Existence of muscle-building stem cells points to regenerative therapies for muscular disease
...olecular profiles of satellite cells isolated from mouse muscle. They showed that the satellite cells consist of two classes defined by the activity or inactivity of a gene called Myf-5. Moreover, that genetic difference gave rise to an important distinction in the satellite cells behavior. Cells without...News tips from the Journal of Neuroscience
...nd fear share some common elements and pathways in mouse and humans. 4. The Limits of Neuronal Grafts in Parkinsonian Rats Nathalie Breysse, Thomas Carlsson, Christian Winkler, Anders Bjrklund, and Deniz Kirik Transplantation of embryonic dopaminergic (DA) neurons has provided at least the makings of ...Adult stem cells from human cord umbilical cord blood successfully engineered to make insulin
...in which complex signals produced by the embryonic mouse pancreas were used to direct adult stem cells to begin developing, or "differentiating," into islet-like cells. As they grew these adult stem cells in the laboratory, the researchers conducted other tests in which the cells to be engineered showed...New mouse model closely mimics human cancers
...stitute scientists has developed a more human-like mouse model of cancer they say will aid the search for c... than those of conventional genetically engineered mouse models of cancer. To characterize these mouse tumors, DePinho collaborated with Lynda Chin, MD, also...A first -- Hebrew University scientist observes brain cell development in 'real time'
...te of Life Sciences at the Hebrew University, used mouse models to study how neurons, or nerve cells, develop from an undifferentiated cellular sphere into a rich and complex cell. This has great significance for the future of brain research, said Dr. Mizrahi, since "the structural and functional complexit...JCI table of contents: May 24, 2007
...in mice have shown that resistin is present in the mouse hypothalamus and that it is capable of activating specific neurons. These and other studies have highlighted the importance of a brain-liver circuit in controlling glucose and insulin handling in the body. In a study appearing online on May 24 in a...A nurse makes the decision on who will live
... results were obtained using a genetically altered mouse system created to study this selection process, which is called MHC restriction. During MHC restriction, all potentially harmful thymocytes must be weeded out (a process called negative selection). The remaining normal subset of thymocytes is induc......ribe how they got around the problem by creating a mouse model of the human malaria infection. They took a closely related mouse parasite and genetically modified it to produce an antigen that the human immune system recognises. ...Tiny genes may increase cancer susceptibility, Jefferson scientists find
...well Park Cancer Institute in Buffalo compared the mouse chromosome locations of genes known to affect canc...ight different types of tumors to the locations of mouse miRNAs. Reporting in the journal Proceedings of the National Academy of Sciences, the team showed ...Jefferson scientists use gene therapy to reverse heart failure in animals
...rease in the heart cell's ability to contract. The mouse hearts worked better and had stronger beats. In subsequent work, he and co-workers used gene therapy to restore S100A1 levels and heart function to normal in failing animal hearts. These results have significant implications for the future thera...News tips from the Journal of Neuroscience
...this weeks Journal , Meikle et al. describe a new mouse model of TSC based on conditional deletion of Tsc1... apparent by postnatal day 5 and, unlike other TSC mouse models, the mice developed spontaneous seizures. Pathological features of TSC, such as enlarged, abe...UVa researcher studying disease that cripples newborns
...(ribonucleic acid), his team created a new kind of mouse model. It attached many added CTG repeats to the D...amaged hearts did not recover. We showed in our mouse model that when you make this poisonous RNA, the mice get various aspects of myotonic dystrophy, Dr....Study identifying alteration in gene associated with uterine cancer
...ory. Future studies include testing these drugs in mouse models of endometrial cancer before being tested in humans. "We are planning to investigate FGFR2 in tumors from a much larger group of patients to determine whether mutations in the gene lead to aggressive cancers and poor outcome. Given how fr...Mice, men make livers differently
...ising difference. In a study of gene regulation in mouse and human liver cells, they found that master regu...s of the same language. By exploring the human and mouse versions, we hope to find an underlying grammar," said Fraenkel. Every cell in the human (or mouse...UF researchers awaken vision cells in blind mice
...therapy injection into the subretinal space of the mouse eyes, scientists measured the electrical activity in the retinas, finding that 19 of the 21 treated eyes positively responded to therapy, and 17 of those 19 had electrical readings from their retinas on par with those taken in normal mice. When the...Repair of DNA by Brca2 gene prevents medulloblastoma
...bnormal cells. These findings showed that the mouse model closely copied the human characteristics of ...m demonstrated the role of Brca2 in the developing mouse nervous system using a laboratory technique called conditional gene inactivation. This process elimi...Antibody-based therapies effective at controlling malaria
...falciparum antigens in mice and humans. An in vivo mouse model has significant advantage over the use of new world primates, the only other model for human malaria, which are labor-intensive and difficult to reproduce. These novel human reagents cured mice of an otherwise lethal malaria infection, and pr...Natural immune-control system may aid treatment of autoimmune disease and tissue rejection
...uthors indicate. Although the research was done in mouse cells, it is likely to apply to humans because of strong similarities between mouse and human immune cells. "We found that when we block a key interaction between two types of immune...Herpes infection may be symbiotic, help beat back some bacteria
...ew research, Virgin's group worked with strains of mouse herpes virus closely related to human Epstein-Barr...s virus and cytomegalovirus. During studies of how mouse herpes viruses transition from acute to latent infections, Virgin made a discovery that piqued his i...First demonstration of new hair follicle generation in an animal model
...s study, researchers found that wound healing in a mouse model created an embryonic window of opportunity. Dormant embryonic molecular pathways were awakened, sending stem cells to the area of injury. Unexpectedly, the regenerated hair follicles originated from non-hair-follicle stem cells. Weve found th...