Defective movement of cell's power plants implicated in commom inherited neurological disorder
...own is exactly how the mutated MFN2 protein alters mitochondrial transport. Piecing together this puzzle not only could lead to an enhanced understanding of how this phenomenon occurs, but may also reveal how to prevent or counteract it. The researchers also believe that there may be an additional and as yet unde...Toward more effective paleolgenetic analysis
...ntologists and archeologists. The work showed that mitochondrial DNA from freshly excavated, untreated fossil bones was amplified with a success rate of 46%. However, the rate is a mere 18% for fossil bones from collections which have been washed, dried and stored. A large part, on average 85%, of the genetic ma...Nevada scientist part of team that discovers hybrid speciation in butterflies in Sierra
...rom the eastern Sierra," Forister said. "But their mitochondrial DNA more clearly resembles those from the western Sierra. When you think about all of the changes the world has undergone, and how parental species have moved in response to climate change and have possibly come into contact many times, you realize t...Researchers develop marker that identifies energy-producing centers in nerve cells
...in questions, such as to what extent does neuronal mitochondrial dysfunction contribute to Parkinson's or Alzheimer... possible to explore how neuronal activity and the mitochondrial energy-producing system are coordinated and how the interrelationship works. The researchers say ...Sea creature's toxin could lead to promising cancer treatment
...easons: First, there is no previous report that a mitochondrial enzyme like OAT can play a direct role in mitosis; second, OAT seems dispensable for normal cell division occurring in mice and men but is required for the division of cancer cells. This may explain the cancer specificity of diazonamide," said Dr. Wa...Power-boosting signal in muscle declines with age
...dup in their muscle and livers and a deficiency in mitochondrial function, Shulman explained. These metabolic shift...er to maintain the same level of fat oxidation and mitochondrial biogenesis in muscle." The number of mitochondria within muscle largely determines its metabolic c...Good for the goose, not so great for the gander
...genetic inheritance, only the female passes on the mitochondrial genome to the next generation. Why, and how, this ...One expected effect of maternal inheritance of the mitochondrial genome, Tower suggests, might be a kind of Darwinian battle of the sexes played out on the genetic l...Exercise pivotal in preventing and fighting type II diabetes
...lizes insulin action in association with increased mitochondrial activity and fatty acid catabolism," will be published in the American Journal of Physiology-Cell....Protein sensor for fatty acid buildup in mitochondria
...nation of why the absence of this enzyme can cause mitochondrial malfunction." Rock is a co-author of the PNAS paper. The researchers showed that PanK2, is suppressed by CoAthe molecule this enzyme triggers the cell to make. CoA normally binds tightly to PanK2, shutting it down. When a buildup of fatty acids oc...UCI awarded $3.5 million for stem cell research
...io plans to create human embryonic stem cells with mitochondrial DNA mutations that cause human disease and examine...o generate into desired cell types declines due to mitochondrial dysfunction. If this hypothesis is confirmed, procedures for protecting mitochondria will be develop...DNA analysis reveals rapid population shift among Pleistocene cave bears
...ny. Twenty of the teeth ultimately provided useful mitochondrial DNA sequence (mitochondrial DNA is especially useful for tracking population changes). The findings indicated that while four sequence types (known as haplotypes) corresponded to bears 28,000 to 38,000 years old, a fifth DNA haplotype was found only ...Experimental Biology 2007: Today's Research, Tomorrow's Health, April 28-May 2
...rging infectious diseases; new insights concerning mitochondrial DNA and human disease pathology; the genetics and pathogenesis of autoimmunity; viruses and human cancer; developmental pathways in cancer progression; new developments in vascular biology; pharmacogenomics and targeted therapies; stem cells for the...New DNA study helps explain unique diversity among Melanesians
... the planet have significant differences in their mitochondrial DNA that can be linked to where they live, the siz...uinea and the University of Pennsylvania, examined mitochondrial DNA sequences from 32 diverse populations on four Melanesian islands, an island chain north and nort...New study rewrites evolutionary history of vespid wasps
...pairs from two genes (one ribosomal RNA, the other mitochondrial DNA) and included very few representative species, some of which were unsuitable for the analysis. The new study examined variations in fragments of four genes across 30 species of vespid wasps. Four independent statistical analyses tested the reli...How eating less might make you live longer
... overall calories burned), which suggests improved mitochondrial function. Their analysis of genes involved in mitochondria formation indicated that CR and CREX both increased the number of mitochondria in muscle. Both interventions also reduced the amount of DNA damagea marker of oxidative stressin the participan...$7.9M awarded to UCI stem cell scientists
... to investigate the importance of mitochondria and mitochondrial DNA in the preparation of human embryonic stem cel...etermine the nature of compatible and incompatible mitochondrial DNA and the consequences of their mixing. He also hopes to develop procedures to block adverse mixin...Mitochondrial genes move to the nucleus -- but it's not for the sex
BLOOMINGTON, Ind. -- Why mitochondrial genes ditch their cushy haploid environs to take u...inating species. So what, exactly, might be luring mitochondrial genes to the nucleus? "We're not quite sure why yet, but we've hypothesized that successful mitoc...Bacterial response to oxidation studied as toxin barometer
...ements and seeing correlations of GGKE response to mitochondrial damage in cell cultures. If we can create a library of cellular response, we might have either a generic or a specific predictor, said Brian Love, professor of materials science and engineering at Virginia Tech. We dont know yet because we havent t...Mouse FH knockout resembles human renal cell cancer
... the understanding of biochemical pathways linking mitochondrial dysfunction and tumorigenesis and will allow testing of potential therapies for renal neoplasms, says Dr. Pollard.......e and fuse other cellular structures -- was key to mitochondrial fragmentation. Article: " Mitotic Phosphorylation of Dynamin-Related GTPase Drp1 Participates in Mitochondrial Fission " by Naoko Taguchi, Naotada Ishihara, Akihiro Jofuku, Toshihiko Oka, and Katsuyoshi Mihara MEDIA CONTACT: Katsuyoshi Mihara, D...