Tag: "mouse" at biology news
Cancer scientists create 'human' leukemia process to map how disease begins, progresses
... already exists or by studying leukemia created in mouse
cells. This study flipped it around to focus on asking which are the normal cells within which the disease arises and then how it evolves and progresses, all within the context of human cells. "So what we are building is a new approach and way of...
Scientists identify key to integrating transplanted nerve cells into injured tissue
...onstrated this special stem-cell talent in damaged mouse
retinas. In those studies cells injected into injured retinas quickly integrated into the existing retinal tissue. Intrigued by this phenomenon, Young and his team believed that if they could identify and harness the key molecules used by stem cell...
Minuscule molecules pack a powerful punch
...ur work builds upon the sequences of the human and mouse
genomes, the power of computer analysis and microa...stitute. This success illustrates the power of the mouse
to reveal function and indicates a wider role for microRNAs in animals with large genomes....
Prize winners announced at ISN's World Congress of Nephrology
...he efficacy of vasopressin receptor antagonists in mouse
models of PKD. His outstanding efforts serving on the Scientific Advisory Board of the Polycystic Kidney Research Foundation (PKRF) have also been instrumental to advancing the field. Upon receiving the prize Torres expressed his gratitude and sense ...
Young children with epilepsy seizures could benefit from animal model of disease
... In two studies, the authors report developing a mouse
model of infantile spasms that produces effects closely resembling human infantile spasms. The mouse
model also responded to current treatments, including adrenocorticotrophic hormone (ACTH), in a simi...
New understanding of schizophrenia could lead to new treatment approaches
... genes lead to psychiatric disorders. Working in a mouse
model, researchers led by Gabriel Corfas, PhD, Kristine Roy, PhD, and Joshua Murtie, PhD, in the Children's Hospital Boston Neurobiology Program now demonstrate, for the first time, that alterations in NRG1-erbB signaling induce pathologic changes in...
Deactivating protein may protect nerve fibers in MS
...called cyclophilin D can protect nerve fibers in a mouse
model of multiple sclerosis. Cyclophin D is a key regulator of molecular processes in the nerve cell's powerhouse, the mitochondrion, and can participate in nerve fiber death. Inactivating cyclophilin D strengthens the mitochondrion, helping to prote...
First demonstration of muscle restoration in an animal model of Duchenne muscular dystrophy
...e demonstrated restoration of muscle function in a mouse
model of Duchenne's muscular dystrophy (DMD). The ...aches to ribosomes in all cell types within the MD mouse
model, overriding the mutation in the dystrophin gene that tells it to halt production of the protei...
ACS News Service Weekly PressPac -- April 18, 2007
...dified SS1P resulted in complete regression of the mouse
tumors, the first time that such an effect had been observed, the researchers said. PEGylation of SS1P and other immunotoxins may hold promise for use in cancer patients, as well, they added. ARTICLE #1 FOR IMMEDIATE RELEASE "Releasable PEGylation ...
Study links faulty DNA repair to Huntington's disease onset
...o observed an increase in oxidative lesions in the mouse
DNA. To see if the oxidative lesions played a role in expansion of the extra DNA segment, the researchers next deleted OGG1, a key enzyme in oxidative lesion repair. Without OGG1, the bulk of the DNAs oxidative lesions remained untouched, and the i...
JCI table of contents -- April 19, 2007
...leagues from Columbia University, New York, used a mouse
model of EDMD to define the signaling proteins act...g molecules downstream of beta-ARs is suggested by mouse
studies conducted by researchers from the University of Medicine and Dentistry of New Jersey. Mice...
UCLA/Toronto researchers unlock key to memory storage in brain
... to store them." Silva and his colleagues used a mouse
model to evaluate their hypothesis. They implanted CREB into a virus, which they introduced into some of the cells in the animal's amygdala, a brain region critical to emotional memory. Next they tested the mouse's ability to recall a specific ca...
How genetic malfunction causes a form of retardation
...ls. And in experiments with both cell cultures and mouse
embryos, they found that the same kind of mutation in SHP-2 that can be found in NS patients disrupts the neuron-glial balance by further promoting the formation of neurons and inhibiting glial cell formation. The researchers also studied the effec...
New findings in smell and taste
...r-specific patterns of neural activity in isolated mouse
olfactory bulb neurons that may provide a mechanism for the slow changes in the perceived qualities of odors. GABA, A Neurotransmitter Found in Taste Buds - Glutamate decarboxylase (GAD), an enzyme that produces gamma-amino butyric acid...
OHSU lab finds meth receptor that could lead to therapy
...andy's team explored the effects of these drugs on mouse
TAAR1 and a human-rat TAAR1 hybrid and found all three receptors respond in similar ways. "The results of this study unequivocally demonstrate that meth and amphetamine are able to directly activate this receptor in the laboratory, making it likely...
Carnegie Mellon University scientists identify genes activated during learning and memory
...r CREB or zif268 and sometimes both in human and mouse
genomes. A huge proportion of these genes had neve...ng a gene that appears to be activated in both the mouse
and human strongly suggests that the gene is involved in memory and learning," said Schwartz. "Genes...
Carnegie Mellon University research shows how sensory-deprived brain compensates
PITTSBURGH -- Whiskers provide a mouse
with essential information to negotiate a burrow o...by Carnegie Mellon scientists show just how well a mouse
brain can compensate when limited to sensing the world through one whisker. Published April 4 in the...
News tips from the Journal of Neuroscience
...m Green et al. this week. The authors supplemented mouse
chow with docosahexaenoic acid (DHA), an omega n-3 polyunsaturated fatty acid found in fish, and which is a major component of neuronal cell membranes. 3xTg-AD mice that exhibit A and tau pathology showed decreases in soluble A as well as reductions ...
Enhancing chemotherapy's efficacy: New agent has synergistic effect with standard drugs
...ratory cell cultures of human Kaposi's sarcoma and mouse
models carrying human lung and colon cancer cells. "Together, these findings indicate that MCP compounds have potential to be effective in combination with other anticancer agents," the authors concluded. Vladimir Khazak, Ph.D., now director of biolo...
Macaque genome analysis will help find human disease genes
...umans have at least 26 copies. Comparison with the mouse
genome suggests that there was a spurt of duplication of this gene early in primate evolution, and comparison with the macaque shows another spurt of copying in both humans and chimpanzees, with the greatest duplication in humans and with evidence fo...
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