Chemical 'band-aid' prevents heart failure in mice with muscular dystrophy
...ice with the genetic mutation that causes Duchenne muscular dystrophy, according to scientists at the Universi...cts cardiac muscle, too. Many people with Duchenne muscular dystrophy die in their 20s from heart failure caused by cardiomyopathy, a gradual weakening of the h...$7.3 million NIH grant establishes Wellstone Muscular Dystrophy Research Center at the UI
...tone was a vocal supporter of research on Duchenne muscular dystrophy. In 2001, he introduced the Muscular Dys...clinical research into Duchenne and other forms of muscular dystrophy. After Wellstone's death, these centers were named in his honor. The center at the UI is t...Study in Royal Society journal on holly as an indicator of climate change
...enetic inviabilities (such as colour blindness and muscular dystrophy in humans) only when partners are of particularly high genetic quality, i.e., when the risk of having inviable offspring is reduced. Contact: Dr M Olsson, School of Biological Sciences, University of Wollongong, NSW 2522, Australia Journa...Groundbreaking study shows adult stem cells have same ability to self-renew as embryonic
... discovered while searching for a cure for Duchene muscular dystrophy (DMD), a genetic disease that is estimat...n every 3,500 boys. DMD is the most common form of muscular dystrophy affecting children and patients often die in early adulthood because of heart damage. In a...Study strengthens link between Foxp2 gene and language development
...ponsible for the coordination of complex voluntary muscular movement, as well as the maintenance of posture and balance). "It has been hypothesized that speech is somehow a finer example of a motor pathway -- a more demanding, more subtle pathway, but still a motor pathway," says Dr. Buxbaum. "Our animal mo......that causes children to age unusually quickly; and muscular dystrophy. For a list of MBL researchers and the organisms they use, or for further information on summer research and education at the MBL, please contact Gina Hebert at 508-289-7725....Lance Armstrong through a physiological lens: hard training boosts muscle power 8%
...stic that improved most (was) an 8% improvement in muscular efficiency and thus power production when cycling ...en maximal oxygen uptake." Combining the increased muscular efficiency with a planned 7% reduction in body weight and fat leading up to each Tour de France race...Tetanus toxin found to have therapeutic properties
...as a therapy to treat disorders caused by abnormal muscular contractions such as strabismus, cerebral palsy, anal contractions and torticollis. Recently these toxins have been used even in cosmetics against wrinkles. For these therapeutic and cosmetic applications, the scientists are working with sublethal do...Difference in talking louder, talking over noise depends on verbal cues, internal targets
...d to be the most efficient, and required the least muscular effort from the speaker." Indeed, participants said the noise scenario was the "easiest" in terms of producing SPL. 'Noise' prompts higher SPL, but also effort for clarity by slowing down Most interesting of all the findings was that in the "noise...JCI table of contents June 1, 2005
... associated with a congenital heart disease due to muscular defects. In a study appearing online on May 12 in advance of the print publication of the June issue of the Journal of Clinical Investigation, William Pu and colleagues from Harvard University evaluate the function of Gata4 in the heart muscle. The ...Researchers feed tiny pills of RNA to planarians to identify genes essential for regeneration
... diseases, such as ataxia (inability to coordinate muscular movements), bradyopsia (slow vision), and cancer. Only eight of those genes have a corresponding knockout gene in mice. This means researchers may be able to use planarians to learn about human diseases that can't be studied in other animal models. A...Discoveries by UAB and Florida scientists may help transplanted organs survive longer
...rried out in rat models, also showed that a single muscular injection of the molecule, interleukin-10 (IL-10), carried in a gene delivery vector, or mechanism, could provide long-term therapeutic effects. Anupam Agarwal, M.D., director of the UAB Nephrology Research and Training Center and senior author of th...Scientists analyze chromosomes 2 and 4
...on's disease, polycystic kidney disease, a form of muscular dystrophy and a variety of other inherited disorders. Chromosome 2 is noteworthy for being the second largest human chromosome, trailing only chromosome 1 in size. It is also home to the gene with the longest known, protein-coding sequence a 280,000...Human chromosomes 2, 4 include gene deserts, signs of chimp chromosome merger
...on's disease, polycystic kidney disease, a form of muscular dystrophy, and Wolf-Hirschhorn syndrome, a condition that causes severe birth defects and mental retardation. Human chromosome 2, the second largest human chromosome, originated during the evolution of Homo sapiens by the merger of two chimpanzee ch...Paralytic shellfish toxins cause mutation that allows clams to accumulate 100 times more toxin
...nerve impulse and therefore is vital to neural and muscular activity. What they did not know was why some clams were more resistant than others. The collaborative team of scientists from Washington, Maine, and Nova Scotia determined that the toxins cause a small mutation that prevents them from binding to the...Solving sleep problems helps epileptic children
...and Stroke. UF scientists monitored the brain and muscular activity of 30 children with epilepsy between the ages of 7 and 14 during single overnight stays. None of the children had seizures, but some awoke hundreds of times because of breathing problems. In all, 24 of the children -- 80 percent -- breathed ...Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
... muscle may reverse the symptoms of a rare form of muscular dystrophy, according to new research in mice condu...ty Medical Center. Infants born with the inherited muscular disorder called Pompe disease usually die before they reach the age of two. The researchers also sai...Studies expand understanding of X chromosome
...a, varied forms of mental retardation and Duchenne muscular dystrophy. "From studying such genes, we can get remarkable insight into disease processes. But the importance of the sequence goes beyond individual genes. We have also gained a deep insight into the way evolution has shaped the chromosomes that det...Rush physicians using gene therapy for heart patients with moderate to severe chest pains
...ly. The DNA plasmid is then taken up by the middle muscular layer of the heart wall near the injection site. Inside the cell, the DNA encoded VEGF-2 expresses itself which in turn stimulates the growth of new blood vessels by promoting the proliferation of endothelial cells in the heart. New blood vessels are...Green tea extract boosts exercise endurance 8-24%, utilizing fat as energy source
...d by habitual GTE intake, such as up-regulation of muscular beta-oxidation, contributed to the improvement in ...olism in muscle." Indeed, lab results showed that muscular beta-oxidation was higher in GTE-fed mice (compared with non-exercise and exercise-control mice), "s...