Study identifies the most common genetic cause of Parkinson's disease
...rder of the nervous system that causes tremors and muscular rigidity, affects more than one million people in the United States and is the second most common neurodegenerative disorder second only to Alzheimer's disease in frequency. The Cincinnati Children's study focused on a group of 767 Parkinson's disea...Zebrafish may hold key to understanding human nerve cell development
... leukemia, colon cancer, congenital heart defects, muscular dystrophy and other birth defects....JCI table of contents, December 15 2004
...full/114/12/1774 . Gene therapy improves spinal muscular atrophy in mice Spinal muscular atrophy is one of the most common genetic diseases leading to death in childhood. Characterized by m...Scientists solve the mystery of how Botox attacks nerves and eliminates wrinkles
...ed neurotoxin that causes tetanus, another serious muscular disorder that affects hundreds of thousands of people worldwide every year. "Perhaps one could develop drugs that would treat botulism and tetanus by competing with specific binding sites on the surface of the neurotoxin,'' he said. ''The idea is tha...UCSD researchers derive lessons about human evolution from chicken genome
...ntal disorders like cleft palate and diseases like muscular dystrophy. The draft of the chicken genome published in Nature is far from complete, but the focus now shifts to other efforts to sequence and analyze genomes and compare them to the human genome. The sequencing of dog and chimpanzee are already in...First analysis of chicken genome offers many new insights
...ntal disorders like cleft palate and diseases like muscular dystrophy. Researchers completed and made available the genetic sequence of the red jungle fowl -- a wild ancestor of the domestic chicken whose scientific name is Gallus gallus -- in March 2004. The genome provides several firsts: it is the first b...Zebrafish study yields observation of muscle formation
... to developing new treatments for diseases such as muscular dystrophy and to treating muscle injuries. However...tastic model system for development in general and muscular dystrophy in particular," says Henry....JCI table of contents, December 1 2004
...store expression of the protein that is lacking in muscular dystrophy. Many studies have shown that stem cells...sarcoglycan an animal model of cardiomyopathy and muscular dystrophy to determine whether these stem cells would be recruited to skeletal and cardiac muscle t...Columbia researchers identify drug as therapeutic candidate for spinal muscular atrophy
...ction of a protein lacking in patients with spinal muscular atrophy (SMA), a fatal pediatric genetic disease. It is the scientists' hope that the discovery will lead to additional developments and even a treatment for SMA, a neurodegenerative disease that is the leading genetic killer of children younger ...Pain reliever may help treat life-threatening childhood disease
...go may point the way to a new treatment for spinal muscular atrophy, or SMA, a muscle-wasting and often life-threatening childhood disease. A new study suggests that the drug, called indoprofen, increases the production of a protein that is key to the survival of the nerve cells affected by the disease. Indop......ligaments also mean human lower legs that are less muscular and lighter, requiring less energy to move them during running. Larger surface areas in the hip, knee and ankle joints, for improved shock absorption during running by spreading out the forces. The arrangement of bones in the human foot cre...Muscle loss from space travel, prolonged inactivity linked to two genes
...rs conclude that atrophy associated with prolonged muscular inactivity requires the involvement of nfb1 and bcl3 . Their findings are reported in the latest issue of The Journal of Clinical Investigation. The work was supported by grants from the National Space Biomedical Research Institute and the Natio...JCI table of contents, November 15 2004
...resistant to atrophy. The results demonstrate that muscular inactivity triggers the activation of P50 and Bcl3, which in turn may activate genes necessary for the development of atrophy. TITLE: Disruption of either the Nfkb1 or Bcl3 gene inhibits skeletal muscle atrophy. AUTHOR CONTACT:Sus...Joslin and Stanford researchers find key clues to muscle regeneration
...help scientists better understand diseases such as muscular dystrophy. Skeletal muscle contains a complex arr... stem cells could be used therapeutically to treat muscular diseases. Dr. Wagers' work disputes these past results, showing that bone marrow stem cells do move ...Children's Hospital Boston geneticist awarded for research on muscular dystrophy
...ics at Children's Hospital Boston and a well-known muscular dystrophy scientist, has received the major annual... for nearly two decades of work on the genetics of muscular dystrophy, a family of hereditary muscle-destroying disorders marked by progressive muscle weakness ...Molecular mechanism sheds light on neurodegenerative diseases
...fferent ways, from memory lapses to uncontrollable muscular movements, but it is now believed that these diseases share many common molecular mechanisms. A team of Northwestern University scientists, led by Richard I. Morimoto, John Evans Professor of Biology, has made a key discovery toward understanding o......during periods of altered metabolic demand such as muscular exercise or insulin stimulation. Such a powerful effector has also attracted some negative reaction, but Pedersen notes that IL-6 overall seems to have a "positive metabolic role in health and in the treatment of disease." For instance high levels ...