Tag: "modulates" at biology news

JCI table of contents September 1, 2005

...rotein called Ldlr. They found that AR expression modulates atherosclerosis development in the diabetic animals. Thus, inhibitors of AR or other proteins that mediate glucose toxicity may be useful for treating diabetic atherosclerosis. TITLE: Human aldose reductase expression accelerates diabetic atheroscl...

Silenced gene in worm shows role in regeneration

...rly in the specification of stem cell progeny that modulates their ability to differentiate into the proper cell type," Snchez Alvarado said. How this molecule is modulating stem cells is one of the next steps that he and Reddien are trying to solve. The answer could have far-reaching implications, beca...

Food additive inhibits longevity enzyme in yeast, increases cell toxicity, new study finds

...ellular functions besides aging, and an agent that modulates sirtuins, such as DHC, could not only affect aging but also other critical functions, such as metabolism, neurodegeneration and cancer." Sirtuin enzymes are histone deacetylases, which modify the structure of chromatins, complex substances made up of...

Face perception is modulated by sexual orientation

... visual processing during which sexual orientation modulates how we perceive individual faces. The findings are reported by Felicitas Kranz and Alumit Ishai of the University of Zurich. Of all the visual skills possessed by humans, face recognition is arguably the most developed. Past brain imaging studies ha...

Translational control by RINGO/Spy

...served, sequence-specific RNA-binding protein that modulates polyadenylation, and thereby mRNA translation. Dr. Richter and his graduate student, Kiran Padmanabhan, now show that CPEB phosphorylation (and subsequent activation) is regulated by RINGO/Spy in Xenopus oocytes. Further analysis revealed that RINGO/...

Scientists link another gene to degenerative blindness

... to the parts of the cell they need to go. It also modulates calcium levels, which is critical for proper vision. When calnexin goes awry, however, calcium levels build up and the proteins that depend on it malfunction, says senior author Nansi Jo Colley, a medical geneticist at the UW-Madison departments of...

Pitt researchers find 'switch' for brain's pleasure pathway

..."burst firing" is how the brain signals reward and modulates goal-directed behavior. But just how the stimulus you perceive causes neurons to switch into or out of this mode has been a mystery. Using anesthetized rats, Lodge and Grace found that one area in the brain stem, known as the laterodorsal tegmental ...

Parasitic worms used to fight bowel disease

... parasites mount an anti-inflammatory defense that modulates it," said Mansfield, a professor of large animal clinical sciences. "The greater the immune response, the greater the anti-inflammatory effect. "It's possible that the human immune system developed in a way that is dependent on parasitic worms to reg...

Novel connection found between biological clock and cancer

...o the clock and the cell cycle. The clock normally modulates expression of this gene that encodes an important cell cycle regulator, and that cell cycle regulator in turn affects not only the cell cycle but also the clock. Recent evidence in mammalian cells shows that other cell cycle regulators physically ...

Life and death in the hippocampus: what young neurons need to survive

...ir maturation," explains Gage. " The NMDA receptor modulates synapse formation and determines what pattern of input activity new neurons receive, which in turn determines survival or death." Combining mouse genetics and gene transfer techniques, Gage and a team headed by former postdoctoral fellow Ayumu Tash...

Copper circuits help brain function -- could tweaking the circuits make us smarter?

...ake the right connections. We've found that copper modulates very critical events within the central nervous system that influence how well we think." The research was led by neuroscience graduate students Michelle Schlief, Ph.D., and Tim West, Ph.D., in collaboration with Anne Marie Craig, Ph.D., and David M...

Chemical genomic screening identifies novel therapeutic strategies for cancer

...he researchers further demonstrated that rapamycin modulates a signaling molecule linked to cell death and suggested that combination therapy with rapamycin and GC may be useful for treatment of ALL. Results from these two studies demonstrate that the gene expression-based chemical genomic approach represent...

Spring in your step helps avert disastrous stumbles, scientists say

...ing speed: In the case of the guinea fowl, the leg modulates itself within 26 milliseconds as it falls into an unexpected void. The lower limbs' spring action helps the birds retain energy and momentum, stabilize their center of mass, and continue forward motion through the hole. Biewener says this work coul...

Plant-derived molecules, genetic manipulation point to future chemoprevention methods

...0268 and another potential drug, Afzoxifene, which modulates the estrogen receptor, synergize in the prevention and treatment of certain mammary tumors in mice," said Liby. "This study takes our work further, establishing a relationship between CDDO-ME triterpenoids, which are also effective anti-inflammation ...

Researchers find biological clock for smell in mice

...ope to learn more about how and how much the clock modulates their sense of smell, and which cells and genes are needed. The olfactory bulb biological clock study opens up many questions, a key one of which is: Why are there multiple clocks? "This idea of multiple biological clocks is new," Herzog said. "We...

JCI table of contents: Jan. 18, 2007

... disease. TITLE: Direct interaction with filamins modulates the stability and plasma membrane expression of CFTR AUTHOR CONTACT: Sharon L. Milgram University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Phone: (919) 966-9792; Fax: (919) 966-1856; E-mail: milg@med.unc.edu . View the P...

JCI table of contents: January 25, 2006

...in individuals who are obese. TITLE: Adiponectin modulates inflammatory reactions via calreticulin receptordependent clearance of early apoptotic bodies PRESS CONTACT: Gina DiGravio Media Relations Boston Medical Center, Boston, Massachusetts, USA. Phone: (617)-638-8491; E-mail: gina.digravio@bmc.org . ...

Decision-making -- Demonstration of a link between cognition and execution

... This experiment showed that cognitive information modulates the coding of motor information via neurons which belong to the two key structures in the basal ganglia: at entry and exit. This is the first time that a cellular interaction has been demonstrated between purely cognitive and purely motor informatio...

Experimental Biology 2007: Today's Research, Tomorrow's Health, April 28-May 2

...on the skin and lungs); the ways in which nicotine modulates adolescent brain plasticity, interacts with other drugs during sensitive developmental periods, and, when used along with alcohol by a woman during pregnancy, alters drug responsiveness in offspring; an examination of why children, adolescents and a...

Stability of mRNA/DNA and DNA/DNA duplexes modulates mRNA transcription

...s needed to understand how thermodynamic stability modulates mRNA level....

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