Story tips from the Department of Energy's Oak Ridge National Laboratory, October 2004
...nd the University of Tennessee outline a system of microarrays of vertically aligned carbon nanofibers. Using advanced fabrication methods, researchers can control the length, diameter, shape, position, orientation and chemical composition of the nanofibers. The nanofibers can be arranged to create tiny fluid-fi...Genetic data crunching achieves milestone at Stanford
...es. The problem, however, is that experiments with microarrays yield vast amounts of data. "Microarrays allow res...ith microarrays. "It's much less scary to be doing microarrays at Stanford than anywhere else," Ball said. "In fact, if you're not, you have to explain why." It's ...Genetically endowed worm may substitute for rodents in some toxicology testing
... to build proteins, can then be measured on custom microarrays and compared with the genomes of nematodes that have not been exposed to chemicals. "We will look for changes in the expression of every gene in the animal caused by a given chemical," Freedman said. "We need to come up with microa...Powerful 'toolkit' developed for functional profiling of yeast genes
...ed in its genome. The researchers then use special microarrays to find out how much of each mutant is present. An...icular gene, nurture the ones that make it and use microarrays to see quickly which ones are missing." The researchers dubbed the combined technique dSLAM, f...By impounding iron, FHC foils cell suicide, fuels inflammation
...ry of potential protective genes. Next, they used microarrays to detect the genes that were boosted most though this selective process. "This system told us which genes were most enriched by selection," Franzoso said, which provided "a semiquantitative indication of protective efficacy." When they looked clos...A global view of gene expression in the aging kidney
... with age. Kim and colleagues then used DNA microarrays to determine the activity of every gene in all the kidney samples. Of 33,000 known human genes on the microarray, 985 showed age-related changes. Although cortex and medulla have different cell types and perform different functions, their gene...Case announces launch of gene expression analysis software
... BAMarray analyzes the genomic data extracted from microarrays and produces lists of genes that show biologically interesting expression profiles across experimental groups. The software provides both diagnostic and inferential graphical plots to help users better understand their data. The user can interactive...Agilent Technologies announces breakthrough for cancer researchers studying chromosomal changes
...on and throughput. Efforts in recent years to use microarrays to overcome these limitations have been hampered b...croarray manufacturing, Agilent can deliver custom microarrays designed to explore either the entire genome or specific regions of interest, according to project n...Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats
...ents including the measurement of gene activity by microarrays showed that saturated and trans fats caused greater activity of the gene that makes PGC-1beta co-activator than did unsaturated fats. The research also showed that when the fats triggered PGC-1beta, the co-activator interacted physically and turned u...Alcohol's effects on gene expression in the central nervous system
...e the quantitative and qualitative applications of microarrays to studying the genetic and biological bases of alcoholism and alcohol abuse within discrete brain regions. "For researchers, microarray technology has the potential of studying the genetic and biological bases of alcohol's rewarding effects, sensit...Chemical engineer Kao explores antibiotic synthesis with DNA chips
...-producing bacteria to increase their yields. DNA microarrays Without a tool known as the DNA microarray, or DN...n the lab of biochemistry Professor Patrick Brown, microarrays use both computer technology and DNA base pairing to track the expression of thousands of genes simu...UCLA launches $20 million stem cell institute to investigate HIV, cancer and neurological disorders
...integrated microfluidics to aid in cell isolation, microarrays and shape encoded particle approaches for gene expression analysis, proteomics using advanced mass spectroscopy, large-scale computational facilities for bioinformatics, and world-class multi modality imaging facilities for analysis of stem cell ther...Two UCSF scientists receive top funding honor from medical institute
...vity is revealed on a glass slide. He has used the microarrays he designed to make major advances in understanding such infectious diseases as SARS (severe acute respiratory syndrome) and malaria. Shokat, a leader in the new field of chemical genetics, has developed a number of innovative techniques to tease apa...University of Pittsburgh gets wired for speed with Apple Xserve G5 cluster
...attaca's workload even more by analyzing data from microarrays and large SNP-chip studies, which can involve as many as 100,000 markers. "This will greatly increase the number of computations required for a genetics project, but Gattaca has the horsepower and storage capacity to handle whatever we throw at it," ...Standardized microarrays may bring us one step closer
...nd reliable results when using a technology called microarrays or gene chips. Microarrays allow scientists to see...rs also found that using commercially manufactured microarrays produced the best results that can be more easily replicated. Using microarrays made in-house by ea...Meeting to explore possible gene expression consortium
...hole genomes and the development of so-called gene microarrays have fueled an explosive growth in data on genes and their functions. Gene microarrays use thousands or tens of thousands of short lengths of single-strand DNA, fixed in a grid about the ...Method holds promise in identifying markers of non-metastatic vs. metastatic breast cancer
...he beauty of the Montel et al. study is the use of microarrays to analyze variations in gene activity between cancer cell lines with differing capability to spread to distant organs (metastasize) but derived from the same human breast cancer. This eliminates the problem of irrelevant genetic variability among t...Motor transport in bio-nano systems
...instructive example: When integrated into existing microarrays for DNA and RNA hybridization, these transport systems would act to increase the hybridization rates. In general, biomimetic systems based on molecular motors and filaments have many potential applications in bionanotechnology, pharmacology, and medi...Study: 'homemade' gene expression technology unreliable
...everal OHSU colleagues one of three articles about microarrays appearing this month in the journal Nature Methods...an genome mapping has made the production of these microarrays possible," Spencer said. "Our interest is in how environmental factors drugs, pollutants, workplace......f an individual's genetic code. Scientists use DNA microarrays to discover and analyze a person's DNA or messenger-RNA genetic code. This allows for, say, the early diagnosis of liver cancer, or the prediction of the chances that a couple will produce a child with a genetic disease. Frequent, widespread use of t...