Speeding the search for elusive chromosomal errors
...retches of DNA within a sample being tested. These microarrays hold more than 100,000 DNA oligonucleotides, which...entire complement of DNA in a cell nucleus. "These microarrays provide more rapid and precise results than karyotyping, and offer as much as 50 times higher resolu...HHMI helps physicians launch careers in research
...han 75 human diseases that have been studied using microarrays make it difficult to integrate all the data and figure out how it can be used to prevent or treat disease. Butte is developing novel computational techniques for analyzing and comparing large amounts of differing data. He co-authored one of the first...Untangling a pathology of Alzheimer's
...m of human tau that causes neurodegeneration. Such microarrays enable researchers to determine the activity of thousands of genes at once. The gene for PSA was among those they identified as more active in the resistant cerebellum. In studies with the fruit fly Drosophila, they found that higher activity of the...Berkeley lab life scientists are leaders in team to detect cancer by studying proteins in the blood
... development. "We'll use special high-throughput microarrays to look for differences in the way tumor genes are spliced," says Conboy. "The purpose is to identify these aberrant splicing patterns at the exon level." Once aberrant patterns of exons have been identified for key proteins associated with breast ...UCSF set to transform itself into engine of translational research
...ed in the work of Joseph DeRisi, PhD, a pioneer of microarrays who has established collaborations using the tool to explore the possible role of viruses in cancers, asthma and a host of other diseases; James McKerrow, PhD, who is also focused on diseases of the developing world; John Kane, MD, who is searching f...Researchers identify a key regulator for skin stem cells
... gene on at will in skin cells. They then used DNA microarrays to analyze which genes were affected when Tcf3 was activated. Microarrays, also known as "gene chips," enable scientists to determine the activity of thousands of genes at once. "When we compared the list of genes that Tcf3 repressed or induced, we...Mutant gene causes severe kidney disease in infants
...up until later in life." U-M scientists used DNA microarrays to analyze blood samples from 26 families around the world who had children diagnosed with steroid-resistant nephrotic syndrome. After eliminating known mutations, the study team was left with DNA from 12 children with the disease. All 12 had inherit...Selecting life: Scientists find new way to search for origin of life
...erwhelmingly large number of possibilities." DNA microarrays provide a means to address this problem. Microarrays are produced robotically to spot tens of thousands of microscopic droplets of DNA from as many genes onto a slide, enabling scientists to measure which genes are turned on. This rapidly developing ...Unraveling where chimp and human brains diverge
...nd biostatistics, the UCLA team used data from DNA microarrays vast collections of tiny DNA spots -- to map the activity of virtually every gene in the genome simultaneously. By comparing gene activity in different areas of the brain, the team identified gene networks that correlated to specific brain regions....Children's Hospital researcher leads multipronged attack on infant leukemia
...n, M.D., of the University of New Mexico, will use microarrays (DNA chips) to identify drugs that may selectively attack cells with MLL translocations. The project also seeks to unravel the molecular circuitry in leukemia cells in order to predict those infants most likely to benefit from specific targeted drugs...First biomarker for human sleepiness identified in fruit flies
...s to different kinds of sleep deprivation and used microarrays to look for changes in activity in many different genes. Amylase levels consistently changed after sleep loss. Amylases are a family of enzymes found in the saliva that break down starch. To verify amylase's connection to sleep loss, Shaw's lab moni...Scientists develop method to find genetic basis for plant variation
... Salt's method combines the new technology of DNA microarrays with information from a large genetic database in ...idopsis, Salt said. For an answer, Salt used DNA microarrays to detect genes that varied in the two coastal populations. He cross-referenced this information wit...Scientists map key landmarks in human genome
...leosomes are located." The researchers used gene microarrays to which DNA associated with single nucleosomes was added. The nucleosomal DNA was derived from several cancer cell lines including melanoma and breast cancer, as well as several normal human cell types. A critical component of the analysis involved ...Study identifies common flaws in oncology microarray studies
...gle glass slide. In oncology, scientists have used microarrays to study unique gene expression patterns of specific tumor types, to discover new drug targets, and to categorize unique characteristics of a particular tumor to help doctors tailor treatments to an individual patient. However, such studies produce v...Almac Diagnostics announces pioneering genetic research on colorectal pre-malignancies
...tic's range of Cancer DSA research tools are novel microarrays developed to enable accelerated research in discov... to deliver clinical applications. As the first microarrays based around the transcriptome of an individual disease, this technology generates significantly mor......t proteins from heat-related degradation. By using microarrays to assess activity of A. pisum and Buchnera genes, the researchers discovered that after a four-hour exposure to 35 C temperature, some of their laboratory strains of Buchnera upregulated the heat-shock genes, but others did not. Further analysis sho...Liver regeneration may be simpler than previously thought
...r liver were removed. Using techniques such as DNA microarrays which determine which genes are active in a cells and software programs that analyze the collected information, the scientists listed all the proteins that help the cells grow and proliferate in both samples. The results were unexpected. The re...DNA sequence of Rhesus macaque has evolutionary, medical implications
... macaque. "In the future, we hope to develop DNA microarrays or gene chips specific to the macaque, which will enable us to pinpoint the level of gene expression in various studies such as those that look at the virulence and pathogenicity of pandemic strains of the influenza virus," said Dr. George Weinstock,...An electroacoustic path to custom-made gene chips
...ast year for demonstrating a new way to create DNA microarrays has improved the technique to make it much more powerful. DNA microarrays, also known as gene chips, are a basic tool for modern medicine and biology, allowing researchers to detect whether a certain message sequence is present or absent in a given...Burroughs Wellcome Fund awards $14M to support physician-scientists
...special founder populations using high-density SNP microarrays Christopher Newton-Cheh, M.D. Harvard Medical School Genomic dissection of QT interval duration and sudden death Dao Nguyen, M.D. University of Washington The stringent response in Pseudomonas aeruginosa biofilm formation and antibiotic toler...