UCLA scientists design masks to hide genetic mutations from cell
...hers next step will be to test their findings in a mouse model. AUTHORS: Dr. Richard Gatti, professor of pathology and human genetics, and postdoctoral fellow Liutao Du at the David Geffen School of Medicine at UCLA, are available for interviews. JOURNAL: The research appears in the March 19 onl...Scientists unlock mystery of embryonic stem cell signaling pathway
...w embryonic stem cells without the feeder layer of mouse fibroblast cells that is essential for maintaining..., growing human embryonic stem cells on a layer of mouse fibroblasts has never made much sense to the scientists forced to do just that. Stem cells that grow...JCI table of contents: March 15, 2007
...ule inhibitor Nutlin-3a has antitumor effects in a mouse xenograft model of PEL. In the study, which appea...cal Investigation, Hua Gu and colleagues show that mouse CD8+ T cells lacking a protein known as Cbl-b can respond in vitro without receiving a signal throug...One Wwox isn't enough (to protect against cancer)
...f Wwox in human osteosarcomas and are generating a mouse model that will allow them to study the ability of the gene to reverse tumor growth after it is restored in adult animals with cancer. "Wwox-mutant mice are useful in understanding the role of this gene in human cancer, and they provide models for...Researchers use poliovirus to destroy neuroblastoma tumors in mice
...oblastoma the researchers constructed a transgenic mouse model that allows growth of neuroblastoma cells an... therapy. By injecting the virus directly into the mouse tumors, the researchers demonstrated that it was possible to reach their target and still avoid inte...Researchers identify molecular basis of inflammatory bowel disease
...ng sophisticated genetic methods, they generated a mouse model that does not express NEMO, a protein needed... are very similar, the insights gained through the mouse model are steps towards a better understanding of the mechanisms causing human inflammatory bowel di...Keeping the body in sync -- the stability of cellular clocks
...hour rhythms in such a noisy environment? Using mouse fibroblast circadian bioluminescence recordings from the Schibler Lab at the University of Geneva, the researchers turned to dynamical systems theory and developed a mathematical model that identified the molecular parameters responsible for the stab...Protein overexpression at heart of heart failure
...nd single-channel behavior were also observed in a mouse model of heart failure with cardiac overexpression...nducible beta 2a subunit overexpression transgenic mouse which was crossbred with the channel pore overexpressing mouse when still nonfailing (Adaptive phase...Mechanisms involved with tumor relapse identified
...e and eradicate tumor cells. Using a transgenic mouse model of breast cancer, researchers found that interferon gamma, a cytokine or chemical messenger that is produced by cells of the immune system upon activation, plays a role in tumor relapse. In humans, interferon gamma is also produced by white blo...CSHL shows correcting RNA splicing may help treat spinal muscular atrophy
...y (SMA) patients, and is now ready to be tested in mouse models. "SMA patients who suffer from motor-neuro...ified by the Krainer team as viable for testing in mouse models the next step in the process of developing new human therapies. "Families and advocates a...Scientists find hormone activity explains adolescent mood swings
... study its role in puberty, the researchers used a mouse model that reliably predicts the human condition. In this rodent model, the alpha4-beta2-delta receptor normally has very low expression, but increases dramatically at the onset of puberty in the part of the brain that regulates emotion. Paradoxicall...Stem cells act through multiple mechanisms to benefit mice with neurodegenerative disease
...ors first chose toapproach, as proof-of-concept, a mouse model of a representative lethalneurodegenerative disease. Next, they used mouse neural stem cells(NSCs), a type of "adult" stem cell, to establish the parameters of whatmight or mi...'Guardian of the genome' protein found to underlie skin tanning
...idence came when the researchers exposed human and mouse keratinocytes to UV radiation: After six hours, levels of both POMC and p53 were far higher than normal, and the level of pigment-stimulating alpha-MSH was 30 times above normal. Further experiments clinched the case for p53's role in tanning. When...Location, location -- Cell sizes, lives influenced by host size
... reveals that whether a cell lives in an elephant, mouse or something in between can make a big difference ...pace of its life, Savage said. The life spans of a mouse and elephant can differ by more than 70 years, and it takes a mouse 20 days of gestation before deli...Scientists identify protein that may promote migraines
... in their nervous system in addition to the normal mouse version of the protein. These mice had double the amount of inflammation in response to CGRP than did normal mice. Nerve-induced inflammation is one of the effects associated with migraine headache. Russo explained that his study raises the possibi...JCI table of contents -- March 8, 2006
...dence of this was provided by the observation that mouse hematopoietic cells engineered to express CDX2 wer... transplanted into mice. Expression of CDX2 in the mouse hematopoietic cells induced altered expression of a number of genes that encode HOX family of protei...Researchers learn what sparks plant growth
...ustard family that is to plant biologists what the mouse is to mammalian geneticists. "How do organisms decide when to grow and when to stop growing? These questions are especially important in plants because they are rooted in the ground and must alter their shape and size in response to their local env...CDX2 -- A protein that promotes leukemia
...dence of this was provided by the observation that mouse hematopoietic cells engineered to express CDX2 wer... transplanted into mice. Expression of CDX2 in the mouse hematopoietic cells induced altered expression of a number of genes that encode HOX family of protei...Breast cancer treatment heats up
...containing bioprobes into the bloodstream of a lab mouse bearing a human cancer tumor. The magnetic iron nanoprobesmore than 10,000 of which can fit on the end of a straight pinare concealed in polymers and sugars, making them nearly invisible to the body's immune system. Antibodies (joined with a radioact...Penn researchers discover new molecular path to fight autoimmune diseases
...re now extending this research directly to several mouse models of autoimmune diseases....