Ironman study redefines fine-tuned: Balance training time with blood pressure variability
...nded human capacity "Based on our experience with muscular and tendon recovery of around two weeks, we expected hemodynamic and sympathetic recovery to take at least two weeks," the study leader, Falko Skrabal, said. "In any case, because of muscle recovery time, you couldn't start hard training again for a ...Convergent evolution of molecules in electric fish
...tions in sodium channel proteins can cause serious muscular disorders, epilepsy and heart problems in humans and other vertebrates. But fish have two copies of many of their genes, and Zakon found that the duplicate sodium channel gene could mutate and evolve without harming the fish. "The spare gene gave...JCI table of contents: March 1, 2006
...y "progeroid" symptoms such as premature aging and muscular weakness. Lamins are structural proteins that support the membrane envelope of the cell nucleus. In a study appearing in the March issue of the Journal of Clinical Investigation, researcher Loren G. Fong and colleagues at the University of California...Masterminding muscle development
...rated MAML1-deficient mice, which displayed severe muscular dystrophy. The researchers showed that the modulation of MAML1 expression levels in cell culture experiments directly impacts the ability of the muscle gene transcription factor, MEF2C, to induce myogenesis: Increased MAML1 expression leads to enhanc...Various forms of human muscular dystrophy result from mutations in genes encoding ...hereditary laminopathies, including Emery-Dreifuss muscular dystrophy (EDMD), are associated with mutations in the LMNA gene that codes for the nuclear filament...A new way of looking at molecular motors
...n development defects, neurodegenerative diseases, muscular dystrophy, skin pigmentation problems, and genetic hearing loss. Researchers led by Dominique Soldati, a Howard Hughes Medical Institute (HHMI) international research scholar at the University of Geneva in Switzerland, have developed a new system of...Resveratrol prolongs lifespan and delays onset of aging-related traits in a short-lived vertebrate
...ed the onset of aging-related decays in memory and muscular performance. Resveratrol appears to be the first molecule to consistently cause life extension across very different animal groups such as worms, insects, and fish, and it could become the starting molecule for the design drugs for the prevention of...Missing steps of jumping-gene replication discovered
... genetic diseases, such as hemophilia and Duchenne muscular dystrophy. Retrotransposons are one class of jumping genes, with the L1 family being the most abundant in the human genome. Retrotransposons move by having their DNA sequence transcribed or copied to RNA, and then instead of the genetic code being t...Scientists find genetic pathway that could lead to drugs for kidney disease
...number of individuals affected by cystic fibrosis, muscular dystrophy, hemophilia, Down's syndrome, and sickle cell anemia combined. The disease is characterized by the proliferation of cysts that eventually debilitate the kidney, causing kidney failure in half of all patients by the time they reach age 50. ...Wide range of topics covered by new research units
... of the meat, which depends on factors such as the muscular structure and various environmental factors, including stress. The Research Unit "Functional Genetic Principles of Water Binding Capacity in Pork (DRIP)" will identify the specific regions in the genome that influence this specific property in pork. ...U of MN researchers identify ataxia gene
...eral sclerosis (Lou Gehrig's disease) and Duchenne muscular dystrophy.The research will be published in the February print issue of Nature Genetics, and posted online Jan. 22, 2006. Ataxia is a hereditary disease that causes loss of coordination resulting in difficulty with everyday tasks such as walking, spe...Unified physics theory explains animals' running, flying and swimming
...eed of birds in flight. The force generated by the muscular "motors" of runners, swimmers and fliers also conforms with surprisingly little variation to a universal value dependent only on muscle mass, Marden said. Why this relationship should be so had remained mysterious, he said. In the absence of a unif...Gene therapy for muscular dystrophy fixes frail muscle cells in animal model, Stanford study finds
...nd hemophilia might one day be useful for treating muscular dystrophy, according to a new study by researchers... dystrophin into mice with a condition that mimics muscular dystrophy. The dystrophin gene is mutated and as a result produces a defective protein in the roughl...Blazing a new path for Emery-Dreifuss Muscular Dystrophy
...e "laminopathies" include other heritable forms of muscular dystrophy, lipodystrophy, neuropathy, bone disorders and accelerated aging (progeria) syndromes. But no one knew why defective A-type lamins, which are expressed in almost all differentiated cells in the body, specifically affected the heart. Muchi...Mouse study: New muscle-building agent beats all previous ones
...ass in mice than a related potential treatment for muscular dystrophy now in clinical trials. The new agent is...ple whose muscles are wasting due to diseases like muscular dystrophy or side effects from cancer treatment or AIDS. "This new inhibitor of myostatin, known as...NJIT engineers use new technology to help children with cerebral palsy
...eers will use to help these children improve their muscular control and movements. "Those of us without d...sible to make therapy more effective so that their muscular coordination may be improved for the long-term," said Foulds. Many children who use electric wheelc...Restricting diet may reverse early-stage Parkinson's disease
...is controlled. Symptoms such as tremor or shaking, muscular stiffness or rigidity, slowness of movement and difficulty with balance appear when about 80 percent of cells in the body that produce the neurochemical dopamine die or become impaired. Incidence increases with age, and the disease is uncommon in pe...Chronic stress accelerates atherosclerosis following angioplasty procedure
...cute narrowing of the vessel by contraction of its muscular wall. However, this study showed that it has even more profound effects when it its levels are elevated chronically. In stressed rats which underwent angioplasty, NPY stimulated growth of abnormal smooth muscle in the blood vessels and caused them ...Muscular dystrophy and cancer-associated muscle wasting share dystrophin dysfunction
... Cancer Cell, describes an unexpected link between muscular dystrophy and muscle wasting associated with cance...rane that is mutated in the muscle wasting disease muscular dystrophy. Progression of cancer is associated with reduction of dystrophin and abnormal regulation ......al muscle protein that is also lost in people with muscular dystrophy. The findings provide a better underst...DGC). Dystrophin and DGC are also lost in Duchenne muscular dystrophy. "The loss of dystrophin and damage to the DGC appear to be key players in the developmen...