Breakdown of myelin insulation in brain's wiring implicated in childhood developmental disorders
... brain development through childhood and well into middle age, when development peaks and deterioration begins (Neurobiology of Aging, January 2004). He also identifies the midlife breakdown of myelin as a key to onset of Alzheimer's disease later in life (Archives of Neurology, March 2003; Neurobiology of ...... such as those tissues involving infections of the middle ear, of the prostate gland, pneumonia in patients with cystic fibrosis, osteomyelitis, etc. In the interior of the biofilm, bacteria present greater resistance to antibiotics, to the opsonisation by antibodies and to phagocytosis, which explains the...Resetting epigenetic code could aid lupus patients
... strike some while they are still young, others in middle age and others not until old age? Mishra said the proteins expressed through the histones vary between healthy individuals and lupus patients. There also is variation among lupus patients. These differences may explain why some lupus patients develop...New ECCO 13 data emphasise vital importance of cervical cancer detection, treatment and prevention
...ng birth to many children. It is commonly found in middle aged women and of women from poor socioeconomic status groups.1, 2 There are very few specific new treatments for cervical cancer which follows the traditional route of surgery, radiotherapy and chemotherapy. However if the cancer is caught early it ...Yale receives Science Education Partnership Award to increase science literacy
...Medicine, will design science curricula, targeting middle school students, to create a better understanding of the dynamics and biology of how disease is transmitted. Yale will receive five years of support from the SEPA grant -- a total of $1.3 million of the $9.4 million SEPA fund. It will be administere...Study provides insight into cellular defenses against genetic mutation
...s that the stop codon has mistakenly fallen in the middle of a set of instructions. Specifically, Medical Center researchers now believe a stop codon is labeled premature when it occurs more than 55 nucleotides upstream (toward the 5-prime end) of an exon-exon junction. If these spatial requirements are ...U. of Colorado researcher identifies tracks of swimming dinosaur in Wyoming
... of any dinosaurs in the Wyoming region during the middle Jurassic, she said. The dinosaur does not have a name, although Mickelson is continuing to look for bones and other remains that could be used to identify and name the new species. "This dinosaur is similar to a Coelosaur," she said. "It is a dino...AAAS science literacy project 20th anniversary, Oct. 17-19
...r Project 2061's studies of 44 of the most popular middle and high school science and mathematics textbooks found that very few were adequate in helping students learn key ideas. Furthermore, Project 2061, with the help of the AAAS Education and Human Resources office, has been working with science centers ...Latest study: Scientists say no evidence exists that therapod dinosaurs evolved into birds
...e from digits 2, 3 and 4, the equivalent of index, middle and ring fingers of humans. To change so radically during evolution would be highly unlikely. "If birds descended from dinosaurs, we would expect the same 1, 2 and 3 pattern," he said. Current dinosaurian dogma requires that all the intricate adaptat...The brain needs the middle ear to track depth
...from the motion-detecting vestibular system in the middle ear. In studies with monkeys reported in the October 6, 2005, issue of Neuron, Nuo Li and Dora Angelaki of Washington University School of Medicine in St. Louis have demonstrated how such depth motion is updated and strongly implicated the vestibular...First big influenza genome study reveals flu evolution
...rafting emerging vaccines that work. "Right in the middle of flu season, we could determine which influenza strains are present in the population, which ones are dominant, and how well a given vaccine works," Ghedin notes. She adds that all sequences described in the current study have been deposited in pub...Learning how SARS spikes its quarry
...critical amino acids turned out to be right in the middle of the interface between the spike protein and the receptor," said Harrison. Thus, the structure reveals details about how even small mutations in the spike protein gene that alter the identity of amino acids at those sites can affect the virus's abi...Skull study sheds light on dinosaur diversity
... sauropods were common in North America during the middle of the dinosaur era but were thought to have been pushed to extinction by more specialized plant-eaters at the end of that era. New discoveries, however, are showing that one lineage of sauropods diversified at the end of the dinosaur era, University...Old drug shows new promise for Huntington's Disease
...cause the disease often manifests in early to late middle age after the carrier's children have already been born. During the course of the disease, the Huntington's gene causes the production of a toxic protein, mutant huntingtin, in neurons (brain cells). Eventually the protein kills the neurons, causing...Scientists develop 'clever' artificial hand
...ey built the Remedi-Hand in three parts the three middle fingers are very similar in size and movement so they made those identical. The pinky is a smaller version of the same. Each of these four fingers are made up of a motor attached to a gearbox attached to a carbon fibre finger. All of this is fitted t...A double punch for female survival
...ar, with a protein-encoding part sandwiched in the middle between regulatory regions near the head and the tail. Most research has focused on interactions between the head region and the ribosome, because it is here that cells assemble a "docking bridge" for the protein-synthesis machinery. Scientists have ...Gap-climbing fruit flies reveal components of goal-driven behaviors
...y is the formation of a "bridge" with the hind and middle legs still holding on to the starting side and the...the most to gap-crossing. Auxiliary actions of the middle legs keep the body close to a horizontal position and help in reaching the other side. In the last s...Sticky mutant proteins implicated in Lou Gehrig's disease
...setts Medical School. "It typically strikes during middle age, and although it may start with only mild weakness, the symptoms can spread insidiously over months to impair mobility, speech and swallowing, and ultimately the muscles required for respiration." Despite the prevalence of ALS, the biological mec...Firefly protein lets researchers monitor molecule linked to cancer
...ature Methods. IKK stands at a pivot point in the middle of an important set of linked chain reactions known as the NF-KappaB pathway. The pathway can start at many different receptors on cell surfaces; its finish changes the activity levels of varying genes. The result, according to Piwnica-Worms, is that...... small pear-shaped island of Samoylov in the lower middle of the image is one of the Delta's more than 1 500 individual islands. The Lena Delta, covering an area of about 32 000 square kilometres, is a haven for Arctic wildlife that transforms for five months each summer from frozen tundra to fertile wetlan...