U Iowa researchers prevent hereditary deafness in mice
...gh a dominant negative mechanism, and the mice had moderate hearing loss. Next, Maeda simultaneously introduced the mutant gene and a short piece of interfering RNA specifically designed to silence the gene. Standard hearing tests, similar to those used on newborn babies, confirmed that the treated mice were ...Certolizumab pegol demonstrates positive results in two Phase III Crohn's disease trials
... induction and maintenance of clinical response in moderate to severe active Crohn' TM s disease. The PRECiSE trials assessed the safety and efficacy of CIMZIATM compared to placebo over a 26 week period, in a total of 1330 patients with active Crohn' TM s disease. Data from PRECiSE 1 and 2 will be presented...Joslin-chaired study shows new compound may decrease vision loss in diabetes
...RBX) was well tolerated and may reduce the risk of moderate vision loss, especially in patients with diabetic ...32 mg/day) on progression of diabetic retinopathy, moderate visual loss and sustained moderate visual loss. The study was conducted at Joslin Diabetes Center, ...Study to determine if air pollution accelerates development of cardiovascular disease
... seeks to better understand the importance of more moderate longer-term elevations of air pollution on cardiovascular diseases," said Burke, principal investigator for the Forsyth County portion of the study. The national principal investigator for MESA Air is Joel Kaufman from the University of Washington in...Highlights of the 2005 July Journal of the American Dietetic Association
...n polyunsaturated fatty acids can safely engage in moderate exercise without decreasing the amount of the fatt...three days per week. The researchers conclude that moderate exercise "is not only safe during lactation, but also provides many other health benefits." Elderly...Gene variant linked to chronic kidney disease
...study sheds light on susceptibility for developing moderate chronic kidney disease while other studies are increasingly focusing on the consequences and complications of chronic kidney disease, which include an increased risk of developing a heart attack, stroke and bone fractures. Charles C. Hsu, PhD, lead a...Cell's power plants also sense low oxygen
...wed that they do not accumulate HIF in response to moderate hypoxia," said Simon. "Also, our highly sensitive probe for ROS showed that the cells do not produce these species, either. Further, we found that in these cells, we can supply the missing signal that triggers HIF accumulation by adding back ROS." On...DOE JGI sequences DNA from extinct cave bear
...where found -- relatively dry, high altitude, with moderate temperatures--or if frozen, perhaps longer. "We picked cave bear as an initial test case ancient DNA target because the samples we used in the study are roughly the same age as Neandertals," Rubin said. "Our real interest is in hominids which inclu...A few 30 second sprints as beneficial as hour long jog
...e a week could be as effective as an hour of daily moderate activity suggests new findings from researchers at McMaster University. "Short bouts of very intense exercise improved muscle health and performance comparable to several weeks of traditional endurance training," says Martin Gibala, an associate prof...Scientists use gene transfer technology and common virus to block neuropathic pain
...filaments or exposing the skin to small amounts of moderate heat. People with neuropathy perceive the filament's touch or heat as a painful sensation. Rats with neuropathy will lift their paw if the filament or heat produces pain. Rats without neuropathic pain don't even notice. By monitoring whether rats li...Non-dieters more successful at boosting health than dieters, study finds
...study, the non-dieters had almost quadrupled their moderate physical activity. The dieting group had a significant increase in physical activity right after the treatment period ended but had slipped back to their initial levels by the end of the study. The non-dieters demonstrated significant improvemen...New data demonstrate that Benicar and Benicar HCT significantly reduces systolic hypertension
...ustments are necessary with BENICAR in elderly, in moderate to marked renal impairment (creatinine clearance In clinical trials, the withdrawal rates due to adverse events (AEs) were similar with BENICAR and BENICAR HCT to placebo: BENICAR (2.4% vs 2.7%); BENICAR HCT (2.0% vs 2.0%). The incidence of AEs wi...NexMed announces positive Femprox study results at American Urological Association Annual Meeting
...dy. The side effects reported were mostly mild or moderate in intensity, reversible and short in duration. Dr. Joseph Mo, NexMed's C.E.O. commented, "NexMed has reached another major milestone in the Femprox development program. We have completed one of the first large scale take-home studies for a topical...Clincal trials indicate NEXIUM can reduce upper GI symptoms in patients using NSAIDS
...duce upper gastrointestinal (GI) symptoms such as moderate to severe pain, burning and discomfort in the upper abdomen associated with continuous, daily use of non-steroidal anti-inflammatory drugs (NSAIDs), including selective COX-2 inhibitors. In the trials, NEXIUM 20 mg and 40 mg significantly improved...Heart failure wall stress drops 38% with moderate thyroid hormone therapy
...n the heart cells, a new study demonstrates that a moderate dose of thyroid hormones (TH) over 30 days "normal...laboratory where the research was performed. "But moderate TH therapy selectively targeted myocyte cross-sectional shape and modified it in a positive way. Th...Use of insecticides linked to lasting neurological problems for farmers
...led to conclude that their symptoms are related to moderate lifetime exposure," said Dr. Kamel. "Most studies of this issue have sample sizes ranging from 50 to 100 participants, making it hard to understand the detailed relationship between exposure and health effects. The large size of this study gives it ...Natural glucose byproduct may prevent brain damage and cognitive impairment after diabetic coma
... to also examine the effect of pyruvate after more moderate hypoglycemia, as more commonly experienced by diabetic patients." At the same time, Swanson believes that research on pyruvate therapy is ready to advance to the clinical level. "Pyruvate is a natural metabolite, present in our blood. There's no reas...Moderate alcohol consumption enhances the formation of new nerve cells
...in normal social situations. The results show that moderate drinking enhances the formation of new cells in th...the increased production of new nerve cells during moderate alcohol consumption can be important for the development of alcohol addiction and other long-term ef...Other highlights in the April 20 JNCI
...ction, as shown in sexually inactive women. A more moderate association between HIV coinfection and HPV persistence was observed, and could explain, in part, why cervical cancer rates have not reached epidemic proportions in HIVpositive women. Contact: Abe Habenstreit, Media Relations, Albert Einstein College......Ds over extended periods of time and were light to moderate tobacco smokers had 65 percent less risk of develo...tion in oral cancer risk particularly in light to moderate active smokers suggest that NSAID use may provide anti-carcinogenetic effect while the smokers are ...