Study shows metabolic strategy of stressed cell
...s that use CoA, the cell can concentrate it in the mitochondria where it's needed most." "The metabolic changes...cells of the body maintain enough free CoA for the mitochondria to keep producing ATP," said Yong-Mei Zhang, Ph.D., of the St. Jude Infectious Diseases department a...$7.9M awarded to UCI stem cell scientists
...rded $2.5 million to investigate the importance of mitochondria and mitochondrial DNA in the preparation of human embryonic stem cells for use in regenerative medicine. Mitochondria are found in human cells and generate most of our energy. They contain their own DNA, which contains key blueprints for maintaining ...How eating less might make you live longer
...rial function. Their analysis of genes involved in mitochondria formation indicated that CR and CREX both increased the number of mitochondria in muscle. Both interventions also reduced the amount of DNA damagea marker of oxidative stressin th...UCLA scientists garner 7 grants to fund leading-edge embryonic stem cell research
... Co-Investigator Utpal Banerjee: $635,024 Role of mitochondria in self-renewal versus differentiation of human embryonic stem cells. Principal Investigator Hanna Mikkola, Co-Investigators Owen Witte and Ken Dorshkind: $577,037- Improving microenvironments to promote hematopoietic stem cell development from ...UCI awarded $3.5 million for stem cell research
...s with focuses ranging from muscular dystrophy to mitochondria were selected by the Independent Citizens Oversig...iatrics, was awarded $623,500 to study the role of mitochondria in enabling human embryonic stem cells to develop into desired cell types. Mitochondria, which have ...Protein sensor for fatty acid buildup in mitochondria
...he connection between the location of PanK2 in the mitochondria and its role in as a sensor of energy demand," said Yong-Mei Zhang, Ph.D., a researcher in the Infectious Diseases department at St. Jude and the report's senior author. "This is an ideal location for PanK2 because it can detect acylcarnitine as it e...Good for the goose, not so great for the gander
...the body's largest producers of free radicals. The mitochondria also are unique in that they evolved from free-liv...e is better adapted to the female environment, the mitochondria in females just may work better, and longer, than those in males. This, Tower posits, might expla...Power-boosting signal in muscle declines with age
... the production, or biogenesis, of power-producing mitochondria that burn fat and fuel cells, according to the res...tochondrial biogenesis in muscle." The number of mitochondria within muscle largely determines its metabolic capacity. The mitochondrial composition of fibers in ...Taking heart failure to the MAT1
...f the proteins required for energy production. The mitochondria -- the cell's energy factories -- were defective. Further research showed that a particular protein called peroxisome proliferator-activated receptor-1 coactivator, or PGC-1, which is a known master regulator of energy production by cells, did not ...Researchers develop marker that identifies energy-producing centers in nerve cells
... structures, called mitochondria, in neurons, from mitochondria in other brain cells, called glia. Defects in mitochondria may be part of the process that leads to Alzheimer's and Parkinson's disease, as well as changes in ...New test predicts blood cancer's sensitivity to experimental cancer drug
...developing the test, the Letai team first isolated mitochondria from cancer cells; then they exposed them to protein fragments peptides that were known to interact with survival molecules like Bcl-2. "If they interact, then the cell is primed to die, and the test will identify which of the survival molecules is...Defective movement of cell's power plants implicated in commom inherited neurological disorder
...nefficient movement of cell's "power plants" - the mitochondria - within a cell, rather than their low energy prod...ver energy within the cell. A minor disruption in mitochondria movement reduces the energy supply, weakening or even killing the cell. In CMT, which affects 1 in ...Small molecule offers big hope against cancer
...ecently, researchers believed that cancer-affected mitochondria are permanently damaged and that this damage is th...tection from many standard chemotherapies. Because mitochondria regulate cell death--or apoptosis--cancer cells can thus achieve resistance to apoptosis, and this a...News tips from the Journal of Neuroscience
... cultured dorsal root ganglion neurons. Fragmented mitochondria clustered in cell bodies and proximal axons of the...port failure may result from reduced attachment of mitochondria to the microtubule transport apparatus, thus limiting delivery of energy supplies to long axons....'Marathon mice' elucidate little-known muscle type
...rgely determined by the number of energy-producing mitochondria they house. Myosins are motor proteins that consist of both "heavy" and "light" amino acid chains. While most muscles in mammals contain a mixture of slow- and fast-twitch fiber types, some muscle beds are enriched for one type or the other, Spiege...How appetite-stimulating brain cells work overtime during fasting
... (UCP2) that boosts the number of power-generating mitochondria in neurons that drive hunger. The increase in mitochondria, in turn, allows the brain's hunger center to remain active when periods of food scarcity result in a "negative energy balance," said Sabrina Diano of Yale University School of Medicine, who ...Male contraception -- UVa discovery stirring interest among basic scientists and drug developers
...cell organelles called mitochondria. In sperm, the mitochondria reside in a region called the midpiece. UVa rese...the other ATP/ADP carriers," Kim explained. "While mitochondria generate energy through an oxidative process, recent research indicates that the sperm flagella main...News tips from the Journal of Neuroscience
...romoter. In these mice, eYFP turned on in neuronal mitochondria when the animals received a doxycycline-free diet. With this model system, the authors will be able to ask all kinds of interesting questions, and in the best spirit of The Journal of Neuroscience, these mice will be made available to the community. ...History-hunting geneticists can still follow familiar trail
... Located within the hundreds of energy-producing mitochondria that lie outside the nucleus of our cells, mtDNA i...ed in the study. "Population geneticists have used mitochondria for all kinds of work for 20 years, and to think that mtDNA didn't correlate with population size wa...Study finds oysters can take heat and heavy metals, but not both
...e efficiency of metabolic processes in the oysters mitochondria the place where stored food is turned into the en...s of chemical reactions that occur in the oysters mitochondria in the process of cellular metabolism. The researchers found that cadmium affects mitochondrial ...