Multicenter study nets new lung tumor-suppressor gene
...ked the development of lung cancer in animals with mutated LKB1 and compared it to the experience of animals ... They found that while Kras "cooperated" with the mutated tumor-suppressor genes to produce lung cancer, it cooperated even more strongly with mutated LKB1. ...Defects in critical gene lead to accelerated lung tumor growth
...d LKB1. Their research indicates that this gene is mutated in almost a quarter of all human lung cancers. In ...e with defects in other tumor suppressors commonly mutated in lung cancer. These mice develop cancers of not just one lung cancer subtype, but exhibit all thre...Discovery in plant virus may help prevent HIV and similar viruses
... hairlike structures) and delayed flowering on the mutated plants, he said. In addition, mutant plants in which both genes were blocked died in the embryonic stage just as would an organism with only one gene. Now that Chen knows that Arabidopsis has two genes involved in the transcription process, his res...St. Jude study solves mystery of mammalian ears
...uos team took advantage of a previously discovered mutated form of prestin that does not make the outer hair ... sound waves as normal prestin does. Instead, the mutated form of prestin makes the cell extend itself when it vibrates. The St. Jude researchers reasoned ...New target for HIV/AIDS drugs and vaccine discovered
...possibility is the design of a vaccine including a mutated Nef protein unable to assist the virus in the control of its host. The research findings also raise another intriguing possibility: Nef proteins may be able to boost or suppress DC and NK cell activity. If so, it may prove to be a valuable new ther...U-M researchers identify gene involved in breast cancer
...ous cells. FOXP3 was found to be either deleted or mutated in a substantial portion of the cancer sample: abo...they noticed that female mice with one copy of the mutated form of the gene were developing breast cancer. Moreover, the tumors expressed high levels of ErbB2,...Study identifies new gene therapy tools for inherited blindness
...f the paper. "You need to identify the gene that's mutated in patients and obtain a healthy copy of that gene; you need an agent to deliver the healthy gene to a patient's cells, which is usually a weakened virus; and then you also need additional DNA elements that turn on the healthy gene in the right cells...JCI table of contents: July 19, 2007
...bins et al. used transgenic mice bred to express a mutated form of SHP2 in heart muscle cells during gestatio...r following birth. Embryonic hearts containing the mutated SHP2 had altered cardiomyocyte cell cycling and structural defects, while expression of the mutant p...MIT IDs link between brain tumor proteins
... The team focused on a protein called EGFRvIII, a mutated form of the cell receptor for epidermal growth factor (EGF). The mutated receptor, which is found in approximately a quarter of GBM tumors, is continuously active and relent......and colleagues generated transgenic mice harboring mutated versions of Ago2 in their bone marrow. The resear...thropoiesis in Ago2-deficient mice by expressing a mutated version of Ago2 that lacks its endonuclease activity, thereby demonstrating that the role of Ago2 in...New gene mutation identified in common type of dementia
...Italian family had no cases with two copies of the mutated gene. We would have expected to see cases with two copies of the mutated gene, especially since this family shares much of the same genetic material, as there have been at l...First all-African produced genetically engineered maize is resistant to maize streak virus
...ity of Cape Town took the opposite approach. They mutated a viral gene that encodes a protein that the virus... infects one of these transgenic maize plants, the mutated protein, which is expressed at a high level, prevents the virus from replicating and killing the pla...Researchers identify genetic mutation that may alter tumor cell proliferation
...in cancer has been that of an intermediary between mutated upstream regulatory proteins and downstream surviv...t regulate this network have also been shown to be mutated in a variety of cancers including lung, breast ovary, prostate, colorectal and brain cancers. This m...Alzheimer's prevention role discovered for prions
...ctive role of normal prion proteins is provided by mutated versions that are linked to genetic forms of prion disease because beta-amyloid fragments are able to form when the normal prion protein is corrupted by genetic mutation. Professor Hooper concludes: Until now, the normal function of prion proteins...JCI Table of Contents -- July 2, 2007
... the native B16:Y insulin B:923 peptide, but not a mutated B16:A insulin B:923 peptide (alanine at position 16 of insulin B chain), rendered CD4+ T cells able to rapidly transfer diabetes to these animals when the recipient mouse also had the native B16:Y insulin B:923 sequence in its islets. The data demons...Doing nature one better: Expanding the genetic code in living mammalian cells
...is particular job is done. From a large pool of mutated aminoacyl-tRNA synthetases the enzyme that loads ...tRNAs. While it is easy to screen large numbers of mutated aminoacyl-tRNA synthetases in bacteria and yeast, it cant be done in mammalian cells in the same way...Critical protein prevents DNA damage from persisting through generations
...on going," says Michel. Since the ATM protein is mutated in a number of lymphomas -- cancers of the lymph and immune system -- the new finding suggests to researchers that the lymphocytes could have been living with DNA damage for a long time, and that this damage likely plays a role in later chromosomal t...Loss of cell's 'antenna' linked to cancer's development
...t year showed that important gene, PKHD1, commonly mutated in PKD has also been found as a target of mutation in colorectal cancer. ...Scientists discover role of enzyme in DNA repair
...the role of an enzyme called ataxia telangiectasia mutated protein (ATM) in the bodys ability to repair damaged DNA. NIAMS and NCI are part of the National Institutes of Health (NIH). When DNA within a cell is damaged, the cells protective mechanism must do one of two things: repair the defect or commit su...Damon Runyon names new class of rising stars in cancer research
...y regulator of cell-to-cell communication commonly mutated in colon, liver, skin, and ovarian cancers called ...ng standing dogma about how p53, the most commonly mutated gene in human cancer, contributes to tumor formation and aging processes. Lszl Krti, PhD, with his s...