JCI table of contents -- April 19, 2007
...s mediate heart function defects in Emery-Dreifuss muscular dystrophy Emery-Dreifuss muscular dystrophy (EDMD) is characterized mainly by defects in heart and muscle function and is caused by mu...The sturdier sex? -- Study by Pittsburgh scientists finds female stem cells work better
... in the lab while searching for a cure for Duchene muscular dystrophy (DMD). DMD is a genetic disease estimate...fter cell transplantation in the animals that have muscular dystrophy. Transplantation of female cells leads to a much more significant level of skeletal muscle...Deflecting damage: Flexible electronics aid brain injury research
...ising applications for the engineering of nervous, muscular and skeletal tissue. For instance, Morrison said, the electrodes could potentially be used to train heart tissue grown in the lab to contract appropriately when stimulated. The new membranes build upon work done by Lacour during her time at Princet...Switching genes to overdrive improves muscular dystrophy symptoms in mice
...e genes counteracts the damage caused by a form of muscular dystrophy. Reporting in the April 1 issue of Gen...enes activity in the muscles of mice with Duchenne muscular dystrophy, slowing the disease-associated muscle wasting. The authors caution that they have not yet...New therapeutic insight into duchenne muscular dystrophy
...nt of and possible therapeutic target for Duchenne muscular dystrophy. Duchenne muscular dystrophy (DMD) is the most common form of muscular dystrophy, affecting about 1 in 3000 males each ...JCI table of contents -- March 22, 2007
...FLAMMATION: Inflammatory pathway leads to Duchenne muscular dystrophy Duchenne muscular dystrophy (DMD) is characterized by progressive muscle wasting and usually results in death by the a...$7.9M awarded to UCI stem cell scientists
... Those projects had focuses ranging from cancer to muscular dystrophy. UCI is at the forefront of stem cell research. It is home to the Sue and Bill Gross Stem Cell Research Center, which promotes basic and clinical research training in the field of stem cell biology. More than 60 UCI scientists use stem ce...CSHL shows correcting RNA splicing may help treat spinal muscular atrophy
... corrected an mRNA splicing defect found in spinal muscular atrophy (SMA) patients, and is now ready to be tes...isantisense technology for the treatment of spinal muscular atrophy. Wehave high hopes for the success of the next phase of the work", said CynthiaJoyce, Execu...When your brain talks, your muscles don't always listen
..., the muscle fibers contract. In the generation of muscular force, the smallest controllable unit consists of ...s Human Performance Lab, Knight has been examining muscular force on a very small scale in the index finger, specifically, the first dorsal interosseous muscle....Drug blocks lethal motor-neuron disease in mice
Spinal muscular atrophy (SMA) is an inherited motor-neuron disease that, in its most severe form, leads to death before 2 years of age and for which there is no treatment. It is caused by mutations in the gene SMN1 that prevent SMN1 producing the protein SMN. A seco...JCI table of contents -- February 22, 2006
...ocks lethal motor-neuron disease in mice Spinal muscular atrophy (SMA) is an inherited motor-neuron disease...expression and survival in a mouse model of spinal muscular atrophy AUTHOR CONTACT: Charlotte J. Sumner National Institutes of Health, Bethesda, Maryland, USA...Treatment extends survival in mouse model of spinal muscular atrophy
...al and improve movement in a mouse model of spinal muscular atrophy (SMA), new research shows. The study, carried out at the NIHs National Institute of Neurological Disorders and Stroke (NINDS), suggests that similar drugs might one day be useful for treating human SMA. "This study shows that treatment can...UCI awarded $3.5 million for stem cell research
...day. Six UCI projects with focuses ranging from muscular dystrophy to mitochondria were selected by the In...ucture formed at DNA sequences linked to a form of muscular dystrophy. She plans to develop human embryonic stem cells associated with the disorder and compare ...Bats prey on nocturnally migrating songbirds
...ic signatures of whole insect bodies and passerine muscular tissues were tracked throughout the year, serving as a control. The results elegantly showed that the bats ate only insects in summer, included some songbirds' flesh in their diet during spring, and depended a great deal on passerines during autumn. ...JCI table of contents -- February 8, 2006
...ing protein have been identified, such as Duchenne muscular dystrophy. TITLE: Nonsense-mediated mRNA decay affects nonsense transcript levels and governs response of cystic fibrosis patients to gentamicin AUTHOR CONTACT: Batsheva Kerem The Hebrew University of Jerusalem, Jerusalem, Israel. Phone: +972-2-6...Power-boosting signal in muscle declines with age
... with a stimulatory chemical showed an increase in muscular AMPK activity not seen in old rats, they found. Similarly, the muscle of exercise-trained young rats showed more than a doubling in AMPK activity. In older rats, that AMPK hike with exercise was "severely blunted." The muscles of young rats fed the A...Brown cancer biologists identify major player in cell growth
... may shed light on everything from miscarriages to muscular dystrophy. The main application, however, is cancer. Since a key characteristic of cancer cells is unchecked growth, the research identifies potential targets for new treatments. "As a scientist and a physician, I am tremendously excited," said Ala......epsy, chronic pain, neurodegenerative diseases and muscular diseases, and ion channels are the target of many drugs. Understanding the basic biological phenomena behind the way proteins organize themselves and orchestrate biological processes may allow scientists to design better or more efficient drugs....'Marathon mice' elucidate little-known muscle type
...otential importance for the therapy of a number of muscular and neuromuscular diseases in humans," Spiegelman'...ity, including paraplegia, prolonged bed rest, and muscular dystrophies, involve a loss of oxidative fibers and their replacement with glycolytic fibers. This, ......g illnesses such as amyotrophic lateral sclerosis, muscular dystrophy, post-traumatic stress syndrome and schizophrenia is influenced by the number of receptors on nerve cells. The more receptors each cell has at its communication points, or synapses, the better that messages are carried through the brain. A...