Tag: "muscle" at biology news
NIH gives $8M to University of Pittsburgh School of Medicine for myositis research
...hey are musculoskeletal disorders characterized by muscle
weakness thought to be autoimmune diseases. This m...or reasons unknown turns on itself and attacks the muscle
tissue and sometimes skin, joints and lungs, causing rash, arthritis and shortness of breath. The...
High blood pressure, low energy -- a recipe for heart failure
...h reveals that impaired energy production in heart muscle
may underlie heart failure in some hypertensive pa...e stress of a cardiac pressure overload asks heart muscle
to manufacture more high energy compounds, and without ERR alpha, they can't do it," explains Kelly,...
Abnormal fat metabolism underlies heart problems in diabetic patients
...ot only interferes with the energy supply of heart muscle
cells, it also increases the amount of damaging ox...found a dramatic depletion of cardiolipin in heart muscle
as early as five days after diabetes was induced in mice." "These results suggest that cardiolipin a...
Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
...rain exhibited impaired glucose tolerance, reduced muscle
glycogen synthesis, decreased skeletal muscle
ATP (energy) levels, and decreased activity of an energy-producing enzyme called cytochrome c oxidas...
Antioxidant overload may underlie a heritable human disease
...omyopathies, in which weakening skeletal and heart muscle
contain clumps of proteins. Although the genetic basis for the disease had been linked to mutations in one of two genes, the mechanism responsible remained mysterious. The researchers now show that mice with one of the mutant genes, B-crystallin, s...
JCI table of contents: Aug. 9, 2007
...in this region. It is characterized by loss of the muscle
cells of the heart (cardiomyocytes). Although this...mice) and is accompanied by increased death of the muscle
cells of the heart (cardiomyocytes) by a process known as apoptosis and decreased cardiomyocyte expr...
Testosterone replacement therapy: How safe for aging men?
...ments have been used by aging men to improve their muscle
mass, bone strength, libido and quality of life. In 2002, the number of elderly American men taking testosterone replacement therapy was nearly 819,000, and the number is growing. The increased use has occurred despite the fact that the cardiovascula...
Anthrax bacterium's deadly secrets probed
...nimal host. Some breakdown animal protein such as muscle
fibres, others are the toxins which eventually kill the host, but others belong to the group of proteins of unknown function unique to pathogenic bacteria. We dont know what these latter proteins do but we think they help the organism to evade the im...
UF, French scientists seek test to detect gene doping in athletes
...mselves with genetic material capable of enhancing muscle
mass or heightening endurance. If an athlete injects himself in the muscle
with DNA, would we be able to detect that" asked one of Frances leading gene therapy researchers, Ph...
How a pain in the neck could be bad for your blood pressure
...now like to know what other brain regions the neck muscle
termination site connects to. They believe that there are many malfunctions associated with whiplash injuries to the neck that could be better understood by unravelling these connections. They hope that this knowledge could be used to design more ef...
Under magnetic force, nanoparticles may deliver gene therapy
...c fields to direct the nanoparticles into arterial muscle
cells, where the DNA could have a therapeutic effe...dy team steered the particles into arterial smooth muscle
cells. Inside each cell, the DNA separated from the particle, entered the cell nucleus, and produced...
Stem cell therapy rescues motor neurons in ALS model
...agnosis. Patients gradually experience progressive muscle
weakness and paralysis as the motor neurons that control muscles are destroyed by the disease. The cause of ALS is unknown. In the new Wisconsin study, nascent brain cells known as neural progenitor cells derived from human fetal tissue were engine...
Cell damage caused by brushing may help keep gums healthy
...t only epithelial cells on the tongues surface but muscle
cells underneath as well. The mechanical forces mu...n transmitted through the intact epithelium to the muscle
cells, says Dr. McNeil, director of the MCG Cell Imaging Core Facility. It means our epithelium is t...
American Chemical Society's Weekly PressPac -- July 25, 2007
...ful use of a drug-like molecule to transform human muscle
cells into nerve cells. Their report, scheduled fo...y notes. The researchers exposed immature mouse muscle
cells (myoblasts) growing in laboratory cell cultures to neurodazine, a synthetic small molecule. Af...
Research teams uncover risk genes for multiple sclerosis
...tral nervous system whose symptoms range from mild muscle
weakness to partial or complete paralysis. It is widely considered an autoimmune disease that arises from a combination of genetic and environmental factors. This collusion of events leads the body to attack and destroy the insulation along nerve fib...
First new multiple sclerosis gene found in 30 years
...eads to the symptoms of the disease, which include muscle
weakness, cognitive impairment, difficulties with balance and coordination, and speech and vision problems. What triggers this autoimmune response is likely a result of a complex interplay between genetic and environmental factors, Gregory said. Th...
Risk genes for multiple sclerosis uncovered
...tral nervous system whose symptoms range from mild muscle
weakness to partial or complete paralysis, is widely considered an autoimmune disease, one that arises from a combination of genetic and environmental factors. This collusion of events leads the body to attack and destroy the insulation along nerve f...
Drug protects brain cells in Huntington's disease model, researchers find
...untries, but not the U.S., to treat uncontrollable muscle
movements in Huntingtons and other neurological conditions. Huntingtons is a fatal genetic condition that usually manifests around ages 30 to 45, according to the Huntingtons Disease Society of America. About one in 10,000 people in America have t...
Radiation therapy combined with microsurgery shows promise for curing injured spinal cord
...resulting restoration of control of the brain over muscle
function. In the current research, the scientists made a severe crush injury, similar to a human contusion/fracture injury, in spinal cord of adult rats just below the waist. In crush injuries, tissue decay is exacerbated by the secondary damage c...
Enzyme discovery sheds light on vitamin D
...with other diseases, including multiple sclerosis, muscle
weakness, and bone-related disorders, he notes....
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