Tag: "mutation" at biology news

New antibody for EGFR causes lung cancer regression

...ess the same mutant EGFR, for example, some have a mutation that affects the intracellular part of EGFR and some have a mutation that affects the extracellular part of EGFR (known as the EGFRvIII mutant). The potential of therape...

JCI table of contents: January 25, 2006

...ess the same mutant EGFR, for example, some have a mutation that affects the intracellular part of EGFR and some have a mutation that affects the extracellular part of EGFR (known as the EGFRvIII mutant). The potential of therape...

Turning a cellular sentinel into a cancer killer

...ve any anti-tumor effect." For one thing, the high mutation rate in cancers might enable a cancer to switch the p53 pathway back off, or to circumvent the pathway in some other fashion. For those reasons, researchers were not sure whether the pathway would be a useful therapeutic target. To reactivate p53, Lo...

Reactivated gene shrinks tumors

...programmed cell death. When p53 is turned off by mutation or deletion, cells are much more likely to become cancerous, because they will divide uncontrollably even when DNA is damaged. In this study, the researchers used engineered mice that had the gene for p53 turned off. But, they also included a genet...

The new form of trypanosomiasis discovered in India stems from a deficiency in apolipoproteinL-1

...he absence of apolipoprotein results from a double mutation affecting its synthesis (4). In the absence of APOL-1, no other component of the human serum seems capable of forming pores in the parasite membrane and killing the trypanosome.Furthermore, a serological screening, conducted in 2005 by the Indian aut...

JCI table of contents: Jan. 18, 2007

...ndividual had 2 mutations in her GNRHR genes and 1 mutation in her FGFR1 gene, whereas the less severely affec...dentified, and although the overall effect of each mutation is to decrease CFTR expression at the cell surface, it is not known for every one of these mutations...

Scientists reveal secrets of Homer's Cyclops to help people with Holoprosencephaly

...ious disorder. The authors describe how a known mutation of the TG interacting factor (TGIF) gene, called T...mation. In particular, researchers found that this mutation not only does not produce the protein necessary for healthy fetal development, but the mutant protei...

Gene that makes people 'early to bed and early to rise' demystified

... mirror those in people with FASPS. In contrast, a mutation that mimicked an increase in phosphorylation at amino acid 662 increased the transcription of PER2 and pushed the animals' sleep pattern later. Their studies in mice revealed that the amino acid change associated with FASPS, which alters the charge ...

Novel regulation of the common tumor suppressor PTEN

...usive. Looking at a family with an inherited PTEN mutation that caused them to have the cancer-susceptibility... The Pandolfi and Jiang labs showed that the PTEN mutation in these patients prevented the addition of ubiquitin by NEDD4-1, providing a molecular mechanism fo...

JCI table of contents -- January 11, 2006

...hey are to prevent self-destruction In humans, mutation of the gene encoding a protein known as WASp leads...-deficient patient in whom a spontaneous revertant mutation occurred had substantial numbers of WASp+ Treg. These cells were able to ameliorate this individual'...

Regulatory T cells require WASp if they are to prevent self-destruction

In humans, mutation of the gene encoding a protein known as WASp leads...-deficient patient in whom a spontaneous revertant mutation occurred had substantial numbers of WASp+ Treg. These cells were able to ameliorate this individual'...

Genetic variation may reduce Alzheimer's risk

...Hill says. To determine the impact of the genetic mutation on Alzheimer's risk, studies need to be done on more Alzheimer's patients and their families, including taking blood levels of fetal hemoglobin, says Dr. Rodney T. Perry, UAB molecular geneticist and a study corresponding author. "More studies are ne...

Biophysical Society announces winners of 2007 Student Travel Awards

...vart Brass, Tel-Aviv University, Ramat-Aviv, Point mutation in the HCN4 Cardiac Ion Channel Pore is associated with Familial Sinus Bradycardia. Esther Caballero-Manrique, University of Oregon, Langevin Equation Approach to Bridge Different Timescales of Relaxation in Protein Dynamics. Hanning Chen, Un...

MGH Cancer Center researchers find new gene associated with Wilms tumor

...l (MGH) Cancer Center have discovered a novel gene mutation associated with Wilms tumor, the most common pedia...s have only one X chromosome, so for them a single mutation can silence the gene and cause a tumor," Haber explains. "Females have two X chromosomes, but one i...

Other highlights in the January 3 JNCI

...ne son. The study raises the possibility that some mutation or variant on the Y chromosome may be involved in prostate cancer. Although several studies have identified risk factors for prostate cancer and found some gene mutations that are associated with the disease, none of these can account for large num...

JCI table of contents: January 2, 2007

EDITOR'S PICK Genetic mutation alters response to heart failure drugs The gro...ectly was not determined. Similarly, humans with a mutation in the gene encoding ARH (who suffer from autosomal recessive hypercholesterolemia) are able to clea...

Bisexual fruit flies show new role for neurochemical

...essages at synapses," Featherstone said. The gene mutation also made the flies bisexual, leading him to name the gene "genderblind." "The mutants are completely bisexual, but fertile. It's the first gene that really specifically affects homosexual behavior without affecting heterosexual behavior," he said. ...

Profiling of cancer genes may lead to better and earlier detection

...ften lost in tumor cells. This can occur through a mutation in the gene's DNA sequence or through deletion of the gene. Loss of tumor suppression function also can occur in a process called methylation, where a chemical called a methyl group is attached to a DNA region near the gene and prevents it from being...

Genomic variation easier to identify with UCSD/Brown software

...rat and rabbit genomes, it is more likely that the mutation is, indeed, shared. "What we've created is a more accurate tool for detecting microinversions," said Benjamin Raphael, an assistant professor of computer science at Brown and a member of the University's Center for Computational Molecular Biology. ...

JCI table of contents: Dec. 21, 2006

...thcare System show that expression of the p62P392L mutation causes abnormal development of human bone cells in vitro and mouse bone cells in vivo but does not cause a Padget-like disease in mice. Specifically, expression of p62P392L in the precursors of human bone cells known as osteoclasts (the cells that de...

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(Date:11/3/2014)... Researchers from Australia report that low birth weight and ... (OA)-related hip replacements in adulthood. Findings published in the ... & Research , indicate that low birth weight and ... arthroplasty due to OA as adults. , According ... of 25 are diagnosed with clinical OA. Symptoms of ...
(Date:11/2/2014)... November 2014)—In support of a bold quest to rid ... Gates Foundation today announced an award of US$156 million ... (MVI) in building new vaccines that will interrupt the ... "accelerating to zero" agenda. Such vaccines would ensure that ... called an "immunological bed net." , This approach ...
(Date:11/2/2014)... Nate Silver and Richard Feynman walk into a bar and ... may sound like the setup to some late-night nerd sketch, ... increasingly cumbersome problem in modern biology, namely, finding meaning in ... instance, the data comprisesreams of cancer mutations that genome-wide studies ... new and efficient ways to parse the signal from the ...
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