Life detection instrument passes key test on road to Mars
...ab to look for homochirality in amino acids. These microarrays with microfluidic channels are 100 to 1,000 times more sensitive for amino acid detection than the original life detection instrument flown on the Viking Landers in the 1970s. The Atacama Desert was selected by NASA scientists as one of the key spots...Whole genome promoter mapping - Human Genome Project v2.0?
...ne from 'junk DNA.' Using a set of NimbleGen's DNA microarrays that represent the entire human genome, the team was able to track critical proteins binding to each gene's promoter to identify 10,567 active promoters, 6 091 of which were previously unknown. LICR's Dr. Bing Ren, the senior author of the study and...Researchers pinpoint genes that drive spread of breast cancer to lungs
...nalyzed the activity of the cells' genes using DNA microarrays -- which are capable of measuring the activity of a vast number of genes at once. This analysis revealed a "metastasis signature" of genes whose activity uniquely distinguished the cells that aggressively spread to the lung. Generally, these genes co...Consortium seeks comment on gene expression roadmap
...t will be used to establish the performance of DNA microarrays and other quantitative experiments that measure gene expression. The National Institute of Standards and Technology (NIST) is a founding member and host of the consortium. Gene expression--how and under what conditions specific genes produce which pr...ASHG 55th Annual Meeting, Salt Lake City, October 26-29, 2005
...e human genome sequence. These include the use of microarrays to simultaneously analyze the expression of thousands of genes during development and disease processes, the identification of genetic factors in behavioral and communication disorders, and discussions of newly discovered genes for voice development ...Electrical engineer works on personalizing medical treatment
...imprinted with DNA and its thousands of genes. The microarrays get 'washed' with a solution carrying fluorescent ... working with similar technology involving protein microarrays to study cancer at an even more precise level. The area of study, called proteomics, is expected to ...Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer
...tion methods to make thousands of sensors and have microarrays of these to detect cancer proteins." The researchers plan to test the technique with additional breast cancer markers, as well as with markers for other cancers. They are also planning to perform animal studies, examining the sensitivity of the anti...Yale scientists decipher 'wiring pattern' of cell signaling networks
...ts Jason Ptacek and Geeta Devgan used proteome microarrays to assay the thousands of different proteins in a ...in the yeast cell, were tested separately with the microarrays to determine which proteins were modified by each kinase. From the wealth of information generated b...Carnegie Mellon U. transforms DNA microarrays with standard Internet communications tool
...ivation in living, complex biological systems. DNA microarrays monitor the behavior of thousands of genes over ti...and cost-effective," Bar-Joseph added. "While DNA microarrays are very powerful, they present a sampling problem," Bar-Joseph said. "DNA microarrays only take sta...Blazing a new path for Emery-Dreifuss Muscular Dystrophy
...altered mice, the researchers used "gene chip" DNA microarrays to rapidly screen for changes in expression levels. Unlike normal mouse hearts, the mutant hearts showed increased expression of genes encoding MAP kinases, which were previously implicated in heart hypertrophy and failure. These same experiments als...Absence of critical protein linked to infertility
...e than four years ago. First, researchers used DNA microarrays to identify gene expression under normal and abnormal conditions during implantation. After messenger RNA profiling zeroed in on C/EBPb's activity, the researchers collaborated with Peter F. Johnson of the National Cancer Institute's Laboratory of Pr...Sexual differences in immune response appear at puberty
...olleagues from other institutions in the USA, used microarrays to study 12,000 genes expressed in the spleen of pre-pubertal, pubertal and post-pubertal male and female mice. Lamason et al.'s results show that a number of genes are upregulated in both males and females during puberty. The authors found that gene...Predicting chemotherapy outcome
...nd Marie Curie University, Villejuif, France, used microarrays to analyse the gene-expression patterns of samples from colon tumours and liver metastases collected from 13 patients with colorectal cancer. The microarray analyses were carried out before the patients were treated with combined chemotherapy of foli...Targeting the dosage compensation complex
...unoprecipitation combined with high-throughput DNA microarrays (ChIP on Chip) to map DCC binding along the X chromosome in various biological contexts. Taken together, the papers show striking recruitment of the DCC to coding sequences, rather than upstream regulatory regions on the X chromosome, also excluding ...Study shows gene candidates for predisposition
...more than 4.5 million data points on more than 100 microarrays from mouse models, also identified more than 1,300 functional groups, including signaling and transcription pathways, which may also play an important role in establishing a capacity for a "high level of alcohol consumption." The results of the stu...Key root-development pathway mapped using advanced genomic technique
...a from multiple genetic analyses using several DNA microarrays -- popularly known as "gene chips." Each of these ... SHR. That "meta-analysis" of the results from the microarrays revealed eight genes that appeared likely to be direct targets, as well as numerous genes that appea...News tips from The Journal of Neuroscience
...of a behavioral genetics approach. They fabricated microarrays containing >26,000 mouse cDNAs. Gene expression patterns were measured across five brain regions--the prefrontal cortex, ventral striatum, temporal lobe, periaqueductal gray, and cerebellum--and across eight inbred strains of mice that are consi...Proteus mirabilis will give up its genetic secrets at ASM meeting
...lution." In future research, Pearson will use gene microarrays to identify the Proteus mirabilis genes that are turned on, or expressed, during the infection stage. Genes involved in the infection process will be prime targets for future vaccine development, according to Pearson, although she says that years of ...RNAi Global Initiative members advance standards for genome-wide RNAi research in second meeting
...of accepted research standards for the new tool of microarrays in the 1990's cost the life sciences research community many years of progress. By tackling the need for standards early-on, RNAi Global is accelerating the way we will be able to work with genome-wide siRNA libraries, which in turn has the potential...Einstein researchers take the pulse of a gene in living cells
...rong part of the body. Researchers customarily use microarrays (also known as "gene chips") to assess gene expre...ther tissues. But with millions of cells involved, microarrays reflect only "average" gene expression. Just how a gene is transcribed in a single cell--continuousl...