Stanford researchers establish center for physics-based simulations of biological structures
...o human movement." Mathematical and computational models provide the framework for understanding complexity...de the constraints necessary to drive and validate models and simulations. The problems under investigation are all currently existing peer-reviewed projects:...Daphne Koller named MacArthur Fellow
...s approach is that it has the ability to represent models of the world with significant complexity. "So far, most models have been fairly self-contained -- but the world does not work that way," Koller said. These ...Dying cells encourage neighbors to grow
...ch a mechanism contributes to hyperplasia in mouse models and human malignancies," offers Dr. Steller. ...Protein energy profiles offer clues about amyloids
...ibuted computing project. "By designing simplified models that retain the essential physical and chemical features of protein dynamics, Clementi's team is making excellent progress in quantitative prediction -- work that's highly complimentary to the detailed simulations we're creating through Folding@Home....New genetic tools provide clues to the effects of exercise and diet on obesity, diabetes
...chemical adaptations complement existing molecular models for improved glucose tolerance with exercise intervention in pre-diabetic individuals, he noted. On the proteomics side, the researchers analyzed gene expression and protein profiles from muscle of lean and obese and morbidly obese individua...Touching research: How white blood cells navigate
...forces on blood cells; they're developing computer models that simulate how blood cells get buffeted about by other cells in the circulation; and they use the tiniest of tools to measure how cell-like beads stick to surfaces. "Many people with an expertise in fluid mechanics might go into the petroleum in...Laboratory test of evolutionary theory confirms importance of links between populations
...gives us a halfway ground between the mathematical models and natural populations. It allows us to test whether our assumptions are realistic, and that puts us in a better position to design experiments in natural populations," Thompson said. Forde has also done extensive research on natural populations, s...Mechanism discovered for muscle wasting seen in diabetes, AIDS and other diseases
... the effects of blocking NF-kB activation in mouse models of muscle wasting, including immobilization/denervation and cancer. The former is a model for the muscle wasting that occurs during disuse, such as when a limb is casted, or in spinal cord injuries. Inhibition of NF-kB in MISR mice was accompanied ...How to use math and a CT scanner to see how trees intercept light
...ight intercepted by the plant. "Our system and our models will allow us to predict which branching patterns are more efficient at capturing light," said Dutilleul. "This is of obvious importance when choosing which plants to grow in environments with short photoperiod." Dutilleul has developed links between...Gene-altered mouse is model for rare autoimmune syndrome
...aders. While other genetically altered mouse models had been produced that showed similar symptoms, th... studies, we suspected that if we developed animal models lacking the gene we would not only better understand its role in immune development, but see disease...Early life stress can inhibit development of brain-cell communication zones, UCI study finds
...s needed to see if this blocker can work in animal models or in humans. The Baram group is continuing its study to learn if CRH is involved in adult dendrite atrophy. In previous studies, several research groups have found that chronic stress causes dendrite atrophy in adults, but it is not known if CRH pla...International human genome sequencing consortium describes finished human genome sequence
... "The analysis found that some of the earlier gene models were erroneous due to defects in the unfinished, d...quences from other organisms, better computational models and other improved resources." The Nature paper also provides the scientific community with a pee...For inferring the biological tree of life, simple is better
... a statistical model, but the assumptions of those models are usually wrong," Thornton said. "Parsimony make...problem is that the assumptions of risk assessment models are routinely violated, and safe levels often turn out to be hazardous. In many cases, we could prev...New genomic method can identify disease-causing genes
...day and help researchers more fully leverage mouse models of human disease to identify genes contributing to...ch is widely used. Since analyses of mouse genetic models by traditional methods are very time-consuming and costly, this novel computational approach represe...Mouse study: 'Critical' Down syndrome region isn't
...t Pennsylvania State University, used mathematical models she developed to compare the length, angles and po...tenet of Down syndrome research by using the mouse models to study the involvement of neural crest cells, precursors to structures affected in Down syndrome, ...Pesticides may promote Parkinson's disease and exercise may offer protection
...f this illness has allowed investigators to create models of disease that are being used to examine potential causes of neuron disease and to test experimental therapeutics in animals. Some of the research will eventually lead to the development of more effective treatments of this human illness. The secon...New center to map DNA of key lab mice
...o these disorders, but few well-established animal models are available for understanding the interplay of g...ill build a web-based storehouse of mouse research models accessible to scientists throughout the world. "The data base will allow scientists to pin-point th...Farmers don't need a new superstar toxin to fight bugs
...vade the main crop. "We used mathematical models to test this concept, and we were very surprised by the findings. Although these results are exciting, we are well aware that a number of issues must be addressed before this approach can become practically applicable." The other research...Medical informatics project targets ovarian, breast cancers
...ns for the purpose of developing better predictive models for ovarian and breast cancer. Ovarian cancer, despite its relative rarity, is the fifth leading cause of cancer death in women. Breast cancer is the second leading cause of cancer death in women. October is Breast Cancer Awareness Month.......ns, Smith and colleagues conclude, epidemiological models can be developed to predict risk for local populat...ons. Their results make the case that mathematical models can help public health officials calculate risk of infectious diseases in heterogeneous environments...