Molecule that helps DNA replicate may make good target for cancer therapy
...cause disrupting this interaction in a cancer cell might prevent it from multiplying. Also, the researchers want to know what it is in the cell that causes the degradation of the polymerase alpha complex when no Mcm10 is around to protect it. Bielinsky and her group are now beginning to work with chicken b...Mouse study: 'Critical' Down syndrome region isn't
... specific problems caused by a triple genetic dose might be modifiable -- if we can figure out the key players." As part of this effort, Olson used a technique to precisely duplicate a defined chromosome segment and applied it to the DSCR section on mouse chromosome 16, the analog of human chromosome 21. S...Clues to improving TB treatment
...amine the molecular structure of EthR to see if it might hold the key to improving the effectiveness of dru...n this case, a compound that alters EthR structure might also be a good partner for the drugs that treat leprosy. Nearly one third of the world's p...Single genetic defect links many risk factors for heart disease and stroke
... magnesium," said Lifton. "That suggested that she might have a new disease, because all the known genetic ...n of whether the more common forms of these traits might arise from abnormal mitochondrial function as well." Lifton noted that although about half of the f...Researchers discover gene mutations for Parkinson's disease
...sessed each gene in this region for mutations that might cause disease. The investigators identified two mutations in the same gene, one associated with Parkinson's disease in the Basque families and the other which was linked to the disease in the English family. "The discovery of this cluster of Basque...Genetics play role in response to most common asthma drug
...sted that genetic differences in the beta-receptor might play an important role in how patients respond to ...In the future, patients with the arginine genotype might even be advised to use an alternate reliever medication." The National Asthma Education and Preventi...New method studies living bacterial cells
...e results suggest that X-ray fluorescence analysis might be useful for determining whether a bacterial cell is living or dead. "No other technique has been capable of determining the metabolic state of a single hydrated cell and the chemical speciation of metals on, in or near a bacterial cell," Kemner sa......to the cerebellum. Blatt had theorized that the IO might be a site where receptor levels were different, be...gnal." Such improved processing might manifest as the potential for the great mental capabilities seen in autistic savants, although this ...Early life stress harms mental function and immune system in later years
...f mother-infant interaction on chromatin structure might define a basis for the development of stable individual differences in hormone function and behavior over the lifespan." ...OHSU scientists identify key gene that delays female puberty
...d his colleagues now are tracking other genes that might interact with TTF-1 in the brain to control the onset of puberty. "While observational studies are required to determine the role of TTF-1 in humans, we know that children recently described to have mutations of this gene suffer from loss of motor ...Sandbagging cancer in the bloodstream
...ndbagging the tumor cells in the bloodstream--this might have a positive therapeutic effect on patients wit...ity with something known as a Src kinase inhibitor might turn off metastatic tumor cells' exit strategy from the bloodstream. They examined the question by t...Cars, not crops, should be chief targets in reducing greenhouse gases
..., compared to cutting down on the emissions as you might with simple technologies like driving hybrid cars that get twice the mileage. "Taking a third of our crop land out of production and using it to sequester carbon would mean very high prices for food in this country and a lot of hungry peo...Farmers don't need a new superstar toxin to fight bugs
...f the genetically resistant insects that otherwise might invade the main crop. "We used mathematical models to test this concept, and we were very surprised by the findings. Although these results are exciting, we are well aware that a number of issues must be addressed before this approach can be...A clear view of mycobacterial infection
Fighting an infection might seem to be a battle between David and Goliath, giv...even recruits more macrophages to granulomas. This might seem an odd strategy, as macrophages are required for mycobacterial elimination. But in this ongoing...Mystery unwrapped: Texas A&M team uncovers mummy secrets
...ade routes used at the time," Kennicutt adds. "We might uncover some other interesting information about how the Egyptians used tar and how trade was conducted all these many years ago." ...Gene therapy approach reverses diabetic neuropathy in animal model, Pitt study finds
...rovide the earliest evidence that such an approach might some day help people with diabetes, in whom neuropathy is a common complication that causes irreversible nerve damage. Details of the research were presented today at the 34th Annual Meeting of the Society for Neuroscience, being held Oct. 23 27 in ...Munching microbes could cleanse arsenic-contaminated groundwater
...suggest that groundwater contaminated with arsenic might be easily identified and remediated. "Unlike detec...ding sulfate to naturally contaminated groundwater might be a simple but effective method to sequester the arsenic, Kirk said. "The bacteria are already pre...Academics work to help stressed-out cats
...s in the cats' environments and temperaments which might be causing this condition." This latest, questionnaire-based study compared 31 cats with FIC to 24 cats in the same households that did not have cystitis. These were in turn compared with a control group of 125 healthy cats. Dr Gunn-Moore said: " Alt...UCSD biologists discover chemical important in guiding visual system development
...mechanism that generates this spontaneous activity might make it possible to recreate it later in life; for...y in development. To find the factor that might be responsible for coordinating the behavior of the retinal ganglion cells, Feller and Wang took ele...Common household fragrances may be harming aquatic wildlife, study finds
...cate that the effects on the first line of defense might be irreversible or continue long after the event. It's a warning sign. It's a smoking gun. Are there other chemicals out there that have similar long-term effects? Could these be harming these defense systems in aquatic organisms? And could they be h...