Tag: "monoclonal" at biology news
NIH gives $8M to University of Pittsburgh School of Medicine for myositis research
...oves symptoms of these diseases. Rituximab is a monoclonal
antibody used and approved since 1997 by the Food and Drug Administration (FDA) for the treatment of B-cell non-Hodgkins lymphoma. It was approved in February 2006 for adult rheumatoid arthritis patients with an inadequate response to anti-TNF (tumor...
Antibody retards growth and induces death in liver cancer cells
...cular Cancer Therapeutics. Using a newly available monoclonal
antibody, they demonstrated significant reductions...ted human and mouse liver cancer cell lines with a monoclonal
antibody targeted against PDGFR. It resulted in a significant decrease in tumor cell proliferation a...
American Chemical Society's Weekly PressPac -- June 27/July 3, 2007
...combined with the ability to link gold nanorods to monoclonal
antibodies that specifically target cancer cells, may mean a promising new approach to early detection of cancer, the report states. ARTICLE #5 High Sensitivity of In Vivo Detection of Gold Nanorods Using a Laser Optoacoustic Imaging System DOWNLO...
Modified mushrooms may yield human drugs
... producing therapeutic proteins, such as vaccines, monoclonal
antibodies, and hormones like insulin, or commercial enzymes, such as cellulase for biofuels. "Right now medical treatment exists for about 500 diseases and genetic disorders, but thanks to the human genome project, before long, new drugs will be av...
Michael R. Zalutsky receives SNM's 2007 Paul C. Aebersold Award
...ping improved methods for the radiohalogenation of monoclonal
antibodies and peptides; in developing protein radiohalogenation methods for labeling monoclonal
antibodies and peptides that are rapidly internalized into tumor cells; for advancing the field of c...
SNM recognizes R. Edward Coleman with 2007 Georg Charles de Hevesy Nuclear Pioneer Award
...cs and radiation dosimetry of radionuclide-labeled monoclonal
antibodies administered for therapeutic purposes. He also investigates radionuclide therapy of neuroendocrine tumors, the metabolic characterization of brain tumorsbefore and after therapyand development of new methods for characterizing neuroendocri...
Avian influenza survivors' antibodies effective at neutralising H5N1 strain
...fectious Diseases in Bethesda, US, have shown that monoclonal
antibodies generated from blood of human survivors...hnique that allows them to rapidly reproduce human monoclonal
antibodies starting from a small sample of blood. "We can't say for certain that a pandemic influe...
'Nondanger' signal lowers immune reactions
...sylvania. In their study, the researchers used a monoclonal
antibody, engineered to bind to CR3, to trigger a ...Behrens, M.D., the first author of the study. "The monoclonal
antibody we used is already in a form that can be used for further studies. It has anti-inflammatory...
Pierre Ronco and Rashad Barsoum awarded for oustanding contributions to nephrology
...of pathomechanisms of glomerular disease including monoclonal
gammophathies and particularly the role of alloimmunization in the pathogenesis of glomerulonephrtis and allograft rejection. Receiving the award, Ronco acknowledged the work of the French renal community as well as the support of leading figures wit...
Jefferson scientists identify protein key to breast cancer spread, potential new drug target
...ially against early cancers, he says. While the monoclonal
antibody drug Herceptin has been very successful in treating ErbB2-positive breast cancer, patients can relapse, Dr. Pestell notes, and other drug targets are needed. The newly found secreted factor may prove to be such a target. Wed like to find ...
Preventing and treating lung cancer -- ESMO explores collaboration to fight cancer on all fronts
...ic approaches for advanced cancer, including using monoclonal
antibodies (Cesare Gridelli, IT, Paris Kosmidis, GR, Robert Pirker, AT and Nick Thatcher, GB) A comprehensive report on novel approaches to mesothelioma, including new drugs like pemetrexed, vorinostat and bevacizumab (Paul Baas, NL). ...
Immune response to cancer stem cells may dictate cancer's course
...lts over 40 test positive for a condition known as monoclonal
gammopathy of undetermined significance, or MGUS. MGUS itself is relatively benign, but in a small number of cases it progresses into multiple myeloma, a cancer of blood plasma cells. Yet despite the fact that MGUS and myeloma cells are genetically q...
Targeting tumors the natural way
...r approach employs a cell-binding agent, such as a monoclonal
antibody, that is powerfully attracted to the target receptor and holds fast to any cell displaying it. Although this strategy has benefits, it's not natural, says Kiessling. Cell recognition in living systems instead involves binding agents that att...
Notorious cancer gene may work by destroying messenger
...th, or bind to, its target mRNA. Peng then used monoclonal
antibodies to isolate PMR1 and the enzyme while the two were bound together, capturing both. After separating the two, the investigators identified the enzyme as Src, which is a member of a large family of molecules called tyrosine kinases. These mol...
UC Davis researchers use heated nanoprobes to destroy breast cancer cells in mice
...g magnetizediron-oxide nanospheres to radiolabeled monoclonal
antibodies. The bioprobesare cloaked in polymers and sugars that render them nearly invisible to thebody's immune system. DeNardo and her colleagues infused trillions of the probes -- more than10,000 can fit on the end of a straight pin -- into the...
JDRF forms partnership with MacroGenics
...y are poised to attack. Teplizumab is a humanized monoclonal
antibody that binds to an epitope of the CD3-epsilon chain expressed on mature T cells. In a June 2005 publication in the journal Diabetes, Dr. Herold reported two-year follow-up data for 21 subjects who received a single course of hOKT3-gamma-1 (...
Antibody extends life of mice with breast cancer
BUFFALO, N.Y. -- A monoclonal
antibody developed by researchers at the University at Buffalo has been shown to extend significantly the survival of mice with human breast-cancer tumors and to inhibit the cancer's spread to the lungs in the animals by more than 50 percent. The ...
Report calls for improved monoclonal antibodies against solid tumors
A new report by leading experts in monoclonal
antibody research for oncology offers a conceptual...ggest manipulation of the physical properties of a monoclonal
antibody as a potentially effective way to improve antibody treatments for solid tumors. Monoclon...
Eculizumab is well-tolerated and shows significant improvement in PNH patients (Ph III)
...hire, Conn., December 9, 2006 Eculizumab, a novel monoclonal
antibody investigational drug developed by Alexion...ong-acting C5 complement inhibitor, is a humanized monoclonal
antibody drug designed to selectively block terminal complement activation, thereby preventing destr...
New hope for patients with chronic lymphocytic leukemia
...sponse to chemotherapy alone, or combined with the monoclonal
antibody rituximab, relapse is inevitable and treatment options at that point are limited. Lenalidomide is a novel immune modulating, non-chemotherapy, cancer drug that is chemically similar to thalidomide, but is more potent in the laboratory and...
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