte...h rats treated with the control virus or untreated mice with ED. Rats treated with HSV-neurturin also exhibited significant recovery of ICP and AP compared ...JCI table of contents -- June 1, 2007
...hesis. In the current study the authors found that mice carrying one of the most common mutations observed...ascular remodeling in heparin cofactor IIdeficient mice AUTHOR CONTACT: Toshio Matsumoto The University of Tokushima Graduate School of Health Bioscie...Cigarette smoke alters DNA in sperm, genetic damage could pass to offspring
...kes. Canadian researchers have demonstrated in mice that smoking can cause changes in the DNA sequence...y, studied the spermatogonial stem cells of mature mice that had been exposed to cigarette smoke for either six or 12 weeks to look for alterations in a spe...Enzyme delivered in smaller package protects cells from radiation damage
...nganese superoxide dismutase (MnSOD) could protect mice from whole body irradiation, and in preparation for a potential clinical trial of systemic MnSOD in humans, the University of Pittsburgh and Stanford researchers, led by Joel S. Greenberger, M.D., professor and chair of the department of radiation on...