Genetic polymorphisms, antidepressant use may be associated with altered tamoxifen activity
...trations of tamoxifen and its metabolites. After 4 months of tamoxifen therapy, women carrying one or two copies of a CYP2D6 variant allele had lower plasma concentrations of endoxifen (an active tamoxifen metabolite) than women with the homozygous wild-type genotype. Among women carrying two copies of the ...NSBRI news: Bone-quality assessment tool for space and Earth
...ly. Studies of cosmonauts and astronauts who spent months on space station Mir revealed that space travelers can lose, on average, one-to-two percent of bone mass each month, with the greatest loss in the lower extremities like the femur and hip. The culprit is microgravity, which causes bone loss in criti...FDA approves ABRAXANE(TM) for metastatic breast cancer
...therapy for metastatic disease or relapse within 6 months of adjuvant chemotherapy. Prior therapy should have included an anthracycline unless clinically contraindicated. The approval marks a new class of "protein-bound particle" drugs, now made possible by ABI's proprietary nanoparticle albumin-bound (n...Weill Cornell team develops fast-acting anthrax vaccine
...cines currently available, which can take weeks or months to gain full effect. "This research is important, because in the event of an attack, it may not be known whether another attack is coming -- or who might be affected. In that case, you want immunity to be built up in key populations as quickly as po...Reduced calorie and carbohydrate diet slows progression of Alzheimer's disease in mouse model
...brain. The presence of plaques was evaluated at 12 months of age, which is an age at which plaques are known to be well developed in this strain. The investigators found that anti-amyloidogenic activities were increased in mice fed the restricted diet. In other words, the calorie restricted diet activated ...Albatross study provides new information vital to their conservation
...ng devices (geo-locators) to the bird's leg for 18 months or more, scientists at BAS found that most birds travelled from their breeding site off the coast of South Georgia to areas of the southwest Indian Ocean. Over half then made amazing round-the-world journeys the fastest in just 46 days. "Knowing w...B-15A iceberg's close encounter monitored by Envisat
...Media Player, 3Mb). The animation then moves four months back in time to illustrate the break-up of the original, larger B-15A (the current B-15A having inherited its name), split asunder by storms and currents while run aground on Ross Island, as observed by repeated ASAR observations. The animation ends ...UBC prof's research challenges prevailing theory of how new species evolve
...ding diversity of life," says Irwin, who spent ten months between 1994 and 2002 studying greenish warblers in Asia. "Until now, no one has been able to show continuous gene flow between reproductively isolated species via geographically connected populations a process of evolution called 'speciation by dis...DNA molecules used to assemble nanoparticles
...synthesis process is long and difficult, requiring months for each new molecule added to the dendrimer in se... the traditional way," Baker said. At two to three months per synthesis, and a significant loss of yield for each step, that approach just wouldn't be practic...A gene's fist 'kiss' sets off that affair known as puberty
...xist at birth, go into hiding at about four to six months of age, then reemerge in full force some 10 to 12 years later? "Puberty is critical to human development. And while there is a fairly good understanding of how the endocrine system regulates the hormones involved, just how and when the brain activat...Rush physicians using gene therapy for heart patients with moderate to severe chest pains
...ill be examined for chest pain at one month, three months and six months. A total of 404 patients will be enrolled in the study at the 20 study sites across the country....Not-for-profit publishers call NIH public access rule a missed opportunity
... release these manuscripts to the public within 12 months or less after publication in the journal. The timing of the release would be determined by the authors, who "should ensure that their PMC submissions are consistent with any other agreements, including copyright assignments," according to the NIH st...NJIT hosts Spring Career Fair: Employers expected to increase hiring...
...ate of employment opportunity during the last nine months has been in computer engineering. Students graduating with that major have promising job outlooks." To register for the career fair, please go to www.njit.edu/CDS , or call (973) 596-3646. Reporters interested in attending this career fair, please...Sexual cooperation: Mating increases longevity in ant queens
.... Sexual offspring are only produced after several months or years of colony growth, during which a sterile worker force is built up in the population. The fact that mates bond so early reduces the conflict between mating partners because both sexes benefit from the queen experiencing a long reproductive ph...PCRM develops world's first cruelty-free insulin assay
...um in millions of medical tests every year. After months of painstaking detective work, PCRM research analyst Megha Even, M.S., working with BiosPacific, an Emoryville, California, lab, succeeded in culturing cells using an animal component-free, peptide- and protein-free, media supplement as a replacement...Falling ants glide back to trunk to avoid dangers of forest floor
...re in Panama, but it was at that moment in Peru 18 months ago that I realized why they do it: They're trying to get back to the tree, they're trying to not get lost in the understory of the forest," he said. Once they hit the forest floor, he added, they're unlikely to find a chemical trail back to the nest...Bird brains show how trial and error may contribute to learning
...stitute (HHMI) predoctoral fellow, is in the final months of her doctoral training in the laboratory of co-author Allison Doupe at the University of California, San Francisco's Keck Center for Integrative Neuroscience. A similar brain pathway in humans may explain how children learn to talk by listening to......takes to determine a single protein structure from months to days. For example, a robotic arm drops protein solution into thousands of tiny wells for crystallization trials, and an imaging system quickly scans the wells looking for signs of crystal formation--key to capturing protein structures. "At this l...A startling diary reveals the onset of autism
... of autistic behaviour in children as young as six months of age. The findings are published today in Neurocase . Mel Rutherford, assistant professor of psychology at McMaster University, says the diary provides a rare and unprecedented opportunity to observe the early development of autism. She says the ...Embryonic stem cells treated with growth factor reverse hemophilia in mice
... becoming hepatocytes. After 115 days, nearly four months after injection, mice still produced factor IX without immune suppression. This occurred even in mice that were a complete immunologic tissue mismatch to the PEPs. In addition, the incidence of teratomas was low." The researchers believe this study d...