How does day length affect aggression in mice? It's in the genes
... has totally opposite effects on behavior in these mice depending only on how much light they got each day... that influences aggression." In one study, male mice were castrated to stop production of testosterone. They then were fitted with implants that controll...Caspase-14 protects our skin against UVB and dehydration
...clercq and Peter Vandenabeele, developed knock-out mice that could no longer produce the protein. The shiny and lichenified skin of mice without caspase-14 is a sign that the composition of the skins epidermis has been altered. The lack ...UF researchers awaken vision cells in blind mice
... researchers used gene therapy to restore sight in mice with a form of hereditary blindness, a finding tha...ed a harmless virus to deliver corrective genes to mice with a genetic impairment that robs them of vision. The discovery shows that it is possible to tar...Repair of DNA by Brca2 gene prevents medulloblastoma
...e brain developed its normal size, but most of the mice developed medulloblastoma. The study also gave ...n the current study, the St. Jude team showed that mice lacking Brca2 had neurologic defects similar to those of humans with Fanconi anemia who carry the mu...Clock gene plays role in weight gain, study finds
...in regulating metabolism. Their finding shows that mice lacking the gene Nocturnin, which is regulated by ...and dieting. Green and her colleagues used regular mice and genetically altered mice in which the Nocturnin gene was knocked out. The Nocturnin-deficient mi...Antibody-based therapies effective at controlling malaria
...parasites transgenic for P. falciparum antigens in mice and humans. An in vivo mouse model has significant...t to reproduce. These novel human reagents cured mice of an otherwise lethal malaria infection, and protection was crucially dependent on human antibody r...Lipoic acid explored as anti-aging compound
... to is lipoic acid. "Our studies have shown that mice supplemented with lipoic acid have a cognitive ability, behavior, and genetic expression of almost 100 detoxification and antioxidant genes that are comparable to that of young animals," Hagen said. "They aren't just living longer, they are living be...Herpes infection may be symbiotic, help beat back some bacteria
... Virgin and his colleagues to test herpes-infected mice with exposure to the bacteria Yersinia pestis, whi...vous system. Many aspects of Listeria infection in mice are also similar to those that occur in humans infected with tuberculsis. They found that when mice ...First demonstration of new hair follicle generation in an animal model
...f Medicine have found that hair follicles in adult mice regenerate by re-awakening genes once active only in developing embryos. These findings provide unequivocal evidence for the first time that, like other animals such as newts and salamanders, mammals have the power to regenerate. These findings are p...Tips from the Journals of the American Society for Microbiology
...the study researchers compared immune responses of mice preexposed to uninfected mosquito bites followed b...the malaria parasite, Plasmodium spp. and those of mice only exposed to infected mosquitoes. Results showed that in the early stages, mice preexposed to uni...News tips from the Journal of Neuroscience
... Cat-315-positive PN. Sensory deprivation of adult mice had no effect on Cat-315 staining. When whiskers w...anges in dopamine transmission in control C57Bl6/J mice and in PD mice that had been treated with 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Mice...'Nondanger' signal lowers immune reactions
...tep, said Dr. Gallucci, is to test the antibody in mice that have a disease similar to lupus in humans. The study team also expects to test the antibody in animal models of rheumatoid arthritis. In addition, the researchers may investigate a possible role for the antibody as an immunosuppressant, in preve...Other highlights in the May 16 JNCI
...and measured the formation of metastatic tumors in mice injected with the cells. The researchers found that by blocking FLIP expression they increased cell death and reduced metastasis in the mice. "Data from gene expression profiling from other tumor sites also suggest that FLIP overexpression is as...DNA-damage test could aid drug development
...ng test. Additionally, he experimented with mutant mice created by Samson's lab that are deficient in certain DNA-repair systems. The bone marrow cells derived from these mice, and the cells cultured from that bone marrow, proved more sensitive to the toxic agents than were the cultured cells from normal ...Study revises dynamin's role in nerve cell function
...zyme was essential to all synaptic activity, these mice would die very soon after birth. But the pups we...Lab study revealed that synaptic activity in these mice was functioning at a low level -- enough to keep the mice alive over the short term -- without dynam...LIAI scientists make important finding on cytomegalovirus transmission
...ion of the IL-10 protein in the salivary glands of mice by inhibiting binding of IL-10 to its receptor. "...cond approach, which used a stimulator antibody in mice to boost the action of the OX40 protein. OX40 helps T cells replicate more quickly, thus building t...Researchers publish first marsupial genome sequence
...erences between placental mammals, such as humans, mice and dogs, and marsupial mammals, such as opossums and kangaroos. "Marsupials are the closest living relatives of placental mammals. Because of this relationship, the opossum genome offers a unique lens though which to view the evolution of our own...Survival of the rarest: Fruit flies shed light on the evolution of behavior
...ene is found in many animals, including honeybees, mice and humans, the researchers are examining how variations in the human foraging gene may be linked to food-related disorders. ...InfoSNM highlights advances in computer, information sciences for molecular imaging
...n; 4-D phantoms for medical imaging simulation of mice and men; coregistration and visualization of cardiac CT studies and dynamic PET studies using scene-graphs, direct volume rendering and 2-D transfer functions; and comparative evaluation of serial hybrid imaging studies for quantitative assessment ......olocalized with mutant AR in neurons of SBMA model mice (AR-97Q) and in patients with SBMA. Overexpression of CHIP in normal mice caused no apparent developmental or motor impairment. However, in AR-97Q mice, overexpression of CHI...