Biodesign Institute leads innovative project to prevent cancer
...nt challenge. But he has been encouraged by recent mouse studies in his lab, which have identified peptides...breast cancer. Lake is advancing these preliminary mouse studies by identifying peptides from human tumors that are candidates for a cancer vaccine. We bel...'Virtual' mouse brains now available online
...ed startlingly crisp 3-D microscopic views of tiny mouse brains -- unveiled layer by layer -- by extending ... innovations in action. In one video two different mouse brains -- one from a normal animal and the other from a rodent missing a gene linked to mental abnor...Scientists follow familiar TRAIL to new cancer therapy
...cer cells in culture and TRAIL-resistant tumors in mouse models. Sorafenib was recently approved by the FDA for treatment of renal cancer and is currently undergoing investigation in over 30 clinical trials for use against a wide range of human cancers, including melanoma, prostate, ovarian, pancreatic, lu...A gene that protects from kidney disease
...y to save patients suffering from NPHP. With a new mouse model Mathias Treier and his group at EMBL have sh...stic disease symptoms. It is the first time that a mouse model reveals increased cell death as the mechanism underpinning kidney degeneration in NPHP. The ge...Tracing Parkinson's lethal mechanism
...he researchers studied the mechanism of PD using a mouse model of the disease, in which a mitochondria-affecting toxin called MPTP is used to produce Parkinsons-like brain pathology. In earlier studies, they had found that MPTP activates protein-snipping enzymes called calpains in mitochondria. They also f...Link between immune system and mammary gland could shed new light on breast cancer
...ody to make yet more milk producing cells. Using a mouse model, the scientists were able to conclusively demonstrate the role of the Type 2 cytokines. When the signalling molecules were not present, production of milk producing cells was vastly reduced. Dr Walid Khaled from the Universitys Department of ...Cloning the male genome may help infertile men
...lege, Cornell University, New York, USA, said that mouse experiments by his team, led by Professor Gianpier...or Takeuchi and his team injected a single healthy mouse sperm into a mouse egg from which the nucleus had been removed, and by doing so cloned the male geno...Researchers discover method for identifying how cancer evades the immune system
...They studied the expression of these genes in five mouse tumor models for breast cancer, leukemia, colon cancer, lung cancer and renal cell carcinoma. They then compared two of these immune signatures with corresponding human tumors, eight cases of human ductal carcinoma and 11 cases of colorectal cancer. ...JCI Table of Contents -- July 2, 2007
...s for the prognosis of SCCs. TITLE: An inducible mouse model for skin cancer reveals distinct roles for g...nsfer diabetes to these animals when the recipient mouse also had the native B16:Y insulin B:923 sequence in its islets. The data demonstrate the dependence ...Tick-related disease thrives on cholesterol, study suggests
... the researchers collected blood samples from each mouse and also harvested each animal's spleen and liver. They determined the extent of the infection based on the amount of bacteria found in each tissue. Since the spleen and liver both filter blood, and the liver makes and stores cholesterol, the researc...M. D. Anderson team identifies new oncogene for brain cancer
...ogy. Using a gene transfer delivery system in a mouse model, a team led by Zhang and Professor of Pathol... gene, or genes, of interest and injected into the mouse brain. The viral particles infect only glial cells, where the genes are expressed. This system all...New approaches to endometriosis treatment -- mouse experiments point the way
...genesis by enhancing blood vessel growth. Using a mouse model of endometriosis, they found that these cells incorporate into the endometriosis lesions and enhance their growth. We also found that these cells have a similar effect on intra-abdominal tumours, he said. We therefore believe that targeting ...New method for reading DNA sheds light on basis of cell identity
... or off. The scientists examined these proteins in mouse ES cells known for their unusual ability to form nearly any tissue as well as two other types of descendant cells that are more limited in the developmental paths they can choose. One of the most remarkable findings involves a way of using chroma...Researchers find gene that spurs development of the epididymis
..., Jessica Tomaszewski, was examining the testes of mouse embryos when she noticed something odd: In one spe...he mutant embryos. Tomaszewski looked at younger mouse embryos from the same parents, to see how early in their development the abnormality appeared. She f...Damon Runyon names new class of rising stars in cancer research
...ornia, San Francisco, California, is designing new mouse models to challenge long standing dogma about how ...ladelphia, Pennsylvania, is designing new cell and mouse model systems of leukemia and glioblastoma to investigate the relationship between cellular energy p...MIT researchers reverse symptoms in mice of leading inherited cause of mental retardation
...s that the neuronal abnormalities in the fragile X mouse are reversed after they appear," said Eric Klann, a professor at New York University's Center for Neural Science. "This is very exciting because it suggests that PAK inhibitors could be used for therapeutic purposes to reverse already established men...Omega-3 fatty acids protect eyes against retinopathy, study finds
...nd the growth of destructive abnormal vessels in a mouse model of oxygen-induced retinopathy. The retinopathy in the mouse shares many characteristics with retinopathy of prematurity (ROP) in humans. ROP is a disease of the...JCI table of contents: June 21, 2007
...i.org/article.php?id=30178 Cardiology New mouse model for the study of some forms of human hypertension The angiotensin II receptor, type 1 (AT1) helps control blood pressure; its loss reduces blood pressure, while its overexpression leads to an increase in blood pressure. In a study appearing o...Scripps research scientists show protein accelerates breast cancer progression in animal models
...t cancer progression. Using genetically modified mouse models, the study found that the inappropriate exp...ancers of a more aggressive subtype. In those same mouse models, highly malignant cells of scirrhous carcinoma-a hard, fibrous tumor-were found to express ve...A faster way to recover from chemotherapy and marrow transplant
...ions in mammalian models. When dmPGE2 was added to mouse embryonic stem cells in the lab, production of blood stem cells increased. In mice that underwent bone marrow transplant, treatment with dmPGE2 led to enhanced blood-stem-cell formation, and the stem cells remained present in the marrow more than six...