Gene therapy offers new hope for treatment of peripheral neuropathy
...leviation of the pain response in GlyR-HSV-treated mice was reversed by the subsequent addition of low concentrations of strychnine, a strong GlyR-specific inhibitor, or antagonist. According to Dr. Glorioso, these findings suggest that HSV-directed expression of GlyR in peripheral neurons and subseque...Existence of muscle-building stem cells points to regenerative therapies for muscular disease
... of the "satellite stem cells" into the muscles of mice successfully replenished the animals regenerative reservoir of cells. "Weve found that there are two types of satellite cell90% that are already committed to becoming muscle and another 10% with characteristics normally attributed to stem cells," R...Evolution of animal personalities
...the animal kingdom. Animals as diverse as spiders, mice and squids appear to have personalities. Personality differences have been described in more than 60 species, including primates, rodents, birds, fish, insects and mollusks. New work by Max Wolf (University of Groningen; currently at the Santa Fe In...Molecular motors may speed nutrient processing
... microvillus. Brush borders isolated from knockout mice lacking the myosin-1a gene shed membrane at only five percent of the level of brush borders from wild-type animals. The investigators are working now to understand why intestinal cells might launch vesicles from their microvilli. They know from ongoi...Natural compound and exercise boost memory in mice
...ished research. This effect increased further when mice also exercised regularly. "This finding is an im...elated to aging. Van Praag and her team compared mice fed a typical diet with those fed a diet supplemented with epicatechin. Half the mice in each group ...ACS News Service Weekly PressPac -- May 23, 2007
...hotgun lipidomics" to show that hearts of diabetic mice lose large amounts of cardiolipin (CL), fatty materials essential for the heart's production of the energy needed for normal contraction. The changes, which involved a loss of CL followed by changes in the remaining CL, occurred as early as 5 days af...Avian influenza survivors' antibodies effective at neutralising H5N1 strain
...irus are effective at both preventing infection in mice and neutralising the virus in those already infect...at the antibodies provided significant immunity to mice that were subsequently infected with the Vietnam strain of H5N1. This reduced significantly the amou...New mouse model closely mimics human cancers
... Ronald A. DePinho, MD, of Dana-Farber has created mice that form tumors that are more genetically complex...d the patterns of these chromosomal changes in the mice with patterns observed in more than 400 human tumor specimens, including melanoma, lung, colon, and ...Story ideas from the Journal of Biological Chemistry
...curcumin boosts the immune system of tumor-bearing mice by restoring key immune cells called CD4 and CD8 T cells. The scientists also showed that curcumin increases the production of proteins that cause immune cells to proliferate and reduces the production of proteins that destroy immune cells. Artic...JCI table of contents: May 24, 2007
...opment of insulin resistance in the livers of lean mice fed a normal diet, as well as impaired insulin sig...osclerosis, and inflammation. Recently, studies in mice have shown that resistin is present in the mouse hypothalamus and that it is capable of activating s...A nurse makes the decision on who will live
...lteration in the animals studied results in female mice whose thymocytes undergo positive selection, exclusively, while all thymocytes in male mice are negatively selected. If thymic nurse cells only internalize thymocytes that will be killed and ......esting system which, for the first time, mimics in mice the way malaria infects humans. When injected into...causes malaria in people. And the immune system of mice shows a different response to humans when it comes into contact with the parasite. This meant that...Fragile X syndrome -- A stimulating environment restores neuronal function in mice
...ogy of Fragile X syndrome, the researchers studied mice in which the same gene that causes the disease in ...ientists analysis revealed that the neurons in the mice showed reduction of a particular form of a process called "long-term potentiation" that is central t...Tiny genes may increase cancer susceptibility, Jefferson scientists find
...an to examine miRNA expression levels among inbred mice strains. "Could the level of a particular miRNA affect the expression of other genes and regulate the stability of the RNA transcript" she asks. "Having a slightly lower level of a particular miRNA could make a person more susceptible to a particular...Stem cells may look malignant, not act it
...borhood of cancer." The researchers then studied mice who underwent bone marrow transplant and developed the same cancers as the women. When they viewed the cancerous tissues under the microscope, they found marrow cells shared outward features of the cancer cells. Cogle said research conducted elsewh...News tips from the Journal of Neuroscience
...atal day 5 and, unlike other TSC mouse models, the mice developed spontaneous seizures. Pathological featu...n presumably resulted from axonal dysfunction. The mice had a wasting syndrome and died at 35 weeks of age. These observations support loss of neuronal TSC...UVa researcher studying disease that cripples newborns
...eats to the DNA of a gene that made the muscles in mice glow green under a microscope. This enabled easy o...so devised an on switch that activated DM when the mice drank water containing the antibiotic doxycycline. Within a few weeks, the doxycycline caused the mi...Immune antibodies penetrate neurons to clear Alzheimer's-linked amyloid
...ey relied on the development of special transgenic mice bred to closely approximate the progress of human ...earchers exposed amyloid-filled neurons from these mice to immune antibodies similar to those used in clinical trials. They then examined changes in these c...Mice, men make livers differently
CAMBRIDGE, Mass. -- Scientists often study mice as a model for human biology and disease, because ...latory proteins function in very different ways in mice and humans. "Evolution has discovered several different ways to make a liver from the same buildi...New data on the probiotic strain Bifantis shows anti-inflammatory properties
...in autoimmune diseases. In the second study, mice were fed Bifantis and then exposed to Salmonella, a common bacteria associated with a form of food poisoning. Animals that received Bifantis showed dramatically increased numbers of certain immune cells that control the immune systems response to ha...