Mitochondrial DNA mutations play significant role in prostate cancer
...rate from nuclear DNA, is found in the hundreds of mitochondria located in the cytoplasm outside of each cell's nucleus. The mitochondria often are called the "powerhouse" of the cell because they produce about 90 percent of the body's en...JCI table of contents, December 1 2004
...hat inactivate bax and block its relocation to the mitochondria may be resistant to radiation therapy. This work may have significant clinical impact if the use of PGE2 could be shown to be effective for protection against radiation-induced gut injury in humans. TITLE: Prostaglandin E2 reduces radiation-induced ...Heart responds to fasting by remodeling vital energy-producing components
...ly consumed are the specialized internal membranes mitochondria use to generate energy-rich compounds for the cell... likely that the changes in the membranes make the mitochondria more energy efficient and serve as an adaptation to nutritional deprivation in mammals," says Richar...Sperm enzyme is essential for male fertility, study shows
...the cell. Specialized cellular structures known as mitochondria were thought to provide a substantial portion of t...Brien said. "Glycolysis may not be as efficient as mitochondria for producing energy, but the enzymes are abundant and in the right place for quick, localized energ...JCI table of contents November 1, 2004
...e work has indicated that rosiglitazone alters the mitochondria of fat cells, both in their structural features an...nes showed increased expression. Additionally, the mitochondria in the white fat cells of treated ob/ob mice had increased size and altered structure. The oxygen co...Diabetes drug works by enhancing fat cell energy production
...e work has indicated that rosiglitazone alters the mitochondria of fat cells, both in their structural features an...nes showed increased expression. Additionally, the mitochondria in the white fat cells of treated ob/ob mice had increased size and altered structure. The oxygen co...Single genetic defect links many risk factors for heart disease and stroke
... disorders. The mutation affects the genes of the mitochondria the energy-producing power plants of the cell that are passed from mother to offspring. The researchers are hopeful their discovery could help unravel the complex genetic and environmental factors that cause a range of metabolic disorders. The rese...Mitochondrial mutation linked to blood pressure and cholesterol problems
... in Science Express on line, suggests that altered mitochondria may account for the clustering as well as the diso... While this study focuses on a rare mutation in mitochondria that provides a clear link to specific disorders, mitochondrial function is known to decline with ag...Babies born after surgery on eggs
...ls, called mitochondria, to eggs. The team extract mitochondria from the granulosa cells that surround eggs and in...orks by replacing those with damaged DNA. In eggs, mitochondria have only one copy of this DNA, making them vulnerable to damage as women age. In contrast, mitocho...Antibiotic identified as potential anti-cancer candidate
...theory. They show that human Pdf is active in the mitochondria and is essential for cellular growth and proliferation. They have designed and created a class of new actinonin-based Pdf inhibitors, and have demonstrated that they selectively inhibit growth in several human tumor cell lines. They further demonst...Intracellular protein localization involved in new tumor progression pathway
...owed that by selectively targeting survivin to the mitochondria this enhanced soft agar colony formation, which is a standard laboratory technique to test for cells that lack growth control and are potentially tumor forming. In mice, when the authors carried out such mitochondrial targeting of survivin, this resu...Mitochondria findings may help beat wide range of disease
...the journal Science. "To understand the role that mitochondria play in both normal and aberrant cell biology, it ...ong to each "daughter" cell the full complement of mitochondria necessary for healthy cell physiology. Recent research suggests that when this process goes awry, he......eath-promoting factors from producing holes in the mitochondria which can result in calcium and destructive proteins leaking out into the cell. However, the overexpression of bcl-2 in damaged cells can lead to the continued division of the mutated cells and eventually cancer. The expression of the bcl-2 gene is...