U of MN researchers develop mouse model for muscle disease
...a very poorly understood muscle disease similar to muscular dystrophy that is characterized by generalized mus...in in muscle cells that if absent, causes Duchenne muscular dystrophy, a severe form of MD that effects primarily males and results in early death. Originally, ...Toxic molecule may cause most common type of muscular dystrophy
...everse myotonic dystrophy, the most common type of muscular dystrophy in adults. About 40,000 people in the United States have myotonic muscular dystrophy (MMD). The disease can cause a slow, progressive wasting of the muscles, irregular heartbe...FSU biologists uncover mechanisms that shape cells for better or worse
...findings in fruit fly eggs may help to clarify how muscular dystrophy and some cancers develop in humans. That's because many of the genes involved in the cell-to-cell communication that triggers the development of cell polarity in Drosophila oocytes (unfertilized fruit fly eggs) also are known players in t...Emory scientists develop new map of genetic variation in human genome
...son insertions have been identified in hemophilia, muscular dystrophy and cancer. "Were entering an exciting new era of predictive health where an individuals personal genetic code will provide guidance on healthcare decisions says Dr. Devine. "Our maps of insertions and deletions will be used together with...Ossur takes another giant step in prosthetic technology
...tic function solely by means of joint mobility and muscular activity. "The next level will happen when the prosthetic device can actually anticipate the intention of the user," says Janusson. In other words, you'll think about taking a step and your foot will act. This can only be achieved when the prosthesi...UF scientists test improved gene therapy method for hereditary heart conditions
...ccessfully reverse symptoms in mice with a form of muscular dystrophy that damages the heart. They also tested...ar for patients with Pompe disease, a rare form of muscular dystrophy that is usually fatal in the first year of life. "Nine years ago we knew we could get lo...UF scientists reverse muscle contractions in mouse model of muscular dystrophy
...mouse model of the most common form of adult-onset muscular dystrophy. The inherited disorder, known as myot... hope of people suffering from this common form of muscular dystrophy that a treatment could someday be forthcoming that will address the many serious component...Scientists identify protein with a crucial role in cell death
...hese mice deteriorated very rapidly − losing muscular strength after only 4 weeks, which greatly reduced their capacity for breathing − and, after 8 to 12 weeks, they died. Thus, a lack of PARL leads to weakening of (muscle) cells, a phenomenon that also occurs in the normal ageing process. This r...Reversing 'hibernating' heart muscle focus of UB researchers
... condition in which myocytes (cells in the heart's muscular tissue) shut down, but remain viable in areas that receive reduced blood flow over an extended period of time due to narrowed arteries. This creates areas of the heart that contract poorly. The new grant from the National Heart Lung and Blood Inst...Epilepsy drug eases symptoms of inherited disorder that weakens muscles
... of the drug valproate to treat seven adult spinal muscular atrophy (SMA) patients. Clinicians offered the drug to patients on the basis of research conducted elsewhere that showed the drug increased levels of a key protein in cell cultures. "The treatment has been fairly successful," says lead author Chris W...Neurons grown from embryonic stem cells restore function in paralyzed rats
...s, amyotrophic lateral sclerosis (ALS), and spinal muscular atrophy. The study was funded in part by the NIH's...e of therapy might eventually be useful for spinal muscular atrophy, ALS, and other motor neuron diseases. *Deshpande D, Kim YS, Martinez T, Carmen J, Dike S, S...New step toward treatment for Duchenne muscular dystrophy
...taken an important step toward a cure for Duchenne muscular dystrophy. After performing the first successful m...ne patients have shown promising results. Duchenne muscular dystrophy is a progressive weakening and degeneration of the muscles, caused by a mutation in a gene...Device that aids people with muscular dystrophy wins inaugural WPI Entrepreneurship Award
...motorized brace that enables people suffering from muscular dystrophy to perform simple tasks with their hands...ring at the hospital, and input from patients with muscular dystrophy, Scarsella, Toddes, and Daniel Abramovich '05 developed a prototype of a wearable, powered...A new kind of mutation could explain numerous phenotypic variations in various species
... the function of the derived protein is to inhibit muscular growth. The mutation discovered among sheep expose...result is that the absence of myostatin provokes a muscular hypertrophy among Texel sheep. A mechanism observed in other species as well However, Michel Georges...Jefferson scientists identify gene mutation potentially involved in breast cancer initiation
...atherosclerosis, diabetes, Alzheimer's disease and muscular dystrophy. The researchers, reporting in June 2006 in the American Journal of Pathology, say their results open up the possibility that Caveolin-1 mutations may be involved in the development of estrogen-positive human breast cancer, which accounts f...'Smart' genetic therapy helps the body to heal itself
...k on developing therapies for patients with spinal muscular atrophy (SMA). This is a relatively common inher...iscovered a promising genetic therapy for Duchenne muscular dystrophy (DMD). Using anti-sense molecules (small pieces of synthetic RNA that can bind to specif...Antioxidant tempol prevents pre-eclampsia, decreases fetal mortality in mice
... non-tempol treated mice retained abnormally thick muscular walls, Hoffmann said. Next step The researchers will next perform studies to ensure the tempol does not have serious side effects that might interfere with the development of the fetuses and pups, Hoffmann said. Then, understanding exactly how redu...First clinical trial of gene therapy for muscular dystrophy now under way
...apy human trial in the United States for a form of muscular dystrophy is under way. The clinical trial for Duchenne muscular dystrophy (DMD) tests the safety and effectiveness of a therapy that was developed over two decades ...X chromosomes key to sex differences in health
...the X chromosome." Such diseases include Duchenne muscular dystrophy, hemophilia and Hunter syndrome, which causes dwarfing, abnormal bones and mental retardation in males but usually does not affect females who carry the same mutated gene. This duplication of genes is generally advantageous to women, but is...Scientists discover that widely available drug also helps fight kidney disease
...eater than the number affected by cystic fibrosis, muscular dystrophy, hemophilia, Down's syndrome, and sickle cell anemia combined. The disease is characterized by the proliferation of cysts that eventually debilitate the kidney, causing kidney failure in half of all patients by the time they reach age 50. C...