Tag: "missing" at biology news

UCLA researchers identify key enzyme linked to childhood blindness

...archers at UCLA have discovered that RPE65, a gene missing in infants born with the blinding disease Leber congenital amaurosis, is also a key enzyme in the visual cycle. The identity of this enzyme has long been a mystery to scientists. The study, "Rpe65 is the Retinoid Isomerase in Bovine Retinal Pigment ...

No small feat: First ever gene therapy success for muscular dystrophy achieved

... cell's outside scaffolding and reestablishing the missing link to key structures inside the cell. Clearly, the authors are most excited about the impressive results achieved in their experiments using systemic gene delivery, which proved there could be significant therapeutic improvements and even be life-s...

Alteration of brain protein regulates learning

...esearchers created mutant mice in which Apoer2 was missing the spliced portion, they found that the mice had difficulties with learning and memory. They were slow to learn where a hidden platform was in murky water, among other tasks, and when the electrical activity of neurons was measured in the hippocampu...

Gene discovery sheds light on causes of rare disease, cancer

...emia) and is associated with birth defects such as missing or extra thumbs and skeletal abnormalities of the hips, spine, or ribs. Many who have FA eventually develop acute myeloid leukemia and are prone to head and neck, gastrointestinal, and other cancers. The first symptoms, such as nose bleeds or easy br...

Scientists focus on 'dwarf eye'

...ans and discovered that the protein was completely missing from nanophthalmos patients. In a normal human eye, the MFRP protein is located on the surface of the retinal pigment epithelium (RPE), which is located beneath the retina and helps maintain photoreceptors, the eye's light-detecting cells. Blindness ...

Studies find possible drug targets for improving vascular health

...ue to ischemia. In the PNAS study Sessa used mice missing the endothelial nitric oxide synthase gene and fou...n using gene therapy to reverse the effects of the missing gene, which rescued limbs in danger of dying because of ischemia. Ischemia is a severe reduction of ...

The link between fasting and acute attacks of porphyria

A team of researchers has discovered a molecular missing link that helps explain why fasting brings on acute attacks of the genetic disease hepatic porphyria, according to a new report in the 26 August issue of the journal Cell. The finding could help improve treatments for those suffering from the disease...

Cellular power plants also fend off viruses

...seeking a regulatory molecule that would provide a missing link in the activation of two important triggers o...latory molecules. They initiated a search for this missing molecule by searching for proteins in the cell that contain a characteristic molecular domain, calle...

Cancer therapies during childhood can damage developing teeth

...t stem cell transplantation. The highest number of missing teeth was 12. Those who had been over five years o..., which, however, slightly increased the number of missing teeth. The children also had a high frequency of microdontia, teeth smaller than normal (44% as oppo...

New genome comparison finds chimps, humans very similar at DNA level

...More than 50 genes present in the human genome are missing or partially deleted from the chimp genome. The corresponding number of gene deletions in the human genome is not yet precisely known. For genes with known functions, potential implications of these changes can already be discerned. For example, the ...

Researchers identify molecular anchor that allows bacterial invasion of central nervous system

...t of the mice survived when infected with bacteria missing the single iagA gene," Doran said. "Blocking the anchoring of LTA on the bacterial cell surface could become new a therapeutic target for preventing bacterial meningitis." Doran and Nizet noted that the study focused on how bacteria can begin the in...

Scientists get first glimpse at how plants, most animals repair UV-damaged DNA

... visible light to repair UV damage. This enzyme is missing in all mammals, including humans, although all plants and all other animals have it. Greater understanding of how photolyase works could one day lead to drugs that help repair UV damage in human DNA. In the online edition of the Proceedings of the Na...

New tooth enamel dating technique could help identify disaster victims

...umber of people you need to look at from a list of missing people." Livermore officials are providing information on the enamel dating technique to federal agencies as part of the Laboratory's scientific and technical assistance in response to Hurricane Katrina. LLNL also is assisting in setting up emergency...

Stressed cells spark DNA repair missteps and speed evolution

..., special protein machinery in the cell copies the missing DNA from another chromosome and rejoins the broken ends around the newly synthesized genetic material. "It fixes the hole in the DNA by copying similar information," said Rosenberg. However, when the process goes wrong, the repair process introduces...

Cellular dumping site is not garbage after all

...er the appropriate conditions. Parker said, "Cells missing these proteins could no longer turn off mRNAs and could no longer make P-bodies." The team then engineered yeast cells to produce an overabundance of the proteins and repeated the experiments with those cells. Those cells stopped growing. Parker said...

Cancer drug might help kids with fatal 'aging' syndrome

... Hopkins researchers immediately noticed that also missing was the specific point at which the modified end would normally be chopped off -- a biologically crucial event. "The normal mammalian protein, lamin A, doesn't have all those modifications; the modified part is thrown away," says Michaelis. "With the...

Researchers show key protein necessary for normal development of red blood cells

...VCU, and the research team compared mice that were missing the gene for KLF2 to normal mice. They found that the KLF2-deficient mice produced embryonic red blood cells that appeared abnormal, were more likely to undergo cell death, and produced significantly lower amounts of globin mRNA than those found in n...

Rhythm gene discovered

... couldn't eat," Maricq says. The worms were not missing the mouth or other body parts, "but there was no pumping of the pharynx," he adds. As a test, the biologists inserted the gene back into the pharynx, but not the rest of the worm. As a result, the worms could eat and develop to adulthood, but then de...

Egg's energy stores key to preserving fertility

...pharmacology and cancer biology. Also, female mice missing the gene to produce caspase-2 are born with an excess number of oocytes. "We've really demonstrated that caspase-2 is the thing required for oocyte death, and provided a specific molecular mechanism that can keep it shut off," Margolis said....

Cells from amniotic fluid used to tissue-engineer a new trachea

...atening: babies born with incomplete, malformed or missing tracheas cannot breathe and must immediately go on heart-lung bypass, which can cause neurologic and other complications. Surgeons have tried various fixes, such as grafting in pieces of the baby's rib or pelvic bone, using synthetic substances like ...

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(Date:8/21/2014)... in near darkness use a previously unknown process for ... team led by a Penn State University scientist has ... aimed at improving plant growth, harvesting energy from the ... on Lake Erie and other lakes worldwide. A paper ... Science Express edition of the journal Science ...
(Date:8/21/2014)... fungus linked to dandruff, eczema and other itchy, flaky ... further global reachesincluding Hawaiian coral reefs and the extreme ... A review in the scientific journal PLOS Pathogens ... fungi of the genus Malassezia in light ... from around the world. , University of Hawai,i at ...
(Date:8/21/2014)... food intake, health and quality of life of older ... at the University of Waterloo receiving close to $1.5 ... Research (CIHR). , Professor Heather Keller, of the ... Schlegel research chair in nutrition and aging, will receive ... living in long-term care homes are poorly nourished. The ...
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